Aging and asthma: Pathophysiological mechanisms

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 58, Issue 3, 2003, Pages 165-175

  Vignola, A M ^a,b   Scichilone, N ^a   Bousquet, J ^c   Bonsignore, G ^a,b   Bellia, V ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b CNR   (Italy)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ASTHMA; DISEASE COURSE; HUMAN; HYPERSENSITIVITY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LUNG FUNCTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

AGING; ASTHMA; HUMANS; IMMUNE SYSTEM; IMMUNITY; LUNG;

EID: 0037957315     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1398-9995.2003.02163.x     Document Type: Review

References (116)

1. BRAMAN SS. Asthma in the elderly patient. Clin Chest Med 1993;14:413-422.
2. ISOAHO R, PUOLIJOKI H, HUHTI E, KIVELA SL, TALA E. Prevalence of asthma in elderly Finns. J Clin Epidemiol 1994;47:1109-1118.
3. NEJJARI C, TESSIER JF, LETENNEUR L, DARTIGUES JF, BARBERGER-GATEAU P, SALAMON R. Prevalence of self-reported asthma symptoms in a French elderly sample. Respir Med 1996;90:401-408.
4. DYER CA, HILL SL, STOCKLEY RA, SINCLAIR AJ. Quality of life in elderly subjects with a diagnostic label of asthma from general practice registers. Eur Respir J 1999;14:39-45.
5. DOW L, FOWLER L, PHELPS L, et al. Prevalence of untreated asthma in a population sample of 6000 older adults in Bristol, UK. Thorax 2001;56:472-476.
6. PARAMESWARAN K, HILDRETH AJ, CHADHA D, KEANEY NP, TAYLOR IK, BANSAL SK. Asthma in the elderly: underperceived, underdiagnosed and undertreated; a community survey. Respir Med 1998;92:573-577.
7. ENRIGHT PL, MCCLELLAND RL, NEWMAN AB, GOTTLIEB DJ, LEBOWITZ MD. Underdiagnosis and undertreatment of asthma in the elderly. Cardiovascular Health Study Research Group (see Comments). Chest 1999;116:603-613.
8. CYDULKA RK, MCFADDEN E JR, EMERMAN CL, SIVINSKI LD, PISANELLI W, RIMM AA. Patterns of hospitalization in elderly patients with asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997;156:1807-1812.
9. DANTZER C, TESSIER JF, NEJJARI C, BARBERGER-GATEAU P, DARTIGUES JF. Mortality of elderly subjects with self-reported asthma in a French cohort, 1991-96. Eur J Epidemiol 2001;17:57-63.
10. ENRIGHT PL, WARD BJ, TRACY RP, LASSER EC. Asthma and its association with cardiovascular disease in the elderly. The Cardiovascular Health Study Research Group. J Asthma 1996;33:45-53.
11. BEN-NOUN L. Characteristics of comorbidity in adult asthma. Public Health Rev 2001;29:49-61.
12. BRAMAN SS. Drug treatment of asthma in the elderly. Drugs 1996;51:415-423.
13. THURLBECK WM. Morphology of the Aging Lung. New York: Raven Press 1991.
14. REED CE. The natural history of asthma in adults. The problem of irreversibility. J Allergy Clin Immunol 1999;103:539-547.
15. CASSINO C, BERGER KI, GOLDRING RM, et al. Duration of asthma and physiologic outcomes in elderly nonsmokers [In Process Citation]. Am J Respir Crit Care Med 2000;162:1423-1428.
16. BURROWS B, HALONEN M, LEBOWITZ MD, KNUDSON RJ, BARBEE RA. The relationship of serum immunoglobulin E, allergy skin tests, and smoking to respiratory disorders. J Allergy Clin Immunol 1982;70:199-204.
17. SCHACHTER EN, DOYLE CA, BECK GJ. A prospective study of asthma in a rural community. Chest 1984;85:623-630.
18. PEAT JK, WOOLCOCK AJ, CULLEN K. Rate of decline of lung function in subjects with asthma. Eur J Respir Dis 1987;70:171-179.
19. VAN-SCHAYCK CP, DOMPELING E, VAN-HERWAARDEN CL, WEVER AM, VAN-WEEL C. Interacting effects of atopy and bronchial hyperresponsiveness on the annual decline in lung function and the exacerbation rate in asthma. Am Rev Respir Dis 1991;144:1297-1301.
20. ALMIND M, VISKUM K, EVALD T, DIRKSEN A, KOK-JENSEN A. A seven-year follow-up study of 343 adults with bronchial asthma. Dan Med Bull 1992;39:561-565.
