A role of protein kinase Cμ in signalling from the human adenosine A1 receptor to the nucleus

British Journal of Pharmacology

Volumn 139, Issue 4, 2003, Pages 721-732

  Hill, Kathryn J ^a   Webber, Anne C ^a   Hill, Stephen J ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

c fos; Gene transcription; MAP kinase; PKC ; Protein kinase C; Reporter genes

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 6 N CYCLOPENTYLADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; LUCIFERASE; PERTUSSIS TOXIN; PHORBOL DIBUTYRATE; PHORBOL ESTER DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN C FOS; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C IOTA; PROTEIN KINASE C MU; PROTEIN KINASE C ZETA; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CELL NUCLEUS; CHO CELL; CONCENTRATION RESPONSE; DOWN REGULATION; GENE ACTIVATION; GENE CONTROL; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; SIGNAL TRANSDUCTION;

ADENOSINE; ANIMALS; CELL NUCLEUS; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; GENE EXPRESSION REGULATION; GENES, FOS; HUMANS; ISOENZYMES; LUCIFERASES; MAP KINASE SIGNALING SYSTEM; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTOR, ADENOSINE A1; TRANSCRIPTION, GENETIC;

EID: 0038002354     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705294     Document Type: Article

References (40)

1. ALESSI, D.R. (1997). The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1β (Rsk-2) and p70 S6 kinase. FEBS Lett., 402, 121 - 123.
2. ARAI, H. & ESCOBEDO, J.A. (1996). Angiotensin II type 1 receptor signals through raf-1 by a protein kinase C dependent, ras independent mechanism. Mol. Pharmacol., 50, 522 - 528.
3. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein - dye binding. Anal. Biochem., 72, 248 - 254.
4. DICKENSON, J.M. & HILL, S.J. (1998). Involvement of G-protein Bγ subunits in coupling the adenosine A, receptor to phospholipase C in transfected CHO cells. Eur. J. Pharmacol., 355, 85 - 93.
5. 2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells. Br. J. Pharmacol., 124, 1491 - 1499.
6. DUDLEY, D.T., PANG, L., DECKER, S.J., BRIDGES, A.J. & SALTIEL, A.R. (1995). A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U.S.A., 92, 7686 - 7689.
7. EDWARDS, D.R. (1994). Cell signalling and the control of gene transcription. TIPS, 15, 239 - 244.
8. GSCHWENDT, M., DIETERICH, S., RENNECKE, J., KITTSTEIN, W., MUELLER, H.J. & JOHANNES, F.J. (1996). Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase C isoenzymes. FEBS Lett., 392, 77 - 80.
9. HAUSSER, A., STORZ, P., HUBNER, S., BRAENDLIN, I., MARTINEZ-MOYA, M., LINK, G. & JOHANNES, F.J. (2001). Protein kinase Cμ selectively activates the mitogen-activated protein kinase (MAPK) p42 pathway. FEBS Lett., 492, 39 - 45.
10. Q-mediated mitogen-activated protein kinase activation. J. Biol. Chem., 270, 17148 - 17153.
11. HILL, C.S. & TREISMAN, R. (1995). Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G-proteins and polypeptide growth-factors. EMBO. J., 14, 5037 - 5047.
12. HILL, S.J., GANELLIN, C.R., TIMMERMAN, H., SCHWARTZ, J.C., SHANKLEY, N.P., YOUNG, J.M., SCHUNACK, W., LEVI, R. & HAAS, H.L. (1997). International Union of Pharmacology XIII. Classification of histamine receptors. Pharmacol. Rev., 49, 253 - 278.
13. JOHANNES, F.J., PRESTLE, J., EIS, S., OBERHAGEMANN, P. & PFIZENMAIER, K. (1994). Protein kinase Cμ is a novel, atypical member of the protein kinase C family. J. Biol. Chem., 269, 6140 - 6148.
14. KARIN, M. & SMEAL, T. (1992). Control of transcription factors by signal transduction pathways: the beginning of the end. Trends Biochem. Sci., 17, 418 - 422.
15. 3 muscarinic receptor. Biochem. J., 337, 275 - 280.
