메뉴 건너뛰기




Volumn 110, Issue 7, 2003, Pages 803-812

GAD67: The link between the GABA-deficit hypothesis and the dopaminergic- and glutamatergic theories of psychosis

Author keywords

AMPA; GABA; Glutamate decarboxylase; NMDA

Indexed keywords

4 AMINOBUTYRIC ACID; AMPA RECEPTOR; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; GLUTAMATE DECARBOXYLASE; GLUTAMIC ACID; ISOENZYME; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 0038127153     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-003-0826-8     Document Type: Review
Times cited : (53)

References (53)
  • 1
    • 0028948389 scopus 로고
    • Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics
    • Akbarian S, Kim J, Potkin S, Hagman J, Tafazzoli A, Bunney BJ, Jones EG (1995) Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry 52: 258-266
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 258-266
    • Akbarian, S.1    Kim, J.2    Potkin, S.3    Hagman, J.4    Tafazzoli, A.5    Bunney, B.J.6    Jones, E.G.7
  • 3
    • 0033930105 scopus 로고    scopus 로고
    • Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients
    • Anand A, Verhoeff P, Seneca N, Zoghbi S, Seibyl J, Charney D, Innes RB (2000) Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients. Am J Psychiatry 157: 1108-1114
    • (2000) Am J Psychiatry , vol.157 , pp. 1108-1114
    • Anand, A.1    Verhoeff, P.2    Seneca, N.3    Zoghbi, S.4    Seibyl, J.5    Charney, D.6    Innes, R.B.7
  • 4
    • 0030600546 scopus 로고    scopus 로고
    • Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures
    • Asada H, Kawamura Y, Maruyama K, Kume H, Ding R, Ji F, Kanbara N, Kuzume H, Sanbo M, Yagi T, Obata K (1996) Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures. Biochem Biophys Res Commun 229: 891-895
    • (1996) Biochem Biophys Res Commun , vol.229 , pp. 891-895
    • Asada, H.1    Kawamura, Y.2    Maruyama, K.3    Kume, H.4    Ding, R.5    Ji, F.6    Kanbara, N.7    Kuzume, H.8    Sanbo, M.9    Yagi, T.10    Obata, K.11
  • 6
    • 0036460091 scopus 로고    scopus 로고
    • Effects of intralaminar thalamic nuclei lesion on glutamic acid decarboxylase (GAD65 and GAD67) and cytochrome oxidase subunit I mRNA expression in the basal ganglia of the rat
    • Bacci J, Kerkerian-Le Goff L, Salin P (2002) Effects of intralaminar thalamic nuclei lesion on glutamic acid decarboxylase (GAD65 and GAD67) and cytochrome oxidase subunit I mRNA expression in the basal ganglia of the rat. Eur J Neurosci 15: 1918-1928
    • (2002) Eur J Neurosci , vol.15 , pp. 1918-1928
    • Bacci, J.1    Kerkerian-Le Goff, L.2    Salin, P.3
  • 8
    • 0029853927 scopus 로고    scopus 로고
    • Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging
    • Bertolino A, Nawroz S, Mattay V, Barnett A, Duyn J, Moonen C, Frank JA, Tedeschi G, Weinberger DR (1996) Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. Am J Psychiatry 153: 1554-1563
    • (1996) Am J Psychiatry , vol.153 , pp. 1554-1563
    • Bertolino, A.1    Nawroz, S.2    Mattay, V.3    Barnett, A.4    Duyn, J.5    Moonen, C.6    Frank, J.A.7    Tedeschi, G.8    Weinberger, D.R.9
  • 11
    • 0033802818 scopus 로고    scopus 로고
    • Selective relationship between prefrontal N-acetylaspartate measures and negative symptoms in schizophrenia
    • Callicot J, Bertolino A, Egan M, Mattay V, Langheim F, Weinberger D (2000) Selective relationship between prefrontal N-acetylaspartate measures and negative symptoms in schizophrenia. Am J Psychiatry 157: 1646-1651
    • (2000) Am J Psychiatry , vol.157 , pp. 1646-1651
    • Callicot, J.1    Bertolino, A.2    Egan, M.3    Mattay, V.4    Langheim, F.5    Weinberger, D.6
  • 12
    • 0037013695 scopus 로고    scopus 로고
    • 2A receptor blockade plus L-DOPA in dopamine denervated rats
    • 2A receptor blockade plus L-DOPA in dopamine denervated rats. Synapse 44: 166-174
    • (2002) Synapse , vol.44 , pp. 166-174
    • Carta, A.1    Pinna, A.2    Cauli, O.3    Morelli, M.4
  • 15
    • 0026070134 scopus 로고
    • Dopamine in schizophrenia: A review and reconceptualization
    • Davis KL, Kahn RS, Ko G, Davidson M (1991) Dopamine in schizophrenia: a review and reconceptualization. Am J Psychiatry 148: 1474-1486