21. ULRIK CS, BACKER V, DIRKSEN A. A 10-year follow-up of 180 adults with bronchial asthma: factors important for the decline in lung function. Thorax 1992;47:14-18.
22. ASPINALL R. Longevity and the immune response. Biogerontology 2000;1:273-278.
23. YUNG RL. Changes in immune function with age. Rheum Dis Clin North Am 2000;26:455-473.
24. CASTLE SC. Clinical relevance of age-related immune dysfunction. Clin Infect Dis 2000;31:578-585.
25. LEWIS VM, TWOMEY JJ, BEALMEAR P, GOLDSTEIN G, GOOD RA. Age, thymic involution, and circulating thymic hormone activity. J Clin Endocrinol Metab 1978;47:145-150.
26. HAYNES BF, SEMPOWSKI GD, WELLS AF, HALE LP. The human thymus during aging. Immunol Res 2000;22:253-261.
27. LIGTHART GJ, SCHUIT HR, HIJMANS W. Subpopulations of mononuclear cells in ageing. Expansion of the null cell compartment and decrease in the number of T and B cells in human blood. Immunology 1985;55:15-21.
28. O'LEARY JJ, HALLGREN HM. Expression of T cell associated surface antigens on lymphocytes of persons of advanced age. Prog Clin Biol Res 1983;133:89-93.
29. GOODWIN JS, SEARLES RP, TUNG KS. Immunological responses of healthy elderly population. Clin Exp Immunol 1982;48:403-410.
30. WALDORF DS, WILLKENS RF, DECKER JL. Impaired delayed hypersensitivity in an aging population. Association with antinuclear reactivity and rheumatoid factor. JAMA 1968;203:831-834.
31. + T cell functions with aging. J Immunol 1997;159:3453-3459.
32. IDE K, HAYAKAWA H, YAGI T, et al. Decreased expression of Th2 type cytokine mRNA contributes to the lack of allergic bronchial inflammation in aged rats. J Immunol 1999;163:396-402.
33. WADA T, TOMA T, SHIMURA S, et al. Age-dependent increase of IgE-binding and Fc epsilon RI expression on circulating basophils in children. Pediatr Res 1999;46:603-607.
34. SPARROW D, O'CONNOR GT, ROSNER B, WEISS ST. Predictors of longitudinal change in methacholine airway responsiveness among middle-aged and older men: the Normative Aging Study. Am J Respir Crit Care Med 1994;149:376-381.
35. KHANNA KV, MARKHAM RB. A perspective on cellular immunity in the elderly. Clin Infect Dis 1999;28:710-713.
36. ANTONACI S, JIRILLO E, VENTURA MT, GAROFALO AR, BONOMO L. Non-specific immunity in aging: deficiency of monocyte and polymorphonuclear cell-mediated functions. Mech Ageing Dev 1984;24:367-375.
37. LYONS CR, BALL EJ, TOEWS GB, WEISSLER JC, STASTNY P, LIPSCOMB MF. Inability of human alveolar macrophages to stimulate resting T cells correlates with decreased antigen-specific T cell-macrophage binding. J Immunol 1986;137:1173-1180.
38. LIPSCOMB MF, LYONS CR. NUNEZ G, et al. Human alveolar macrophages: HLA-DR-positive macrophages that are poor stimulators of a primary mixed leukocyte reaction. J Immunol 1986;136:497-504.
39. ABE T, MORIMOTO C, TOGUCHI T, KIYOTAKI M, HOMMA M. The cellular basis of impaired T lymphocyte functions in the elderly. J Am Geriatr Soc 1980;28:265-271.
40. MALECH HL, GALLIN JI. Current concepts: immunology. Neutrophils in human diseases. N Engl J Med 1987;317:687-694.
41. FANTONE JC, WARD PA. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am J Pathol 1982;107:395-418.
42. LLOYD AR, OPPENHEIM JJ. Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response. Immunol Today 1992;13:169-172.
43. LONKY SA, MCCARREN J. Neutrophil enzymes in the lung: regulation of neutrophil elastase. Am Rev Respir Dis 1983;127:S9-S15.
44. JANOFF A. Elastase in tissue injury. Ann Rev Med 1985;36:207-216.
45. NAKAMURA H, YOSHIMURA K, MCELVANEY NG, CRYSTAL RG. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Invest 1992;89:1478-1484.
