The relative electrophoretic mobility of apo(a) isoforms depends on the gel system: Proposal of a nomenclature for apo(a) phenotypes

Atherosclerosis

Volumn 125, Issue 1, 1996, Pages 53-61

  Kraft, H G ^a   Lingenhel, A ^a   Bader, G ^b   Kostner, G M ^c   Utermann, G ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITY OF GRAZ   (Austria)

Author keywords

Apo(a); PFGE; Phenotyping; Polymorphism; SDS electrophoresis

Indexed keywords

APOLIPOPROTEIN A; DNA;

ARTICLE; ATHEROSCLEROSIS; GENETIC POLYMORPHISM; GENOME; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS;

EID: 0030599041     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9150(96)05844-3     Document Type: Article

References (27)

1. [1] Utermann G, Menzel HJ, Kraft HG. Duba CH, Kemmler HG. Seitz C. Lp(a) glycoprotein phenotype. Inheritance and relation to Lp(a)-lipoprotein concentration in plasma. J Clin Invest 1987;80:458-465.
2. [2] Boerwinkle E, Menzel HJ, Kraft HG, Utermann G. Genetics of the quantitative Lp(a) lipoprotein trait. III. Contribution of Lp(a) glycoprotein phenotypes to normal lipid values. Hum Genet 1989;82:73-78.
3. [3] Boerwinkle E, Leffert CC, Lin J. Lackner C, Chiesa G, Hobbs HH. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest 1992:90:52-60.
4. [4] Kraft HG, Köchl S, Menzel HJ, Sandholzer C, Utermann G. The apolipoprotein(a) gene - a transcribed hyper-variable locus controlling plasma lipoprotein(a) concentration. Hum Genet 1992:90:220-230.
5. [5] Dahlen GH. Lp(a) lipoprotein in cardiovascular disease. Atherosclerosis 1994;108:111-126.
6. [6] Marcovina SM, Albers JJ. Jacobs DR, Perkins LL, Lewis CE. Howard BV. Savage P. Lipoprotein(a) concentrations and apolipoprotein(a) phenotypes in Caucasians and African Amerìcans - The CARDIA Study. Arterioscler Thromb 1993;13:1037-1045.
7. [7] Sandholzer C, Saha N, Kark JD, Rees A, Jaross W, Dieplinger H, Hoppichler F, Boerwinkle E, Utermann G. Apo(a) isoforms predict risk for coronary heart disease - a study in 6 populations. Arterioscler Thromb 1992;12:1214-1226.
8. [8] Pfaffinger D, Schuelke J, Kim C, Fless GM, Scanu AM. Relationship between apo(a) isoforms and Lp(a) density in subjects with different apo(a) phenotype: a study before and after a fatty meal. J Lipid Res 1991;32:679-683.
9. 664→leu mutation in the LDL receptor gene. J Clin Invest 1991;88:483-492.
10. [10] Gaubatz JW, Ghanem KI, Guevara JJr, Nava ML, Patsch W, Morrisett JD. Polymorphic forms of human apolipoprotein(a): inheritance and relationship of their molecular weights to plasma levels of lipoprotein(a). J Lipid Res 1990;31:603-613.
11. [11] Lackner C, Boerwinkle E, Leffert CC, Rahming T, Hobbs HH. Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis. J Clin Invest 1991;87:2153-2161.
12. [12] Lackner C, Cohen JC, Hobbs HH. Molecular definition of the extreme size polymorphism in apolipoprotein(a). Hum Mol Genet 1993;2:933-940.
13. [13] Gaw A, Boerwinkle E, Cohen JC, Hobbs HH. Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. J Clin Invest 1994;93:2526-2534.
14. [14] Marcovina SM, Zhang ZH, Gaur VP, Albers JJ. Identification of 34 apolipoprotein(a) isoforms: differential expression of apolipoprotein(a) alleles between American blacks and whites. Biochem Biophys Res Commun 1993;191:1192-1196.
15. [15] Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
16. [16] Neville DM. Molecular weight determination of protein dodecylsulfate complexes by gel electrophoresis in a discontinuous buffer system. J Biol Chem 1971;246:6328-6334.
17. [17] Kamboh MI. Ferrell RE, Kottke BA. Expressed hyper-variable polymorphism of apolipoprotein (a). Am J Hum Genet 1991;49:1063-1074.
18. [18] Towbin H, Staehlin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4354.
19. [19] Kraft HG, Dieplinger H, Hoye E, Utermann G. Lp (a) phenotyping by immunoblotting with polyclonal and monoclonal antibodies. Arteriosclerosis 1988;8:212-216.
20. [20] Kronenberg F, Lobentanz EM, König P, Utermann G, Dieplinger H. Effect of sample storage on the measurement of lipoprotein(a). apolipoproteins B and A-IV, total and high density lipoprotein cholesterol and triglycerides. J Lipid Res 1994;35:1318-1328.
21. [21] Kikuchi S, Nakagawa A, Kobayashi K, Li LM. Yanagi H. Arinami T, Kozu Y. Miyazaki R, Tsuchiya S. Hamaguchi H. High degree of genetic polymorphism in apolipoprotein(a) associated with plasma lipoprotein(a) levels in Japanese and Chinese populations. Hum Genet 1993;92:537-544.
22. [22] Weber K, Osborn M. In: Neurath H and Hill RL. (eds). The Proteins. New York: Academic Press, 1975;179-223.
23. [23] Kratzin H, Armstrong VW, Niehaus M, Hilschmann N, Seidel D. Structural relationship of an apolipoprotein(a) phenotype (570 kDa) to plasminogen: homologous kringle domains are linked by carbohydrate-rich regions. Biol Chem Hoppe-Seyler 1987;368:1533-1544.
24. [24] Budowle B. Giusti AM. Waye JS, Baechtel FS, Fourney RM, Adams DE, Presley LA. Deadman HA, Monson KL. Fixed-bin analysis for statistical evaluation of continuous distributions of allelic data from VNTR loci. for use in forensic comparisons. Am J Hum Genet 1991;48:841-855.
25. [25] Morrisett JD. Gaubatz JW. Knapp RD, Guevara JGJ. Structural properties of apo(a): a major apoprotein of human lipoprotein(a). In: Scanu A. (ed). Lipoprotein(a). San Diego: Academic Press Inc., 1990;53-74.
26. [26] VanderHoek YY, Wittekoek ME, Beisiegel U, Kastelein JJP, Koschinsky ML. The apolipoprotein(a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms. Hum Mol Genet 1993;2:361-366.
27. [27] Kraft HG, Haibach C, Lingenhel A, Brunner C. Trommsdorf M. Kronenberg F, Müller HJ, Utermann G. Sequence polymorphism in kringle IV-37 in linkage disequilibrium with the apolipoprotein(a) size polymorphism. Hum Genet 1995;95:275-282.