    • (1991) Am J Psychiatry , vol.148 , pp. 1474-1486
    • Davis, K.L.1    Kahn, R.S.2    Ko, G.3    Davidson, M.4
  • 17
    • 84931107766 scopus 로고
    • Amphetamine psychosis I. Description of the individuals and process
    • Ellinwood E (1976) Amphetamine psychosis I. Description of the individuals and process. J Nerv Ment Dis 144: 273-283
    • (1976) J Nerv Ment Dis , vol.144 , pp. 273-283
    • Ellinwood, E.1
  • 18
    • 85047700000 scopus 로고    scopus 로고
    • Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity
    • Farber N, Kim S, Dikranian K, Jiang X, Heinkel C (2002) Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity. Mol Psychiatry 7: 32-43
    • (2002) Mol Psychiatry , vol.7 , pp. 32-43
    • Farber, N.1    Kim, S.2    Dikranian, K.3    Jiang, X.4    Heinkel, C.5
  • 20
    • 0036269901 scopus 로고    scopus 로고
    • Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia
    • Heckers S, Stone D, Walsh J, Shick J, Koul P, Benes F (2002) Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia. Arch Gen Psychiatry 69: 521-529
    • (2002) Arch Gen Psychiatry , vol.69 , pp. 521-529
    • Heckers, S.1    Stone, D.2    Walsh, J.3    Shick, J.4    Koul, P.5    Benes, F.6
  • 22
    • 0025952455 scopus 로고
    • Recent advances in the phencyclidine model of schizophrenia
    • Javitt D, Zukin S (1991) Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148: 1301-1308
    • (1991) Am J Psychiatry , vol.148 , pp. 1301-1308
    • Javitt, D.1    Zukin, S.2
  • 24
    • 0019293020 scopus 로고
    • Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia
    • Kim JS, Kornhuber HH, Schmid-Burke W, Holzmüller B (1980) Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20: 379-382
    • (1980) Neurosci Lett , vol.20 , pp. 379-382
    • Kim, J.S.1    Kornhuber, H.H.2    Schmid-Burke, W.3    Holzmüller, B.4
  • 25
    • 0028323167 scopus 로고
    • Subanesthetic effects of the non-competitive NMDA antagonist, ketamine, in humans: Psychotomimetic perception, perceptual, cognitive and neuroendocrine responses
    • Krystal J, Karger L, Seibyl J, Freeman G, Delaney R, Bremner J, Heninger GR, Bowers MB, Charney D (1994) Subanesthetic effects of the non-competitive NMDA antagonist, ketamine, in humans: psychotomimetic perception, perceptual, cognitive and neuroendocrine responses. Arch Gen Psychiatry 51: 199-214
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 199-214
    • Krystal, J.1    Karger, L.2    Seibyl, J.3    Freeman, G.4    Delaney, R.5    Bremner, J.6    Heninger, G.R.7    Bowers, M.B.8    Charney, D.9
  • 27
    • 0028843997 scopus 로고
    • Differential regulation of mRNA levels encoding for the two isoforms of glutamate decarboxylase (GAD65 and GAD67) by dopamine receptors in the rat striatum
    • Laprade N, Soghomonian J (1995) Differential regulation of mRNA levels encoding for the two isoforms of glutamate decarboxylase (GAD65 and GAD67) by dopamine receptors in the rat striatum. Mol Brain Res 34: 65-74
    • (1995) Mol Brain Res , vol.34 , pp. 65-74
    • Laprade, N.1    Soghomonian, J.2
  • 28
    • 0034054794 scopus 로고    scopus 로고
    • The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies
    • Laruelle M (2000) The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studies. Brain Res Rev 31: 371-384
    • (2000) Brain Res Rev , vol.31 , pp. 371-384
    • Laruelle, M.1
  • 29
    • 0034850158 scopus 로고    scopus 로고
    • Lamina-specific deficits in parvalbumin-immunoreactive varicosities in the prefrontal cortex of subjects with schizophrenia: Evidence for fewer projections from the thalamus
    • Lewis D, Cruz D, Melchitzki D, Pierri J (2001) Lamina-specific deficits in parvalbumin-immunoreactive varicosities in the prefrontal cortex of subjects with schizophrenia: evidence for fewer projections from the thalamus. Am J Psychiatry 158: 1411-1422
    • (2001) Am J Psychiatry , vol.158 , pp. 1411-1422
    • Lewis, D.1    Cruz, D.2    Melchitzki, D.3    Pierri, J.4
  • 30
    • 0027377686 scopus 로고
    • Dopaminergic regulation of glutamic acid decarboxylase mRNA expression and GABA release in the striatum
