Cholesterol attenuates linoleic acid-induced endothelial cell activation

Metabolism: Clinical and Experimental

Volumn 52, Issue 4, 2003, Pages 493-500

  Meerarani, Purushothaman ^a,b   Smart, Eric J ^a,b   Toborek, Michal ^a,b   Boissonneault, Gilbert A ^a,b   Hennig, Bernhard ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE; CHOLESTEROL; FATTY ACID; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LINOLEIC ACID; NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; CELL RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; OXIDIZING AGENT; TRANSCRIPTION FACTOR;

ARTICLE; ATHEROSCLEROSIS; CELL ACTIVATION; CELL LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; DOWN REGULATION; DRUG EFFECT; ENDOTHELIUM CELL; ENDOTHELIUM LESION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INCUBATION TIME; PRIORITY JOURNAL; PULMONARY ARTERY; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR ENDOTHELIUM; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CULTURE MEDIUM; CYTOLOGY; GEL MOBILITY SHIFT ASSAY; GENETICS; INFLAMMATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE;

ANIMALS; CELLS, CULTURED; CHOLESTEROL; CULTURE MEDIA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOTHELIUM, VASCULAR; GLUTATHIONE; INFLAMMATION; INTERLEUKIN-6; LINOLEIC ACID; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; OXIDANTS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SWINE; TRANSCRIPTION FACTORS;

EID: 0038075280     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2003.50087     Document Type: Article

References (48)

