Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation

BMC Neuroscience

Volumn 4, Issue , 2003, Pages

  Xiang, Mengqing ^a   Maklad, Adel ^b   Pirvola, Ulla ^c   Fritzsch, Bernd ^b  

^a RUTGERS UNIVERSITY   (United States)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Afferent ear innervation; Ear development; Efferent ear innervation; POU factors and hair cells

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MYOSIN; NEUROTROPHIN 3;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL SURVIVAL; COCHLEA; CONTROLLED STUDY; EFFERENT NERVE; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE MUTATION; HAIR CELL; INNER EAR; MOUSE; MOUSE MUTANT; NEUROEPITHELIUM; NONHUMAN; POSTNATAL DEVELOPMENT; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SENSORY NERVE CELL;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARBOCYANINES; CELL COUNT; DYNEINS; EAR, INNER; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HAIR CELLS, AUDITORY, INNER; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MYOSINS; NEURONS, AFFERENT; NEUROTROPHIN 3; RNA, MESSENGER; SPIRAL GANGLION; TRANSCRIPTION FACTOR BRN-3C;

EID: 0038085356     PISSN: 14712202     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2202-4-2     Document Type: Article

References (43)

1. Erkman L, McEvilly RJ, Luo L, Ryan AK, Hooshmand F, O'Connell SM, Keithley EM, Rapaport DH, Ryan AF and Rosenfeld MG Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature 1996, 381:603-606
2. Xiang M, Gan L, Li D, Chen ZY, Zhou L, O'Malley BW Jr, Klein W and Nathans J Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A 1997, 94:9445-9450
3. Xiang M, Gao WQ, Hasson T and Shin JJ Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development 1998, 125:3935-3946
4. Fritzsch B, Pirvola U and Ylikoski J Making and breaking the innervation of the ear: neurotrophic support during ear development and its clinical implications. Cell Tissue Res 1999, 295:369-382
5. Rubel EW and Fritzsch B AUDITORY SYSTEM DEVELOPMENT: Primary Auditory Neurons and Their Targets. Annu Rev Neurosci 2002, 25:51-101
6. Farinas I, Jones KR, Tessarollo L, Vigers AJ, Huang E, Kirstein M, de Caprona DC, Coppola V, Backus C, Reichardt LF and Fritzsch B Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. J Neurosci 2001, 21:6170-6180
7. Pirvola U, Ylikoski J, Palgi J, Lehtonen E, Arumae U and Saarma M Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia. Proc Natl Acad Sci U S A 1992, 89:9915-9919
8. Ernfors P, Van De Water T, Loring J and Jaenisch R Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 1995, 14:1153-1164
9. Farinas I, Jones KR, Backus C, Wang XY and Reichardt LF Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature 1994, 369:658-661
10. Cosgaya JM, Chan JR and Shooter EM The neurotrophin receptor p75NTR as a positive modulator of myelination. Science 2002, 298:1245-1248
11. Hashino E, Dolnick RY and Cohan CS Developing vestibular ganglion neurons switch trophic sensitivity from BDNF to GDNF after target innervation. J Neurobiol 1999, 38:414-427
12. Vahava O, Morell R, Lynch ED, Weiss S, Kagan ME, Ahituv N, Morrow JE, Lee MK, Skvorak AB, Morton CC, Blumenfeld A, Frydman M, Friedman TB, King MC and Avraham KB Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans. Science 1998, 279:1950-1954
13. Bianchi LM, Conover JC, Fritzsch B, DeChiara T, Lindsay RM and Yancopoulos GD Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice. Development 1996, 122:1965-1973
14. Fritzsch B, Farinas I and Reichardt LF Lack of neurotrophin 3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion. J Neurosci 1997, 17:6213-6225
15. Fritzsch B, Silos-Santiago I, Bianchi LM and Farinas I The role of neurotrophic factors in regulating the development of inner ear innervation. Trends Neurosci 1997, 20:159-164
16. Fritzsch B, Barbacid M and Silos-Santiago I The combined effects of trkB and trkC mutations on the innervation of the inner ear. Int J Dev Neurosci 1998, 16:493-505
17. Zine A, Aubert A, Qiu J, Therianos S, Guillemot F, Kageyama R and de Ribaupierre F Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear. J Neurosci 2001, 21:4712-4720
18. Pirvola U, Ylikoski J, Trokovic R, Hebert J, McConnell S and Partanen J FGFR1 Is Required for the Development of the Auditory Sensory Epithelium. Neuron 2002, 35:671
