Protease-activated receptors: The role of cell-surface proteolysis in signalling

Essays in Biochemistry

Volumn 38, Issue , 2002, Pages 169-183

  Cottrell, Graeme S ^a   Coelho, Anne Marie ^a   Bunnett, Nigel W ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; PROTEINASE INHIBITOR;

AMINO TERMINAL SEQUENCE; BIOAVAILABILITY; BLOOD CLOTTING; CELL MOTILITY; CELL SECRETION; CELL SHAPE; CELL SURFACE; CIRCULATION; DRUG SELECTIVITY; ENZYME ACTIVATION; HEALING; HUMAN; INFLAMMATION; INFLAMMATORY CELL; INJURY; LYSOSOME; PAIN; PROTEIN BINDING; PROTEIN DEGRADATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0038056146     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/bse0380169     Document Type: Review

References (25)

1. Coughlin, S.R. (2000) Thrombin signalling and protease-activated receptors. Nature (London) 407, 258-264
2. Macfarlane, S.R., Seatter, M.J., Kanke, T., Hunter, G.D. & Plevin, R. (2001) Proteinase-activated receptors. Pharmacol. Rev. 53, 245-282
3. Vergnolle, N. (2000) Proteinase-activated receptors - novel signals for gastrointestinal pathophysiology. Aliment. Pharmacol. Ther. 14, 257-266
4. Cocks, T.M. & Moffatt, J.D. (2000) Protease-activated receptors: sentries for inflammation? Trends Pharmacol. Sci. 21, 103-108
5. Vu, T.K., Hung, D.T., Wheaton, V.I. & Coughlin, S.R. (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64, 1057-1068
6. Xu, W., Andersen, H., Whitmore, T.E., Presnell, S.R., Yee, D.P., Ching, A., Gilbert, T., Davie, E.W. & Foster, D.C. (1998) Cloning and characterization of human protease-activated receptor 4. Proc. Natl. Acad. Sci. U.S.A. 95, 6642-6646
7. Nystedt, S., Emilsson, K., Wahlestedt, C. & Sundelin, J. (1994) Molecular cloning of a potential proteinase activated receptor. Proc. Natl. Acad. Sci. U.S.A. 91, 9208-9212
8. Molino, M., Barnathan, E.S., Numerof, R., Clark, J., Dreyer, M., Cumashi, A., Hoxie, J., Schechter, N., Woolkalis, M. & Brass, L.F. (1997) Interactions of mast cell tryptase with thrombin receptors and PAR-2. J. Biol. Chem. 272, 4043-4049
9. Camerer, E., Huang, W. & Coughlin, S.R. (2000) Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc. Natl. Acad. Sci. U.S.A. 97, 5255-5260
10. Bono, F., Schaeffer, P., Herault, J.P., Michaux, C., Nestor, A.L., Guillemot, J.C. & Herbert, J.M. (2000) Factor Xa activates endothelial cells by a receptor cascade between EPR-1 and PAR-2. Arterioscler. Thromb. Vasc. Biol. 20, E107-E112
11. Compton, S.J., Cairns, J.A., Palmer, K.J., Al-Ani, B., Hollenberg, M.D. & Walls, A.F. (2000) A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists. J. Biol. Chem. 275, 39207-39212
12. Compton, S.J., Renaux, B., Wijesuriya, S.J. & Hollenberg, M.D. (2001) Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase. Br. J. Pharmacol. 134, 705-718
13. Ishii, K., Hein, L, Kobilka, B. & Coughlin, S.R. (1993) Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. J. Biol. Chem. 268, 9780-9786
14. Dery, O., Thoma, M.S., Wong, H., Grady, E.F. & Bunnett, N.W. (1999) Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein, beta-Arrestin-dependent endocytosis of a proteinase receptor. J. Biol. Chem. 274, 18524-18535
15. DeFea, K.A., Zalevsky, J., Thoma, M.S., Dery, O., Mullins, R.D. & Bunnett, N.W. (2000) Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK 1/2. J. Cell Biol. 148, 1267-1281
16. Steinhoff, M., Vergnolle, N., Young, S.H., Tognetto, M., Amadesi, S., Ennes, H.S., Trevisani, M., Hollenberg, M.D., Wallace, J.L., Caughey, G.H. et al. (2000) Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat. Med. 6, 151-158
17. Vergnolle, N., Bunnett, N.W., Sharkey, K.A., Brussee, V., Compton, S.J., Grady, E.F., Cirino, G., Gerard, N., Basbaum, A.I., Andrade-Gordon, P. et al. (2001) Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat. Med. 7, 821-826
18. Cocks, T.M., Fong, B., Chow, J.M., Anderson, G.P., Frauman, A.G., Goldie, R.G., Henry, P.J., Carr, M.J., Hamilton, J.R. & Moffatt, J.D. (1999) A protective role for protease-activated receptors in the airways. Nature (London) 398, 156-160
19. Cocks, T.M. & Moffatt, J.D. (2001) Protease-activated receptor-2 (PAR2) in the airways. Pulm. Pharmacol. Ther. 14, 183-191
20. Napoli, C., Cicala, C., Wallace, J.L., de Nigris, F., Santagada, V., Caliendo, G., Franconi, F., Ignarro, L.J. & Cirino, G. (2000) Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart. Proc Natl. Acad. Sci. U.S.A. 97, 3678-3683
21. Kawabata, A., Kinoshita, M., Nishikawa, H., Kuroda, R., Nishida, M., Araki, H., Arizono, N., Oda, Y. & Kakehi, K. (2001) The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. J. Clin. Invest 107, 1443-1450
22. Andrade-Gordon, P., Derian, C.K., Maryanoff, B.E., Zhang, H.C., Addo, M.F., Cheung, W., Damiano, B.P., D'Andrea, M.R., Darrow, A.L., de Garavilla, L. et al. (2001) Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats. J. Pharmacol. Exp. Ther. 298, 34-42
23. Griffin, C.T., Srinivasan, Y., Zheng, Y.W., Huang, W. & Coughlin, S.R. (2001) A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 293, 1666-1670
24. Even-Ram, S., Uziely, B., Cohen, P., Grisaru-Granovsky, S., Maoz, M., Ginzburg, Y., Reich, R., Vlodavsky, I. & Bar-Shavit, R. (1998) Thrombin receptor overexpression in malignant and physiological invasion processes. Nat. Med. 4, 909-914
25. Vergnolle, N., Wallace, J.L., Bunnett, N.W. & Hollenberg, M.D. (2001) Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol. Sci. 22, 146-152