CD14-dependent clearance of apoptotic cells by human macrophages: The role of phosphatidylserine

Cell Death and Differentiation

Volumn 10, Issue 3, 2003, Pages 371-382

  Devitt, A ^a   Pierce, S ^b   Oldreive, C ^a   Shingler, W H ^a   Gregory, Chris D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Apoptosis; CD14; Inflammation; Monocytes macrophages; Phagocytosis; Phosphatidylserine

Indexed keywords

CD14 ANTIGEN; LIPOSOME; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHATIDYLSERINE RECEPTOR; PHOSPHOLIPID; RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; CELL INTERACTION; CELL LABELING; CELL SPECIFICITY; CELL STRUCTURE; CLEARANCE; CONTROLLED STUDY; ERYTHROCYTE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MONOCYTE; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REVIEW;

ANNEXIN A5; ANTIGENS, CD14; APOPTOSIS; CELL LINE; CELLS, CULTURED; CYCLOHEXIMIDE; ERYTHROCYTES; FLOW CYTOMETRY; HUMANS; LEUKOCYTES; LIGANDS; LIPID METABOLISM; LIPOSOMES; MACROPHAGES; MONOCYTES; NEUTROPHILS; PHAGOCYTOSIS; PHOSPHATIDYLSERINES; PROTEIN BINDING; PROTEIN SYNTHESIS INHIBITORS; RECOMBINANT PROTEINS; TIME FACTORS; ULTRAVIOLET RAYS;

EID: 0037959621     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401168     Document Type: Review

References (52)