16. LOWRY, O.H., ROSENBROUGH, N.J., FARR, A.C. & RANDALL, R.J. (1951). Protein measurements with the folin phenol reagent. J. Biol. Chem., 193, 265 - 275.
17. MACKENZIE, S., FLEMING, I., HOUSLAY, M.D., ANDERSON, N.G. & KILGOUR, E. (1997). Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-F442A cells. Biochem. J., 324, 159 - 165.
18. MARTINY-BARON, G., KAZANIETZ, M.G., MISCHAK, H., BLUMBERG, P.M., KOCHS, G., HUG, H., MARME, D. & SCHACHTELE, C. (1993). Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J. Biol. Chem., 268, 9194 - 9197.
19. 2-purinoceptors in CHO-K1 cells. Br. J. Pharmacol., 115, 1415 - 1424.
20. 1-receptor to the nucleus. Mol. Pharmacol., 59, 1012 - 1021.
21. MELLOR, H. & PARKER, P.J. (1998). The extended protein kinase C superfamily. Biochem. J., 332, 281 - 292.
22. NEWTON, A.C. (1995). Protein kinase C - structure, function, and regulation. J. Biol. Chem., 270, 28495 - 28498.
23. PAOLUCCI, L., SINNETT-SMITH, J. & ROZENGURT, E. (2000). Lysophosphatidic acid rapidly induces protein kinase D activation through a pertussis toxin-sensitive pathway. Am. J. Physiol. - Cell Physiol., 278, C33 - C39.
24. PRICE, M.A., HILL, C.S. & TREISMAN, R. (1996). Integration of growth factor signals at the c-fos serum response element. Philos. Trans. R. Soc. Ser. B: Biol. Sci., 351, 551 - 559.
25. ROBINSON, M.J. & COBB, M.H. (1997). Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol., 9, 180 - 186.
26. SELBIE, L.A. & HILL, S.J. (1998). G-protein-coupled receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends Pharmacol. Sci., 19, 87 - 98.
27. i/o-coupled receptors. Biochem. J., 328, 153 - 158.
28. SHAW, P.E., SCHROTER, H. & NORDHEIM, A. (1989). The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter. Cell, 56, 563 - 572.
29. SOH, J.W., LEE, E.H., PRYWES, R. & WEINSTEIN, I.B. (1999). Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element. Mol. Cell. Biol., 19, 1313 - 1324.
30. STANDAERT, M.L., GALLOWAY, L., KARNAM, P., BANDYOPADHYAY, G., MOSCAT, J. & FARESE, R.V. (1997). Protein kinase ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in adipocytes. J. Biol. Chem., 272, 30075 - 30082.
31. UEDA, Y., HIRAI, S., OSADA, S. & SUZUKI, A. (1996). Protein kinase Cδ activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem., 271, 23512 - 23519.
32. o-protein α-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. J. Biol. Chem., 271, 1266 - 1269.
33. VLAHOS, C.J., MATTER, W.F., HUI, K.Y. & BROWN, R.F. (1994). A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (Ly294002). J. Biol. Chem., 269, 5241 - 5248.
34. WAY, K.J., CHOU, E. & KING, G.L. (2000). Identification of PKC-isoform-specific biological actions using pharmacological approaches. Trends Pharmacol. Sci., 21, 181 - 187.
35. WHITMARSH, A.J., SHORE, P., SHARROCKS, A.D. & DAVIS, R.J. (1995). Integration of MAP kinase signal transduction pathways at the serum response element. Science, 269, 403 - 407.
36. WILKINSON, S.E., PARKER, P.J. & NIXON, J.S. (1993). Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem. J., 294, 335 - 337.
37. WYMANN, M.P., BULGARELLI-LEVA, G., ZVELEBIL, M.J., PIROLA, L., VANHAESEBROECK, B., WATERFIELD, M.D. & PANAYOTOU, G. (1996). Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol. Cell. Biol., 16, 1722 - 1733.
38. YANO, H., NAKANISHI S., KINUM, K., HANAI, N., SAITOH, Y., FUKUI, Y., NONOMURA, Y. & MATSUDA, Y. (1993). Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RB1-2H3 cells. J. Biol. Chem., 268, 25846 - 25856.
39. ZUGAZA, J.L., SINNETT-SMITH, J., VAN LINT, J. & ROZENGURT, E. (1996). Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway. EMBO. J., 15, 6220 - 6230.
40. ZUGAZA, J.L., WALDRON, R.T., SINNETT-SMITH, J. & ROZENGURT, E. (1997). Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway. J. Biol. Chem., 272, 23952 - 23960.