The MKK6-p38 MAPK pathway prolongs the cardiac contractile calcium transient, downregulates SERCA2, and activates NF-AT

Cardiovascular Research

Volumn 59, Issue 1, 2003, Pages 46-56

  Andrews, Catherine ^a   Ho, Peter D ^b   Dillmann, Wolfgang H ^c   Glembotski, Christopher C ^b   McDonough, Patrick M ^c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b SAN DIEGO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Ca pump; Calcium (cellular); Gene expression; Gene therapy; Signal transduction

Indexed keywords

CALCIUM ION; ENZYME ACTIVATOR; GLUTAMINE; GREEN FLUORESCENT PROTEIN; INDO 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; NUCLEAR FACTOR; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DIASTOLE; DOWN REGULATION; ENZYME ANALYSIS; ENZYME REGULATION; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HEART CONTRACTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE RELAXATION; HEART PACING; HEART VENTRICLE OVERLOAD; HEART VENTRICLE PRESSURE; MOLECULAR BIOLOGY; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; RAT; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CELLS, CULTURED; DNA-BINDING PROTEINS; ELECTRIC STIMULATION; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; IMAGE PROCESSING, COMPUTER-ASSISTED; LUMINESCENT PROTEINS; MAP KINASE KINASE 6; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCYTES, CARDIAC; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RNA, MESSENGER; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0038095180     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00329-8     Document Type: Article

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