Encapsulation of packaging cell line results in succesful retroviral-mediated transfer of a suicide gene in vivo in an experimental model of glioblastoma

European Journal of Surgical Oncology

Volumn 29, Issue 4, 2003, Pages 351-357

  Martinet, Oliver ^a   Schreyer, N ^a   Reis, E D ^b   Joseph, J M ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Gene therapy; Glioblastoma; Herpes simplex virus; Retrovirus; Suicide gene; Thymidine kinase

Indexed keywords

GANCICLOVIR; RETROVIRUS VECTOR; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL ENCAPSULATION; CELL LINE; CELL STRAIN BHK; CONTROLLED STUDY; CULTURE MEDIUM; DNA PACKAGING; EXPERIMENTAL MODEL; GENE TRANSFER; GENETIC TRANSFECTION; GENOMIC IN SITU HYBRIDIZATION; GLIOBLASTOMA; HERPES SIMPLEX VIRUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROCAPSULE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; STEREOTAXIC SURGERY; SUICIDE GENE THERAPY; TARGET CELL; TUMOR NECROSIS; TUMOR VOLUME; VIRAL GENE DELIVERY SYSTEM; XENOGRAFT;

EID: 0037974766     PISSN: 07487983     EISSN: None     Source Type: Journal    
DOI: 10.1053/ejso.2002.1386     Document Type: Article

References (30)