19. Leake PA, Snyder RL and Hradek GT Postnatal refinement of auditory nerve projections to the cochlear nucleus in cats. J Comp Neurol 2002, 448:6-27
20. Wheeler EF, Bothwell M, Schecterson LC and von Bartheld CS Expression of BDNF and NT-3 mRNA in hair cells of the organ of Corti: quantitative analysis in developing rats. Hear Res 1994, 73:46-56
21. Levi-Montalcini R The nerve growth factor 35 years later. Science 1987, 237:1154-1162
22. Xiang M, Gan L, Li D, Zhou L, Chen ZY, Wagner D, O'Malley BW Jr, Klein W and Nathans J Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. Cold Spring Harb Symp Quant Biol 1997, 62:325-336
23. Ylikoski J, Pirvola U, Moshnyakov M, Palgi J, Arumae U and Saarma M Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear. Hear Res 1993, 65:69-78
24. Tierney TS, T PD, Xia G and Moore DR Development of brain-derived neurotrophic factor and neurotrophin-3 immunoreactivity in the lower auditory brainstem of the postnatal gerbil. Eur J Neurosci 2001, 14:785-793
25. Heid S, Hartmann R and Klinke R A model for prelingual deafness, the congenitally deaf white cat - population statistics and degenerative changes. Hear Res 1998, 115:101-112
26. Colvin JS, Bohne BA, Harding GW, McEwen DG and Ornitz DM Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet 1996, 12:390-397
27. Pirvola U, Spencer-Dene B, Xing-Qun L, Kettunen P, Thesleff I, Fritzsch B, Dickson C and Ylikoski J FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis. J Neurosci 2000, 20:6125-6134
28. Eddison M, Le Roux I and Lewis J Notch signaling in the development of the inner ear: lessons from Drosophila. Proc Natl Acad Sci U S A 2000, 97:11692-11699
29. Fritzsch B, Beisel KW and Bermingham NA Developmental evolutionary biology of the vertebrate ear: conserving mechanoelectric transduction and developmental pathways in diverging morphologies. Neuroreport 2000, 11:R35-44
30. Kim WY, Fritzsch B, Serls A, Bakel LA, Huang EJ, Reichardt LF, Barth DS and Lee JE NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development 2001, 128:417-426
31. Karis A, Pata I, van Doorninck JH, Grosveld F, de Zeeuw CI, de Caprona D and Fritzsch B Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. J Comp Neurol 2001, 429:615-630
32. Ma Q, Anderson DJ and Fritzsch B Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation. J Assoc Res Otolaryngol 2000, 1:129-143
33. Coppola V, Kucera J, Palko ME, Martinez-De Velasco J, Lyons WE, Fritzsch B and Tessarollo L Dissection of NT3 functions in vivo by gene replacement strategy. Development 2001, 128:4315-4327
34. Frydman M, Vreugde S, Nageris BI, Weiss S, Vahava O and Avraham KB Clinical characterization of genetic hearing loss caused by a mutation in the POU4F3 transcription factor. Arch Otolaryngol Head Neck Surg 2000, 126:633-637
35. Keithley EM, Erkman L, Bennett T, Lou L and Ryan AF Effects of a hair cell transcription factor, Brn-3.1, gene deletion on homozygous and heterozygous mouse cochleas in adulthood and aging. Hear Res 1999, 134:71-76
36. Yagi M, Kanzaki S, Kawamoto K, Shin B, Shah PP, Magal E, Sheng J and Raphael Y Spiral ganglion neurons are protected from degeneration by GDNF gene therapy. J Assoc Res Otolaryngol 2000, 1:315-325
37. Bermingham NA, Hassan BA, Price SD, Vollrath MA, Ben-Arie N, Eatock RA, Bellen HJ, Lysakowski A and Zoghbi HY Math1: an essential gene for the generation of inner ear hair cells. Science 1999, 284:1837-1841
38. Liberman MC, Gao J, He DZ, Wu X, Jia S and Zuo J Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature 2002, 419:300-304
39. Li S, Price SM, Cahill H, Ryugo DK, Shen MM and Xiang M Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Development 2002, 129:3523-3532
40. Qun LX, Pirvola U, Saarma M and Ylikoski J Neurotrophic factors in the auditory periphery. Ann N Y Acad Sci 1999, 884:292-304
41. Fritzsch B and Nichols DH DiI reveals a prenatal arrival of efferents at the differentiating otocyst of mice. Hear Res 1993, 65:51-60
42. Fritzsch B, Christensen MA and Nichols DH Fiber pathways and positional changes in efferent perikarya of 2.5- to 7-day chick embryos as revealed with DiI and dextran amines. J Neurobiol 1993, 24:1481-1499
43. Maklad A and Fritzsch B The developmental segregation of posterior crista and saccular vestibular fibers in mice: A carbocyanine tracer study using confocal microscopy. Develop Brain Research 2002, 135:1-17