Ras reduces L-type calcium channel current in cardiac myocytes: Corrective effects of L-channels and SERCA2 on [Ca2+]i regulation and cell morphology

Circulation Research

Volumn 88, Issue 1, 2001, Pages 63-69

  Ho, Peter D ^a   Fan, Jing Song ^b   Hayes, Nicole L ^a   Saada, Nehad ^b   Palade, Philip T ^b   Glembotski, Christopher C ^a   McDonough, Patrick M ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Cardiac hypertrophy; L type calcium channel; Ras; SERCA2

Indexed keywords

CALCIUM CHANNEL; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; HEART DISEASE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

EID: 0035910613     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.88.1.63     Document Type: Article

References (34)

1. Sarcoplasmic reticulum-related changes in cytosolic calcium in pressure-overload-induced feline LV hypertrophy
2. Depressed intracellular calcium transients and contraction in myocytes from hypertrophied and failing guinea pig hearts
3. Diastolic dysfunction in hypertrophic cardiomyopathy: Effect on active force generation during systole
4. Calcium transport proteins in the nonfailing and failing heart: Gene expression and function
5. Alterations in sarcoplasmic reticulum gene expression in human heart failure: A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium
6. 2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure
7. Ventricular action potential and L-type calcium channel in infarct-induced hypertrophy in rats
8. Calcium currents in diseased human cardiac cells
9. Electrophysiological remodeling in hypertrophy and heart failure
10. L-type calcium channel abundance and function with cardiac hypertrophy and failure: A review
11. Altered expression of titin and contractile proteins in failing human myocardium
12. Expression of cellular oncogenes in the myocardium during the developmental stage and pressure-overloaded hypertrophy of the rat heart
13. Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy
14. Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice
15. 1-adrenergic stimulation
16. 1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy
17. Increasing complexity of the Ras signaling pathway
18. A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression
19. A Ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: Implications for cardiac hypertrophy
20. The Raf-MEK-ERK cascade represents a common pathway for alteration of intracellular calcium by Ras and protein kinase C in cardiac myocytes
21. Regulation of DHP receptor expression by elements in the 5′-flanking sequence
22. Perforated patch recording with β-escin
23. Ultrastructural morphometric analysis of cultured neonatal and adult rat ventricular cardiac muscle cells
24. Intracellular calcium transients from newborn rat cardiomyocytes in primary culture
25. Inhibition of cloned human L-type cardiac calcium channels by 2,3-butanedione monoxime does not require PKA-dependent phosphorylation sites
26. Regulation of calcium channel expression in neonatal myocytes by catecholamines
27. Voltage-sensitive calcium channels in normal and transformed 3T3 fibroblasts
28. 2+ channel
29. p21 Ras as a governor of global gene expression
30. 2+ adenosine triphosphatase gene
31. A Raf-induced, MEK-independent signaling pathway regulates atrial natriuretic factor gene expression in cardiac muscle cells
32. 2+ channel in transgenic mice: Loss of isoproterenol-induced contraction
33. Calreticulin couples calcium release and calcium influx in integrin-mediated calcium signaling
34. 3β1 integrin isoforms in association with myofibrillo-genesis during cardiac myocyte development in culture