Influence of resin structure, tether length, and solvent upon the high-resolution 1H NMR spectra of solid-phase-synthesis resins

Journal of Organic Chemistry

Volumn 61, Issue 5, 1996, Pages 1558-1559

  Keifer, Paul A ^a  

^a Varian Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000012760     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo952001t     Document Type: Article

References (10)

1. (a) Lloyd-Williams, P.; Albericio, F.; Giralt, E. Tetrahedron 1993, 49(48), 11065-11133.
2. (b) Madden, D.; Krchnák, V.; Lebl, M. Perspect. Drug Discovery Des 1994, 2, 269-285.
3. Lebl, M., Krchnák, V.; Sepetov, N. F.; Seligmann, B.; Strop, P.; Felder, S.; Lam, K. S. Biopolymers 1995, 37, 177-198.
4. Fitch, W. L.; Detre, G ; Holmes, C. P.; Shoolery, J. N.; Keifer, P. A. J. Org. Chem. 1994, 59, 7955-6.
5. All obtained from Calbiochem-Novabiochem (La Jolla, CA).
6. Keifer, P. A.; Baltusis, L.; Rice, D. M.; Tymiak, A. A.; Shoolery, J. N. J. Magn. Reson., Ser. A, 1996, in press.
7. Sarkar, S. K.; Garigipati, R. S.; Adams, J. L.; Keifer, P. A. J. Am. Chem. Soc. 1996, in press.
8. All other resins produced roughly equivalent spectra at any spin rate > 1 kHz, although (< 0.5%) sidebands of particularly large peaks could often be observed. All spectra shown here used spin rates of approximately 2 kHz.
9. This is presumably due to spin diffusion throughout the regions of the resin which have very different correlation times from the organic moeity.
10. 6) was measured several times during this study; a typical result was 1.2, 12.9, and 16.5 Hz (50%, 0.55%, and 0.11% levels, respectively).