Solid phase β-lactams synthesis using the Staudinger reaction, monitored by 19F NMR spectroscopy

Tetrahedron

Volumn 59, Issue 21, 2003, Pages 3719-3727

  Le Roy, Isabelle ^a   Mouysset, Dominique ^a   Mignani, Serge ^b   Vuilhorgne, Marc ^b   Stella, Lucien ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b SANOFI   (France)

Author keywords

19F NMR spectroscopy; Solid phase synthesis; Staudinger cycloaddition; amino esters; lactams

Indexed keywords

ALDEHYDE DERIVATIVE; ALPHA AMINO ACID; BENZALDEHYDE DERIVATIVE; BETA LACTAM DERIVATIVE; CHLORIDE; ESTER DERIVATIVE; FLUORINE; IMINE; METHYL(3 BENZYLOXY 2 OXO 3 PHENYLAZETIDIN 1 YL) 3 (4 FLUOROPHENYL)PROPIONATE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CYCLOADDITION; DEPROTECTION REACTION; FLUORINATION; LIQUID; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERIZATION; PRIORITY JOURNAL; REACTION ANALYSIS; SEQUENCE ANALYSIS; SOLID; STAUDINGER REACTION; TECHNIQUE;

EID: 0038061451     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(03)00553-2     Document Type: Article

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