1. Mensink RP: Effects of the individual saturated fatty acids on serum lipids and lipoprotein concentrations. Am J Clin Nutr 57:711S-14S, 1993 (suppl)
2. Yli-Jama P, Meyer HE, Ringstad J, et al: Serum free fatty acid pattern and risk of myocardial infarction: A case-control study. J Intern Med 251:19-28, 2002
3. Kok FJ, Van Poppel G, Melse J, et al: Do antioxidants and polyunsaturated fatty acids have a combined association with coronary atherosclerosis? Atherosclerosis 31:85-90, 1991
4. Woo Lee Y, Joo Park H, Hennig B, et al: Linoleic acid induces MCP-1 gene expression in human microvascular endothelial cells through an oxidative mechanism. J Nutr Biochem 12:648-654, 2001
5. Yam D, Eliraz A, Berry EM: Diet and disease, the Israeli paradox: Possible dangers of a high omega-6 polyunsaturated fatty acid diet. Isr J Med Sci 32:1134-1143, 1996
6. Loustarinen R, Boberg M, Saldeen T: Fatty acid composition in total phospholipids of human coronary arteries in sudden cardiac death. Atherosclerosis 99:187-193, 1993
7. Pietsch A, Weber C, Goretzki M, et al: N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocyte cells. Cell Biochem Funct 13: 211-216, 1995
8. Vallve JC, Uliaque K, Girona J, et al: Unsaturated fatty acids and their oxidation products stimulate CD36 gene expression in human macrophages. Atherosclerosis 164:45-56, 2002
9. Hodgson JM, Wahlqvist ML, Boxall JA, et al: Can linoleic acid contribute to coronary artery disease? Am J Clin Nutr 58:228-234, 1993
10. Hennig B, Shasby DM, Spector AA: Exposure to fatty acid increases human low density lipoprotein transfer across cultured endothelial monolayers. Circ Res 57:776-780, 1985
11. Hennig B, Meerarani P, Ramadass R, et al: Fatty acid-mediated activation of vascular endothelial cells. Metabolism 49:1006-1013, 2000
12. Toborek M, Barger SW, Mattson MP, et al: Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells. J Lipid Res 37:123-135, 1996
13. Nicholas KN, Toborek M, Slim S, et al: Dietary cholesterol supplementation protects against endothelial cell dysfunction mediated by native and lipolyzed lipoproteins derived from rabbits fed high-corn oil diets. J Nutr Biochem 8:566-572, 1997
14. Peterson TE, Poppa V, Ueba H, et al: Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae. Circ Res 85:29-37, 1999
15. Corvera S, DiBonaventura C, Shpetner HS: Cell confluence-dependent remodeling of endothelial membranes mediated by cholesterol. J Biol Chem 275:31414-31421, 2000
16. Gimpl G, Burger K, Fahrenholz F: Cholesterol as modulator of receptor function. Biochemistry 36:10959-10974 1997
17. Furuchi T, Anderson RG: Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK). J Biol Chem 273:21099-21104, 1998
18. Pike LJ, Miller JM: Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J Biol Chem 273:22298-22304, 1998
19. Lazar MA: Progress in cardiovascular biology: PPAR for the course. Nat Med 7:23-24, 2001
20. Hennig B, Shasby DM, Fulton AB, et al: Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. Arteriosclerosis 4:489-497, 1984
21. Hennig B, Boissonneault GA: Cholestan-3 beta,5 alpha,6 beta-triol decreases barrier function of cultured endothelial cell monolayers. Atherosclerosis 68:255-261, 1987
22. Uittenbogaard A, Shaul PW, Yuhanna IS, et al: High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae. J Biol Chem 275:11278-11283, 2000
23. Baker MA, Cerniglia GJ, Zaman A: Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem 190:360-365, 1990
24. Beg AA, Finco TS, Nantermet PV, et al: Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: A mechanism for NF-kappa B activation. Mol Cell Biol 13:3301-3310, 1993
25. Hennig B, Meerarani P, Slim R, et al: Proinflammatory properties of coplanar PCBs: In vitro and in vivo evidence. Toxicol Appl Pharmacol 181:174-183, 2002
26. Barchowsky A, Roussel RR, Krieser RJ, et al: Expression and activity of urokinase and its receptor in endothelial and pulmonary epithelial cells exposed to asbestos. Toxicol Appl Pharmacol 152:388-396, 1998
27. Davda RK, Chandler LJ, Crews FT, et al: Ethanol enhances the endothelial nitric oxide synthase response to agonists. Hypertension 21:939-943, 1993
28. Chilton RJ: Recent discoveries in assessment of coronary heart disease: Impact of vascular mechanisms on development of atherosclerosis. Am Osteopath Assoc 101:S1-5, 2001 (suppl 9)
29. Barton M, Haudenschild CC: Endothelium and atherogenesis: Endothelial therapy revisited. J Cardiovasc Pharmacol 38:S23-25, 2001 (suppl)
30. Yamaoka J, Kabashima K, Kawanishi M, et al: Cytotoxicity of IFN-gamma and TNF-alpha for vascular endothelial cells is mediated by nitric oxide. Biochem Biophys Res Commun 291:780-786, 2002
31. Serhan CN, Haeggström JZ, Leslie CC: Lipid mediator networks in cell signaling: Update and impact of cytokines. FASEB J 10:1147-1158, 1996
32. Cohn JS: Postprandial lipemia: Emerging evidence for atherogenicity of remnant lipoproteins. Can J Cardiol 14:18B-27B, 1998 (suppl)
33. Boquist S, Ruotolo G, Tang R, et al: Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation 100:723-728, 1999
34. Kusterer K, Pohl T, Fortmeyer HP, et al: Chronic selective hypertriglyceridemia impairs endothelium-dependent vasodilatation in rats. Cardiovasc Res 42:783-793, 1999
35. De Gruijter M, Hoogerbrugge N, Van Rijn MA, et al: Patients with combined hypercholesterolemia-hypertriglyceridemia show an increased monocyte-endothelial cell adhesion in vitro: Triglyceride level as a major determinant. Metabolism 40:1119-1121, 1991
36. Dart AM, Chin-Dusting JP: Lipids and the endothelium. Cardiovasc Res 43:308-322, 1999
37. Doi H, Kugiyama K, Oka H, Sugiyama S, et al: Remnant lipoproteins induce proatherothrombogenic molecules in endothelial cells through a redox-sensitive mechanism. Circulation 102:670-676, 2000
38. Hennig B, Toborek M, McClain CJ, et al: Nutritional implications in vascular endothelial cell metabolism. J Am Coll Nutr 15:345-358, 1996
39. Hennig B, Alvarado A, Ramasamy S, et al: Fatty acid induced disruption of endothelial barrier function in culture. Biochem Arch 6:409-417, 1990
40. Hennig B, Ramasamy S, Alvarado A, et al: Selective disruption of endothelial barrier function in culture by pure fatty acids and fatty acids derived from animal and plant fats. J Nutr 123:1208-1216, 1993
41. Smith LL: Another cholesterol hypothesis: Cholesterol as antioxidant. Free Radic Biol Med 11:47-61, 1991
42. Fruchart JC, Duriez P, Staels B: Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol 10:245-257, 1999
43. Chinetti G, Fruchart JC, Staels B: Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 49:497-505, 2000
44. Poynter ME, Daynes RA: Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 273:32833-32841, 1998
45. Chinetti G, Lestavel S, Bocher V, et al: PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 7:53-58, 2001
46. Brovkovych V, Dobrucki LW, Brovkovych S, et al: Nitric oxide release from normal and dysfunctional endothelium. J Physiol Pharmacol 50:575-586, 1999
47. Hennig B, Toborek M, Joshi-Barve S, et al: Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells. Am J Clin Nutr 63:322-328, 1996
48. Blair A, Shaul PW, Yuhanna IS, et al: Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation. J Biol Chem 274:32512-32519, 1999