1. Moolten FL. Tumour chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46: 5276-81.
2. Moolten FL, Wells JM. Curability of tumours bearing herpes thymidine kinase genes transferred by retroviral vectors. J Natl Cancer Inst 1990; 82: 297-300.
3. Ezzeddine ZD, Martuza RL, Platika D, Short MP, Malick A, Choi B, Breakefield XO. Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol 1991; 3: 608-14.
4. Takamiya Y, Short MP, Moolten FL, Fleet C, Mineta T, Breakefield XO, Martuza RL. An experimental model of retrovirus gene therapy for malignant brain tumours. J Neurosurg 1993; 79: 104-10.
5. Kato K, Yoshida J, Mizuno M, Sugita K, Emi N. Retroviral transfer of herpes simplex thymidine kinase gene into glioma cells causes targeting of gancyclovir cytotoxic effect. Neurol Med Chir 1994; 34: 339-44.
6. Nagy H, Panis Y, Fabre M, Perrin H, Klatzmann D, Houssin D. Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene. Surgery 1998; 123: 19-24.
7. DeAngelis LM. Brain tumours. New Engl J Med 2001; 344: 114-23.
8. Rainov NG, Kramm CM, Aboody-Guterman K, Chase M, Ueki K, Louis DN, Harsh GR et al. Retrovirus-mediated gene therapy of experimental brain neoplasms using the herpes simplex virus-thymidine kinase/ganciclovir paradigm. Cancer Gene Ther 1996; 3: 99-106.
9. Short MP, Choi BC, Lee JK, Malick A, Breakefield XO, Martuza RL. Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J Neurosci Res 1990; 27: 427-39.
10. Culver KW, Ram Z, Wallbridge S, Ishii H, Blaese RM. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumours. Science 1992; 256: 1550-2.
11. Joseph JM, Goddard MB, Mills J, Padrun V, Zurn A, Zielinski B, Favre J et al. Transplantation of encapsulated bovine chromaffin cells in the sheep subarachnoid space: a preclinical study for the treatment of cancer pain. Cell Transplant 1994; 3: 355-64.
12. Aebischer P, Tresco PA, Winn SR, Greene LA, Jaeger CB. Long-term cross-species brain transplantation of a polymer-encapsulated dopamine-secreting cell line. Exp Neurol 1991; 111: 269-75.
13. Aebischer P, Buchser E, Joseph JM, Favre J, de Tribolet N, Lysaght M, Rudnick S et al. Transplantation in humans of encapsulated xenogeneic cells without immunosuppression. A preliminary report. Transplantation 1994; 58: 1275-7.
14. Aebischer P, Goddard M, Signore AP, Timpson RL. Functional recovery in hemiparkinsonian primates transplanted with polymer-encapsulated PC12 cells. Exp Neurol 1994; 126: 151-8.
15. Tamiya T, Wei MX, Chase M, Ono Y, Lee F, Breakefield XO, Chiocca, EA. Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumours inoculated with retroviral vector producer cells. Gene Ther 1995; 2: 531-8.
16. Cepko C. Lineage analysis and immortalisation of neural cells via retrovirus vectors. In: A, A. Boulton, G. B. Backer and A. T. Campagnoni (eds). Neuromethods, vol. 16 Molecular Neurobiological Techniques. Clifton, NJ: Humana Press, Inc, 1989.
17. Freeman SM, Abboud CN, Whartenby KA, Packman CH, Koeplin DS, Moolten FL, Abraham GN. The 'bystander effect': tumour regression when a fraction of the tumour mass is genetically modified. Cancer Res 1993; 53: 5274-83.
18. Naus CC, Bechberger JF, Caveney S, Wilson JX. Expression of gap junction genes in astrocytes and C6 glioma cells. Neurosci Lett 1991; 126: 33-6.
19. Naus CC, Elisevich K, Zhu D, Belliveau DJ, Del Maestro RF. In vivo growth of C6 glioma cells transfected with connexin43 cDNA. Cancer Res 1992; 52: 4208-13.
20. Chen SH, Shine HD, Goodman JC, Grossman RG, Woo SL. Gene therapy for brain tumours: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA 1994; 91: 3054-7.
21. Kramm CM, Rainov NG, Sena-Esteves M, Barnett FH, Chase M, Herrlinger U, Pechan PA et al. Long-term survival in a rodent model of disseminated brain tumours by combined intrathecal delivery of herpes vectors and ganciclovir treatment. Hum Gene Ther 1996; 7: 1989-94.
22. Kramm CM, Chase M, Herrlinger U, Jacobs A, Pechan PA, Rainov NG, Sena-Esteves M et al. Therapeutic efficiency and safety of a second-generation replication-conditional HSVI vector for brain tumour gene therapy. Hum Gene Ther 1997; 8: 2057-68.
23. Palu G, Cavaggioni A, Calvi P, Franchin E, Pizzato M, Boschetto R, Parolin C et al. Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans. Gene Ther 1999; 6: 330-7.
24. Moriuchi S, Oligino T, Krisky D, Marconi P, Fink D, Cohen J, Glorioso JC. Enhanced tumour cell killing in the presence of ganciclovir by herpes simplex virus type I vector-directed coexpression of human tumour necrosis factor-alpha and herpes simplex virus thymidine kinase. Cancer Res 1998; 58: 5731-7.
25. Klatzmann D, Valery CA, Bensimon G, Marro B, Boyer O, Mokhtari K, Diquet B et al. A phase I/II study of herpes simplex virus type I thymidine kinase 'suicide' gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma. Hum Gene Ther 1998; 9: 2595-604.
26. Ram Z, Culver KW, Oshiro EM, Viola JJ, De Vroom HL, Otto E, Long Z et al. Therapy of malignant brain tumours by intratumoural implantation of retroviral vector-producing cells. Nat Med 1997; 3: 1354-61.
27. Rainov NG. A phase III clinical evaluation of herpes simplex virus type I thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther 2000; 11: 2389-401.
28. Singh S, Cunningham C, Buchanan A, Jolly DJ, Nemunaitis J. Toxicity assessment of intratumoural injection of the herpes simplex type I thymidine kinase gene delivered by retrovirus in patients with refractory cancer. Mol Ther 2001; 4: 157-60.
29. Sung MW, Yeh HC, Thung SN, Schwartz ME, Mandeli JP, Chen SH, Woo SL. Intratumoural adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: results of a phase I clinical trial. Mol Ther 2001; 4: 182-91.
30. Shalev M, Kadmon D, Teh BS, Butler EB, Aguilar-Cordova E, Thompson TC, Herman JR et al. Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer. J Urol 2000; 163: 1747-50.