Role of β-lactam carboxyl group on binding of penicillins and cephalosporins to class C β-lactamases

Proteins: Structure, Function and Genetics

Volumn 51, Issue 3, 2003, Pages 442-452

  Fenollar Ferrer, Cristina ^a   Frau, Juan ^a   Donoso, Josefa ^a   Muñoz, Francisco ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

Molecular modeling structures; Mutated structure; Serine enzymes; lactam antibiotics; lactamase

Indexed keywords

BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CEFALOTIN; CEPHALOSPORIN DERIVATIVE; ENZYME; MUTANT PROTEIN; PENICILLIN DERIVATIVE; PENICILLIN G; SERINE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENTEROBACTER CLOACAE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BINDING SITES; BINDING, COMPETITIVE; CEPHALOSPORINASE; CEPHALOSPORINS; CEPHALOTHIN; ENTEROBACTER CLOACAE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PENICILLIN G; PENICILLINS; PROTEIN STRUCTURE, TERTIARY;

ENTEROBACTER; ENTEROBACTER CLOACAE;

EID: 0037963154     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10358     Document Type: Article

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