1. Savill J and Fadok V (2000) Corpse clearance defines the meaning of cell death. Nature 407: 784-788
2. Fadok VA, Bratton DL and Henson PM (2001) Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J. Clin. Invest. 108: 957-962
3. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL and Henson PM (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148: 2207-2216
4. Verhoven B, Schlegel RA and Williamson P (1995) Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes. J. Exp. Med. 182: 1597-1601
5. Fadok VA, de Cathelineau A, Daleke DL, Henson PM and Bratton DL (2001) Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts. J. Biol. Chem. 276: 1071-1077
6. Duvall E, Wyllie AH and Morris RG (1985) Macrophage recognition of cells undergoing programmed cell death (apoptosis). Immunology 56: 351-358
7. Dini L, Autuori F, Lentini A, Oliverio S and Piacentini M (1992) The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptor. FEBS Lett. 296: 174-178
8. Moffatt OD, Devitt A, Bell ED, Simmons DL and Gregory CD (1999) Macrophage recognition of ICAM-3 on apoptotic leukocytes. J. Immunol. 162: 6800-6810
9. Brown S, Heinisch I, Ross E, Shaw K, Buckley CD and Savill J (2002) Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment. Nature 418: 200-203
10. Devitt A, Moffatt OD, Raykundalia C, Capra JD, Simmons DL and Gregory CD (1998) Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature 392: 505-509
11. Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RAB and Henson PM (2000) A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 405: 85-90
12. Savill J, Dransfield I, Hogg N and Haslett C (1990) Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 343: 170-173
13. Savill J, Hogg N, Ren Y and Haslett C (1992) Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J. Clin. Invest. 90: 1513-1522
14. Ren Y, Silverstein RL, Allen J and Savill J (1995) CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis. J. Exp. Med. 181: 1857-1862
15. Platt N, Suzuki H, Kurihara Y, Kodama T and Gordon S (1996) Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. Proc. Natl. Acad. Sci. USA 93: 12456-12460
16. Luciani M-F and Chimini G (1996) The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death. EMBO J. 15: 226-235
17. Hamon Y, Broccardo C, Chambenoit O, Luciani MF, Toti F, Chaslin S, Freyssinet JM, Devaux PF, McNeish J, Marguet D and Chimini G (2000) ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat. Cell Biol. 2: 399-406
18. Scott RS, McMahon EJ, Pop SM, Reap EA, Caricchio R, Cohen PL, Earp HS and Matsushima GK (2001) Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411: 207-211
19. Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA and Henson PM (2001) C1q and mannose-binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J. Exp. Med. 194: 781-795
20. Botto M, DellAgnola C, Bygrave AE, Thompson EM, Cook HT, Petry F, Loos M, Pandolfi PP and Walport MJ (1998) Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet. 19: 56-59
21. Gershov D, Kim S, Brot N and Elkon KB (2000) C-reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J. Exp. Med. 192: 1353-1363
22. Schagat TL, Wofford JA and Wright JR (2001) Surfactant protein A enhances alveolar macrophage phagocytosis of apoptotic neutrophils. J. Immunol. 166: 2727-2733
23. Hoffmann PR, deCathelineau AM, Ogden CA, Leverrier Y, Bratton DL, Daleke DL, Ridley AJ, Fadok VA and Henson PM (2001) Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells. J. Cell Biol. 155: 649-659
24. Flora PK and Gregory CD (1994) Recognition of apoptotic cells by human macrophages - inhibition by a monocyte/macrophage-specific monoclonal antibody. Eur. J. Immunol. 24: 2625-2632
25. Schlegel RA, Krahling S, Callahan MK and Williamson P (1999) CD14 is a component of multiple recognition systems used by macrophages to phagocytose apoptotic lymphocytes. Cell Death Differ. 6: 583-592
26. Yu B, Hailman E and Wright SD (1997) Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids. J. Clin. Invest. 99: 315-324
27. Wang PY, Kitchens RL and Munford RS (1998) Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide. J. Biol. Chem. 273: 24309-24313
28. Wang PY and Munford RS (1999) CD14-dependent internalization and metabolism of extracellular phosphatidylinositol by monocytes. J. Biol. Chem. 274: 23235-23241
29. Sugiyama T and Wright SD (2001) Soluble CD14 mediates efflux of phospholipids from cells. J. Immunol. 166: 826-831
30. Haslett C, Guthrie LA, Kopaniak MM, Johnston RB and Henson PM (1985) Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide. Am. J. Pathol. 119: 101-110
31. Gregory CD, Rowe M and Rickinson AB (1990) Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line. J. General Virol. 71: 1481-1495
32. Visvader JE, Elefanty AG, Strasser A and Adams JM (1992) GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line. EMBO J. 11: 4557-4564
33. Fadok VA, Warner ML, Bratton DL and Henson PM (1998) CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha(v)beta(3)). J. Immunol. 161: 6250-6257
34. Schlegel RA and Rechsteiner MC (1978) Red cell-mediated microinjection of macromolecules into mammalian cells. Methods Cell Biol. 20: 341-354
35. Fadok VA, Savill JS, Haslett C, Bratton DL, Doherty DE, Campbell PA and Henson PM (1992) Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J. Immunol. 149: 4029-4035
36. Gregory CD and Devitt A (1999) CD14 and apoptosis. Apoptosis 4: 11-20
37. Dziarski R, Ulmer AJ and Gupta D (2000) Interactions of CD14 with components of Gram-positive bacteria. In CD14 in the Inflammatory Response pp. 83-107 RS Jack (ed) Karger
38. Kitchens RL (2000) Role of CD14 in cellular recognition of bacterial lipopolysaccharides. In CD14 in the Inflammatory Response pp. 61-82 RS Jack (ed) Karger
39. Janicke RU, Sprengart ML, Wati MR and Porter AG (1998) Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 273: 9357-9360
40. Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kagi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW and Mak TW (1998) Essential contribution of caspase 3 CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 12: 806-819
41. Zheng TS, Schlosser SF, Dao T, Hingorani R, Crispe IN, Boyer JL and Flavell RA (1998) Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc. Natl. Acad. Sci. USA 95: 13618-13623
42. Turner C, Devitt A, Parker K, MacFarlane M, Giuliano M, Cohen GM and Gregory CD (2002) Macrophage-mediated clearance of cells undergoing caspase-3-independent death. Submitted
43. Krahling S, Callahan MK, Williamson P and Schlegel RA (1999) Exposure of phosphatidylserine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages. Cell Death Differ. 6: 183-189
44. Shiratsuchi A, Osada S, Kanazawa S and Nakanishi Y (1998) Essential role of phosphatidylserine externalization in apoptosing cell phagocytosis by macrophages. Biochem. Biophys. Res. Comm. 246: 549-555
45. Verhoven B, Krahling S, Schlegel RA and Williamson P (1999) Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes. Cell Death Differ. 6: 262-270
46. Kagan VE, Gleiss B, Tyurina YY, Tyurin VA, Elenstrom-Magnusson C, Liu SX, Serinkhan FB, Arroyo A, Chandra J, Orrenius S and Fadeel B (2002) A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis. J. Immunol. 169: 487-499
47. Dillon SR, Mancini M, Rosen A and Schlissel MS (2000) Annexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activation. J. Immunol. 164: 1322-1332
48. Dini L, Carla EC, De Luca M, Faraldi G and Tagliafierro G (1999) Phagocytosis of apoptotic cells: liver recognition and molecular mechanisms. Italian J. Zool. 66: 317-322
49. Watanabe Y, Shiratsuchi A, Shimizu K, Takizawa T and Nakanishi Y (2002) Role of phosphatidylserine exposure and sugar chain desialylation at the surface of influenza virus-infected cells in efficient phagocytosis by macrophages. J. Biol. Chem. 277: 18222-18228
50. Fujii C, Shiratsuchi A, Manaka J, Yonehara S and Nakanishi Y (2001) Difference in the way of macrophage recognition of target cells depending on their apoptotic states. Cell Death Differ. 8: 1113-1122
51. Anderson HA, Englert R, Gursel I and Shacter E (2002) Oxidative stress inhibits the phagocytosis of apoptotic cells that have externalized phosphatidylserine. Cell Death Differ. 9: 616-625
52. Ren Y, Stuart L, Lindberg FP, Rosenkranz AR, Chen YM, Mayadas TN and Savill J (2001) Non-phlogistic clearance of late apoptotic neutrophils by macrophages: efficient phagocytosis independent of beta(2) integrins. J. Immunol. 166: 4743-4750