Analysis of the apo(a) size polymorphism in Asian Indian populations: Association with Lp(a) concentration and coronary heart disease

Atherosclerosis

Volumn 169, Issue 1, 2003, Pages 121-130

  Geethanjali, F S ^a   Luthra, Kalpana ^a   Lingenhel, Arno ^a   Kanagasaba Pathy, A S ^b   Jacob, Jose ^b   Srivastava, Lalit M ^c   Vasisht, Suman ^c   Kraft, Hans Georg ^a   Utermann, Gerd ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b CHRISTIAN MEDICAL COLLEGE   (India)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Apolipoprotein(a); Association study; Coronary heart disease; Genetic architecture; Indian population; Lipoprotein(a); Polymorphism; Risk factor

Indexed keywords

APOLIPOPROTEIN A; LIPOPROTEIN A;

ADULT; ALLELE; ARTICLE; ASIAN; CONTROLLED STUDY; CORONARY RISK; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE LINKAGE GROUP; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INTERMETHOD COMPARISON; ISCHEMIC HEART DISEASE; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MORPHOLOGICAL TRAIT; POPULATION RESEARCH; PRIORITY JOURNAL;

EID: 0037968849     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(03)00143-6     Document Type: Article

References (35)

1. Murray C.J., Lopez A.D. Mortality by cause for eight regions of the world: global burden of disease study. Lancet. 349:1997;1269-1276.
2. Murray C.J., Lopez A.D. Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study. Lancet. 349:1997;1498-1504.
3. Vasisht S., Gulati R., Srivastava L.M., et al. Apolipoprotein(a) polymorphism and its association with plasma lipoprotein(a) levels: a North Indian study. Indian Heart J. 52:2000;165-170.
4. Christopher R., Kailasanatha K.M., Nagaraja D., Tripathi M. Case-control study of serum lipoprotein(a) and apolipoproteins A-I and B in stroke in the young. Acta Neurol. Scand. 94:1996;127-130.
5. Boerwinkle E., Leffert C.C., Lin J., Lackner C., Chiesa G., Hobbs H.H. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J. Clin. Invest. 90:1992;52-60.
6. Kraft H.G., Köchl S., Menzel H.J., Sandholzer C., Utermann G. The apolipoprotein(a) gene: a transcribed hypervariable locus controlling plasma lipoprotein(a) concentration. Hum. Genet. 90:1992;220-230.
7. Mooser V., Scheer D., Marcovina S.M., et al. The apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans. Am. J. Hum. Genet. 61:1997;402-417.
8. Scholz M., Kraft H.G., Lingenhel A., et al. Genetic control of lipoprotein(a) concentrations is different in Africans and Caucasians. Eur. J. Hum. Genet. 7:1999;169-178.
9. Utermann G. Genetic architecture and evolution of the lipoprotein(a) trait. Curr. Opin. Lipidol. 10:1999;133-141.
10. Utermann G. Lipoprotein(a). Scriver C.R., Beaudet A.L., Sly W.S., Valle D. The metabolic bases of inherited disease. 2001;2753-2787 McGrawHill, New York.
11. DeMeester C.A., Bu X., Gray R.J., Lusis A.J., Rotter J.I. Genetic variation in lipoprotein(a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein(a) gene locus. Am. J. Hum. Genet. 56:1995;287-293.
12. Kraft H.G., Lingenhel A., Kochl S., et al. Apolipoprotein(a) kringle IV repeat number predicts risk for coronary heart disease. Arterioscler. Thromb. Vasc. Biol. 16:1996;713-719.
13. Wild S.H., Fortmann S.P., Marcovina S.M. A prospective case-control study of lipoprotein(a) levels and apo(a) size and risk of coronary heart disease in Stanford Five-City Project participants. Arterioscler. Thromb. Vasc. Biol. 17:1997;239-245.
14. Linden T., Taddei-Peters W., Wilhelmsen L., et al. Serum lipids, lipoprotein(a) and apo(a) isoforms in patients with established coronary artery disease and their relation to disease and prognosis after coronary by-pass surgery. Atherosclerosis. 137:1998;175-186.
15. Klausen I.C., Sjol A., Hansen P.S., et al. Apolipoprotein(a) isoforms and coronary heart disease in men: a nested case-control study. Atherosclerosis. 132:1997;77-84.