    • Lindefors N (1993) Dopaminergic regulation of glutamic acid decarboxylase mRNA expression and GABA release in the striatum. Prog Neuropsychopharmacol Biol Psychiatry 17: 887-903
    • (1993) Prog Neuropsychopharmacol Biol Psychiatry , vol.17 , pp. 887-903
    • Lindefors, N.1
  • 31
    • 0026576094 scopus 로고
    • Amphetamine regulation of acetylcholine and gamma-aminobutyric acid in nucleus accumbens
    • Lindefors N, Hurd Y, O'Connor W, Brené S, Persson H, Ungerstedt U (1992) Amphetamine regulation of acetylcholine and gamma-aminobutyric acid in nucleus accumbens. Neurosci 48: 439-448
    • (1992) Neurosci , vol.48 , pp. 439-448
    • Lindefors, N.1    Hurd, Y.2    O'Connor, W.3    Brené, S.4    Persson, H.5    Ungerstedt, U.6
  • 32
    • 0034284828 scopus 로고    scopus 로고
    • To model a psychiatric disorder in animals: Schizophrenia as a reality test
    • Lipska B, Weinberger D (2000) To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacol 23: 223-229
    • (2000) Neuropsychopharmacol , vol.23 , pp. 223-229
    • Lipska, B.1    Weinberger, D.2
  • 33
    • 0027297279 scopus 로고
    • Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: A potential animal model of schizophrenia
    • Lipska B, Jaskiw G, Weinberger D (1993) Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia. Neuropsychopharmacol 9: 67-75
    • (1993) Neuropsychopharmacol , vol.9 , pp. 67-75
    • Lipska, B.1    Jaskiw, G.2    Weinberger, D.3
  • 34
    • 0021879046 scopus 로고
    • Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: Effect of anticonvulsant treatment
    • Loscher W, Siemes H (1985) Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: effect of anticonvulsant treatment. Epilepsia 26: 314-319
    • (1985) Epilepsia , vol.26 , pp. 314-319
    • Loscher, W.1    Siemes, H.2
  • 35
    • 0032032540 scopus 로고    scopus 로고
    • Non-NMDA excitatory amino acid receptors in the ventral tegmental area mediate systemic dizocilpine (MK-801) induced hyperlocomotion and dopamine release in the nucleus accumbens
    • Mathé J, Nomikos G, Schilstrom B, Svensson T (1998) Non-NMDA excitatory amino acid receptors in the ventral tegmental area mediate systemic dizocilpine (MK-801) induced hyperlocomotion and dopamine release in the nucleus accumbens. J Neurosci Res 51: 583-592
    • (1998) J Neurosci Res , vol.51 , pp. 583-592
    • Mathé, J.1    Nomikos, G.2    Schilstrom, B.3    Svensson, T.4
  • 36
    • 0015581657 scopus 로고
    • Antipsychotic drug actions: A clue to the neuropathology of schizophrenia?
    • Matthysse S (1973) Antipsychotic drug actions: a clue to the neuropathology of schizophrenia? Fed Proc 32: 200-205
    • (1973) Fed Proc , vol.32 , pp. 200-205
    • Matthysse, S.1
  • 38
    • 0032575715 scopus 로고    scopus 로고
    • Reversal of phencyclidine effects by group II metabotropic glutamate receptor agonist in rats
    • Moghaddam B, Adams B (1998) Reversal of phencyclidine effects by group II metabotropic glutamate receptor agonist in rats. Science 281: 1349-1352
    • (1998) Science , vol.281 , pp. 1349-1352
    • Moghaddam, B.1    Adams, B.2
  • 39
    • 0030900732 scopus 로고    scopus 로고
    • Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex
    • Moghaddam B, Adams B, Verma A, Daly D (1997) Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci 17: 2921-2927
    • (1997) J Neurosci , vol.17 , pp. 2921-2927
    • Moghaddam, B.1    Adams, B.2    Verma, A.3    Daly, D.4
  • 40
    • 0024338054 scopus 로고
    • Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs
    • Olney J, Labruyere J, Price M (1989) Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244: 1360-1362
    • (1989) Science , vol.244 , pp. 1360-1362
    • Olney, J.1    Labruyere, J.2    Price, M.3
  • 41
    • 0030813597 scopus 로고    scopus 로고
    • A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
    • Pierce R, Kalivas R (1997) A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Rev 25: 192-216
    • (1997) Brain Res Rev , vol.25 , pp. 192-216
    • Pierce, R.1    Kalivas, R.2
  • 42
    • 0028036305 scopus 로고
    • Dopaminergic and glutamatergic blocking drugs differentially regulate glutamic acid decarboxylase mRNA in mouse brain
