Endoglin is not a major susceptibility gene for intracranial aneurysm among Japanese

Stroke

Volumn 34, Issue 7, 2003, Pages 1640-1644

  Onda, Hideaki ^a   Kasuya, Hidetoshi ^a   Yoneyama, Taku ^a   Hori, Tomokatsu ^a   Nakajima, Toshiaki ^b   Inoue, Ituro ^b  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Association; Genes; Intracranial aneurysm; Linkage (genetics)

Indexed keywords

ENDOGLIN;

ADULT; AGED; ALLELE; ARTICLE; CHROMOSOME 9; CONTROLLED STUDY; EVALUATION; EVIDENCE BASED MEDICINE; FAMILY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; INTRACRANIAL ANEURYSM; JAPAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SAMPLE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; UNINDEXED SEQUENCE;

ANTIGENS, CD; CHROMOSOMES, HUMAN, PAIR 9; EXONS; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTRACRANIAL ANEURYSM; INTRONS; JAPAN; LINKAGE (GENETICS); MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CELL SURFACE; SAMPLE SIZE; SENSITIVITY AND SPECIFICITY; STATISTICS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0038150202     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000075770.70554.99     Document Type: Article

References (19)

1. Kiyohara Y, Ueda K, Hasuo Y, Wada J, Kawano H, Kato I, Sinkawa A, Ohmura T, Iwamoto H, Omae T, Fujishima M. Incidence and prognosis of subarachnoid hemorrhage in a Japanese rural community. Stroke. 1989;20:1150-1155.
2. Longstreth WT Jr, Nelson LM, Koepsell TD, van Belle G. Clinical course of spontaneous subarachnoid hemorrhage: a population-based study in King County, Washington. Neurology. 1993;43:712-718.
3. Inagawa T, Tokuda Y, Ohbayashi N, Takaya M, Moritake K. Study of aneurysmal subarachnoid hemorrhage in Izumo City, Japan. Stroke. 1995;26:761-766.
4. Schievink WI, Wijdicks EF, Parisi JE, Piepgras DG, Whisnant JP. Sudden death from aneurysmal subarachnoid hemorrhage. Neurology. 1995;45:871-874.
5. Onda H, Kasuya H, Yoneyama T, Takakura K, Hori T, Takeda J, Nakajima T, Inoue I. Genomewide-linkage and haplotype-association studies map intracranial aneurysm to chromosome 7q11. Am J Hum Genet. 2001;69:804-819.
6. Takenaka K, Sakai H, Yamakawa H, Yoshimura S, Kumagai M, Yamakawa H, Nakashima S, Nozawa Y, Sakai N. Polymorphism of the endoglin gene in patients with intracranial saccular aneurysms. J Neurosurg. 1999;90:935-938.
7. Krex D, Ziegler A, Schackert HK, Schackert G. Lack of association between endoglin intron 7 insertion polymorphism and intracranial aneurysms in a white population: evidence of racial/ethnic differences. Stroke. 2001;32:2689-2694.
8. Kasuya H, Onda H, Takeshita M, Hori T, Takakura K. Clinical features of intracranial aneurysms in siblings. Neurosurgery. 2000;46:1301-1305.
9. Ikari K, Onda H, Furushima K, Maeda S, Harata S, Takeda J. Establishment of an optimized set of 406 microsatellite markers covering the whole genome for the Japanese population. J Hum Genet. 2001;46:207-210.
10. Brownstein MJ, Carpten JD, Smith JR. Modulation of non-templated nucleotide addition by Taq DNA polymerase: primer modifications that facilitate genotyping. Biotechniques. 1996;20:1004-1010.
11. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet. 1996;58:1347-1363.
12. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates, Inc; 1988.
13. Gougos A, Letarte M. Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. J Biol Chem. 1990;265:8361-8364.
14. Cheifetz S, Bellon T, Cales C, Vera S, Bernabeu C, Massague J, Letarte M. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem. 1992;267:19027-19030.
15. Li DY, Sorensen LK, Brooke BS, Urness LD, Davis EC, Taylor DG, Boak BB, Wendel DP. Defective angiogenesis in mice lacking endoglin. Science. 1999;284:1534-1537.
16. McAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE, Helmbold EA, Markel DS, McKinnon WC, Murrell J, et al. Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary hemorrhagic telangiectasia type 1. Nat Genet. 1994;8:345-351.
17. Shovlin CL, Hughes JM, Scott J, Seidman CE, Seidman JG. Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia. Am J Hum Genet. 1997;61:68-79.
18. Pece N, Vera S, Cymerman U, White RI Jr, Wrana JL, Letarte M. Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative. J Clin Invest. 1997;100:2568-2579.
19. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science. 1996;273:1516-1517.