16. Brazier L., Tiret L., Luc G., et al. Sequence polymorphisms in the apolipoprotein(a) gene and their association with lipoprotein(a) levels and myocardial infarction. The ECTIM study. Atherosclerosis. 144:1999;323.
17. Marcovina S.M., Albers J.J., Wijsman E., Zhang Z., Chapman N.H., Kennedy H. Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans. J. Lipid Res. 37:1996;2569-2585.
18. Paultre F., Pearson T.A., Weil H.F., et al. High levels of Lp(a) with a small apo(a) isoform are associated with coronary artery disease in African American and white men. Arterioscler. Thromb. Vasc. Biol. 20:2000;2619-2624.
19. Menzel H.-J., Dieplinger H., Lackner C., et al. Abetalipoproteinemia with an ApoB-100-lipoprotein(a) glycoprotein complex in plasma. Indication for an assembly defect. J. Biol. Chem. 265:1990;981-986.
20. Kraft H.G., Lingenhel A., Bader G., Kostner G.M., Utermann G. The relative electrophoretic mobility of apo(a) isoforms depends on the gel system: proposal of a nomenclature for apo(a) phenotypes. Atherosclerosis. 125:1996;53-61.
21. Kraft H.G., Lingenhel A., Pang R.W.C., et al. Frequency distributions of apolipoprotein(a) kringle IV repeat alleles and their effects on lipoprotein(a) levels in Caucasian, Asian, and African populations: the distribution of null alleles is non-random. Eur. J. Hum. Genet. 4:1996;74-87.
22. Pinto R.J. Risk factors for coronary heart disease in Asian Indians: clinical implications for prevention of coronary heart disease. Indian J. Med. Sci. 52:1998;49-54.
23. Enas E.A., Dhawan J., Petkar S. Coronary artery disease in Asian Indians: lessons learnt and the role of lipoprotein(a). Indian Heart J. 49:1997;25-34.
24. Dhawan J. Coronary heart disease risks in Asian Indians. Curr. Opin. Lipidol. 7:1996;196-198.
25. Hughes K., Aw T.C., Kuperan P., Choo M. Central obesity, insulin resistance, syndrome X, lipoprotein(a), and cardiovascular risk in Indians, Malays, and Chinese in Singapore. J. Epidemiol. Community Health. 51:1997;394-399.
26. Gazzaruso C., Geroldi D., Garzanti A., et al. Apolipoprotein(a) phenotypes as genetic markers of coronary atherosclerosis severity. Int. J. Cardiol. 64:1998;277-284.
27. Ogorelkova M., Kraft H.G., Ehnholm C., Utermann G. Single nucleotide polymorphisms in exons of the apo(a) kringles IV types 6 to 10 domain affect Lp(a) plasma concentrations and have different patterns in Africans and Caucasians. Hum. Mol. Genet. 10:2001;815-824.
28. Amemiya H., Arinami T., Kikuchi S., et al. Apolipoprotein(a) size and pentanucleotide repeat polymorphisms are associated with the degree of atherosclerosis in coronary heart disease. Atherosclerosis. 123:1996;181.
29. Gazzaruso C., Garzanti A., Buscaglia P., et al. Association between apolipoprotein(a) phenotypes and coronary heart disease at a young age. J. Am. Coll. Cardiol. 33:1999;157-163.
30. Sandholzer C., Saha N., Kark J.D., et al. Apo(a) isoforms predict risk for coronary heart disease: a study in six populations. Arterioscler. Thromb. 12:1992;1214-1226.
31. Hoogeveen R.C., Gambhir J.K., Gambhir D.S., et al. Evaluation of Lp[a] and other independent risk factors for CHD in Asian Indians and their USA counterparts. J. Lipid Res. 42:2001;631-638.
32. Bhatnagar D., Anand I.S., Durrington P.N., et al. Coronary risk factors in people from the Indian subcontinent living in West London and their siblings in India. Lancet. 345:1995;405-409.
33. Ober C., Abney M., McPeek M.S. The genetic dissection of complex traits in a founder population. Am. J. Hum. Genet. 69:2001;1068-1079.
34. Broeckel U., Hengstenberg C., Mayer B., et al. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat. Genet. 30:2002;210-214.
35. Moliterno D.J., Jokinen E.V., Miserez A.R., et al. No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African-Americans. Arterioscler. Thromb. 15:1995;850-855.