    • Qin Z, Zhang S, Weiss B (1994) Dopaminergic and glutamatergic blocking drugs differentially regulate glutamic acid decarboxylase mRNA in mouse brain. Mol Brain Res 21: 293-302
    • (1994) Mol Brain Res , vol.21 , pp. 293-302
    • Qin, Z.1    Zhang, S.2    Weiss, B.3
  • 43
    • 0015422513 scopus 로고
    • Prospects for research on schizophrenia: An hypothesis suggesting that there is a defect in the GABA system in schizophrenia
    • Roberts E (1972) Prospects for research on schizophrenia: an hypothesis suggesting that there is a defect in the GABA system in schizophrenia. Neurosci Res Program Bull 10: 468-482
    • (1972) Neurosci Res Program Bull , vol.10 , pp. 468-482
    • Roberts, E.1
  • 44
    • 0035136421 scopus 로고    scopus 로고
    • Traditional and new antipsychotic drugs differentially alter neurotransmission markers in basal ganglia-thalamocortical neural pathways
    • Sakai K, Gao X, Hashimoto T, Tamminga C (2001) Traditional and new antipsychotic drugs differentially alter neurotransmission markers in basal ganglia-thalamocortical neural pathways. Synapse 39: 152-160
    • (2001) Synapse , vol.39 , pp. 152-160
    • Sakai, K.1    Gao, X.2    Hashimoto, T.3    Tamminga, C.4
  • 45
    • 0026539045 scopus 로고
    • Relapse of paranoid psychotic state in methamphetamine model of schizophrenia
    • Sato M, Numachi Y, Hamamura T (1992) Relapse of paranoid psychotic state in methamphetamine model of schizophrenia. Schiz Bull 18: 115-122
    • (1992) Schiz Bull , vol.18 , pp. 115-122
    • Sato, M.1    Numachi, Y.2    Hamamura, T.3
  • 47
    • 0030746306 scopus 로고    scopus 로고
    • Repeated binge exposures to amphetamine and methamphetamine: Behavioral and neurochemical charactrization
    • Segal D, Kuczenski R (1997) Repeated binge exposures to amphetamine and methamphetamine: behavioral and neurochemical charactrization. J Pharmacol Exp Ther 282: 561-573
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 561-573
    • Segal, D.1    Kuczenski, R.2
  • 48
    • 0029116492 scopus 로고
    • DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in rat cingulate and retrospinal cortex
    • Sharp J, Petersen D, Langford M (1995) DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in rat cingulate and retrospinal cortex. Brain Res 687: 114-124
    • (1995) Brain Res , vol.687 , pp. 114-124
    • Sharp, J.1    Petersen, D.2    Langford, M.3
  • 49
    • 0032526357 scopus 로고    scopus 로고
    • 67 expression in various regions of rat brain
    • 67 expression in various regions of rat brain. J Neurosci Res 52: 736-741
    • (1998) J Neurosci Res , vol.52 , pp. 736-741
    • Sheikh, S.N.1    Martin, D.L.2
  • 50
    • 0032416442 scopus 로고    scopus 로고
    • Two isoforms of glutamate decarboxylase: Why?
    • Soghomonian J, Martin D (1998) Two isoforms of glutamate decarboxylase: why? Trends Pharmacol Sci 19: 500-505
    • (1998) Trends Pharmacol Sci , vol.19 , pp. 500-505
    • Soghomonian, J.1    Martin, D.2
  • 51
    • 0021860968 scopus 로고
    • Subcellular distribution of glutamic acid decarboxylase in rat brain regions following electroconvulsive stimulation
    • Stelzer A, Laas R, Fleissner A (1985) Subcellular distribution of glutamic acid decarboxylase in rat brain regions following electroconvulsive stimulation. J Neural Transm 62: 99-106
    • (1985) J Neural Transm , vol.62 , pp. 99-106
    • Stelzer, A.1    Laas, R.2    Fleissner, A.3
  • 52
    • 0034011252 scopus 로고    scopus 로고
    • Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia
    • Volk D, Austin M, Pierri J, Sampson A, Lewis D (2000) Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Arch Gen Psychiatry 57: 237-245
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 237-245
    • Volk, D.1    Austin, M.2    Pierri, J.3    Sampson, A.4    Lewis, D.5
  • 53
    • 0036498524 scopus 로고    scopus 로고
    • Pubertal neurodevelopment and the emergence of psychotic symptoms
    • Walker E, Bollini A (2002) Pubertal neurodevelopment and the emergence of psychotic symptoms. Schiz Res 54: 17-23
    • (2002) Schiz Res , vol.54 , pp. 17-23
    • Walker, E.1    Bollini, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.