STAT signaling in ischemic heart: A role of STAT5A in ischemic preconditioning

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 285, Issue 2 54-2, 2003, Pages

  Yamaura, Genbu ^b   Turoczi, Tibor ^b   Yamamoto, Fumio ^b   Siddqui, M A Q ^b   Maulik, Nilanjana ^b   Das, Dipak K ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Akt; Apoptosis; Ischemia reperfusion; Janus kinase; Phosphatidylinositol 3 kinase; Src kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE INHIBITOR; STAT3 PROTEIN; STAT5 PROTEIN; STAT5A PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; ISCHEMIC HEART DISEASE; ISOLATED HEART; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0037962286     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00079.2003     Document Type: Article

References (27)

1. Blake RA, Garcia-Paramio P, Parker PJ, and Courtneidge SA. Src promotes PKCd degradation. Cell Growth Differ 10: 231-241, 1999.
2. Booz GW, Day JN, and Baker KM. Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure. J Mol Cell Cardiol 34: 1443-1453, 2002.
3. Cheng JJ, Chao YJ, and Wang DL. Cyclic strain activates redox-sensitive proline-rich tyrosine kinase 2 (PYK2) in endothelial cells. J Biol Chem 277: 48152-48157, 2002.
4. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, and Greenburg ME. Akt phosphorylation of Bad couples survival signals to the cell-intrinsic death machinary. Cell 91: 231-241, 1997.
5. Downward J. Mechanisms and consequences of activation of protein kinase B. Curr Opin Cell Biol 10: 262-267, 1998.
6. Hattori R, Maulik N, Otani H, Zhu L, Cordis G, Engelman RM, Siddiqui MAQ, and Das DK. Role of STAT3 in ischemic preconditioning. J Mol Cell Cardiol 33: 1929-1936, 2001.
7. Hattori R, Otani H, Uchiyama T, Imamura H, Cui J, Maulik N, Cordis GA, Zhu L, and Das DK. Src tyrosine kinase is the trigger but not the mediator of ischemic preconditioning. Am J Physiol Heart Circ Physiol 281: H1066-H1074, 2001.
8. Hou J, Schindler U, Menzel WJ, Ho TC, Brasseur M, and McNight SL. An interleukin 4-induced transcription factor: IL-4 Stat. Science 265: 1701-1706, 1994.
9. Kitakaze M, Node K, Asanuma H, Takashima S, Sakata Y, asakura M, Sanada S, Shinozaki Y, Mori H, Kuzuya T, and Hori M. Protein tyrosine kinase is not involved in the infarct size-limiting effect of ischemic preconditioning in canine hearts. Circ Res 87: 303-308, 2000.
10. Mascareno E, El-Shafei M, Maulik N, Sato M, Guo Y, Das DK, and Siddiqui MAQ. JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion. Circulation 104: 325-329, 2001.
11. Maulik N, Engelman RM, Flack JE, Rousou JA, Deaton D, and Das DK. Ischemic preconditioning reduces apoptosis by upregulating anti-death gene bcl-2. Circulation 100: II369-II375, 1999.
12. Maulik N, Sasaki H, Addya S, and Das DK. Regulation of cardiomyocyte apoptosis by redox-sensitive transcription factors. FEBS Lett 485: 7-12, 2000.
13. Miki T, Miura T, Tsuchida A, Nakano A, Hasegawa T, Fukuma T, and Shimamoto K. Cardioprotective mechanism of ischemic preconditioning is impaired by postinfarct ventricular remodeling through angiotensin II type 1 receptor activation. Circulation 102: 458-463, 2000.
14. Omura T, Yoshiyama M, Ishikura F, Kobayashi H, Takeuchi K, Beppu S, and Yoshikawa J. Myocardial ischemia activates the JAK-STAT pathway through angiotensin II signaling in in vivo myocardium of rats. J Mol Cell Cardiol 33: 307-316, 2001.
15. Ping P, Zhang J, Zheng YT, Li RCX, Dawn B, Tang XL, Takano H, Balafanova Z, and Bolli R. Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in consious rabbits. Circ Res 85: 542-550, 1999.
16. Ray PS, Martin JL, Swanson EA, Otani H, Dillmann WH, and Das DK. Transgene overexpression of aB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion. FASEB J 15: 393-402, 2001.
17. Sato M, Cordis GA, Maulik N, and Das DK. SAPKs regulation of ischemic preconditioning. Am J Physiol Heart Circ Physiol 279: H901-H907, 2000.
18. Sato M, Engelman RM, Otani H, Maulik N, Rousou JA, Flack JE, Deaton DW III, and Das DK. Myocardial protection by preconditioning of heart with losartan, an angiotensin II type 1-receptor blocker: implication of bradykinin-dependent and bradykinin-independent mechanisms. Circulation 102, Suppl 3: III346-III351, 2000.
19. Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, and Akira S. Essential role of STAT6 in IL-4 signaling. Nature 380: 627-630, 1996.
20. Timokhina I, Kissel H, Stella G, and Besmer P. Signaling through PI-3-kinase and Src kinase pathways: an essential role for Rac1 and Jnk activation in mast cell proliferation. EMBO J 17: 6250-6262, 1998.
21. Tong H, Chen W, Steenbergen C, and Murphy E. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res 87: 309-315, 2000.
22. Williams JG. STAT signaling in cell proliferation and in development. Curr Opin Genet Dev 10: 503-507, 2000.
23. Valdembri D, Serini G, Vacca A, Ribatti D, and Bussolino F. In vivo activation of JAK2/STAT-3 pathway during angiogenesis induced by GM-CSF. FASEB J 16: 225-227, 2002.
24. Xuan YT, Guo Y, Han H, Zhu Y, and Bolli R. An essential role of the JAK-STAT pathway in ischemic preconditioning. Proc Natl Acad Sci USA 98: 9050-9055, 2001.
25. Yoshida T, Maulik N, Ho YS, Alam J, and Das DK. Hmox-1 constitutes an adaptive response to effect antioxidant cardioprotection: a study with transgenic mice heterozygous for targeted disruption of the heme oxygenase-1 gene. Circulation 103: 1695-1701, 2001.
26. Yu-Lee LY. Prolactin modulation of immune and inflammatory responses. Recent Prog Horm Res 57: 435-455, 2002.
27. Zeng ZZ, Yellaturu CR, Neeli I, and Rao GN. 5(S)-hydroxy-eicosatetraenoic acid stimulates DNA synthesis in human mi.crovascular endothelial cells via activation of Jak/STAT and phosphatidylinositol 3-kinase/Akt signaling, leading to induction of expression of basic fibroblast growth factor 2. J Biol Chem 277: 41213-41219, 2002.