46. CORBERAND J, NGYEN F, LAHARRAGUE P, et al. Polymorphonuclear functions and aging in humans. J Am Geriatr Soc 1981;29:391-397.
47. LORD JM, BUTCHER S, KILLAMPALI V, LASCELLES D, SALMON M. Neutrophil ageing and immunesenescence. Mech Ageing Dev 2001;122:1521-1535.
48. BUTCHER SK, CHAHAL H, NAYAK L, et al. Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leukoc Biol 2001;70:881-886.
49. EMANUELLI G, LANZIO M, ANFOSSI T, ROMANO S, ANFOSSI G, CALCAMUGGI G. Influence of age on polymorphonuclear leukocytes in vitro: phagocytic activity in healthy human subjects. Gerontology 1986;32:308-316.
50. MEYER KC, ROSENTHAL NS, SOERGEL P, PETERSON K. Neutrophils and low-grade inflammation in the seemingly normal human lung. Mech Ageing Dev 1998;104:169-181.
51. MEYER KC, ERSHLER W, ROSENTHAL NS, LUX G, PETERSON K. Immune dysregulation in the aging human lung. Am J Respir Int Care Med 1996;153:1072-1079.
52. YAGI T, SATO A, HAYAKAWA H, IDE K. Failure of aged rats to accumulate eosinophils in allergic inflammation of the airway. J Allergy Clin Immunol 1997;99:38-47.
53. PUCHELLE E, ZAHM JM, BERTRAND A. Influence of age on bronchial mucociliary transport. Scand J Respir Dis 1979;60:307-313.
54. GINALDI L, LORETO MF, CORSI MP, MODESTI M, DE MARTINIS M. Immunosenescence and infectious diseases. Microbes Infect 2001;3:851-857.
55. EFFROS RB. Ageing and the immune system. Novartis Found Symp 2001;235:130-139.
56. MEYER KC. The role of immunity in susceptibility to respiratory infection in the aging lung. Respir Physiol 2001;128:23-31.
57. BRUUNSGAARD H, PEDERSEN M, PEDERSEN BK. Aging and proinflammatory cytokines. Curr Opin Hematol 2001;8:131-136.
58. JOAQUIN AM, GOLLAPUDI S. Functional decline in aging and disease: a role for apoptosis. J Am Geriatr Soc 2001;49:1234-1240.
59. JATAKANON A, UASUF C, MAZIAK W, LIM S, CHUNG KF, BARNES PJ. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Medical 1999;160:1532-1539.
60. WENZEL SE, SZEFLER SJ, LEUNG DY, SLOAN SI, REX MD, MARTIN RJ. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 1997;156:737-743.
61. WENZEL SE, SCHWARTZ LB, LANGMACK EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999;160:1001-1008.
62. LEE KH, CHIN NK, LIM TK. Asthma in the elderly - a more severe disease. Singapore Med J 2000;41:579-581.
63. QUADRELLI SA, RONCORONI A. Features of asthma in the elderly. J Asthma 2001;38:377-389.
64. WEINER P, MAGADLE R, WAIZMAN J, WEINER M, RABNER M, ZAMIR D. Characteristics of asthma in the elderly. Eur Respir J 1998;12:564-568.
65. JOHANSSON SG, HOURIHANE JO, BOUSQUET J, et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 2001;56:813-824.
66. SMITH DM. The effect of respiratory disease on working life. J R Soc Med 1988;81:258-260.
67. HANNEUSE Y, DELESPESSE G, HUDSON D, DE HALLEUX F, JACQUES JM. Influence of ageing on IgE-mediated reactions in allergic patients. Clin Allergy 1978;8:165-174.
68. BARBEE RA, BROWN WG, KALTENBORN W, HALONEN M. Allergen skin-test reactivity in a community population sample: correlation with age, histamine skin reactions and total serum immunoglobulin E. J Allergy Clin Immunol 1981;68:15-19.
69. STOY PJ, ROITMAN-JOHNSON B, WALSH G, et al. Aging and serum immunoglobulin E levels, immediate skin tests, RAST. J Allergy Clin Immunol 1981;68:421-426.
70. GILLIS S, KOZAK R, DURANTE M, WEKSLER ME. Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J Clin Invest 1981;67:937-942.
71. FONG TC, MAKINODAN T. In situ hybridization analysis of the age-associated decline in IL-2 mRNA expressing murine T cells. Cell Immunol 1989;118:199-207.
72. HOBBS MV, WEIGLE WO, NOONAN DJ, et al. Patterns of cytokine gene expression by CD4+ T cells from young and old mice. J Immunol 1993;150:3602-3614.
73. ERNST DN, WEIGLE WO, HOBBS MV. Aging and lymphokine production by T cell subsets. Stem Cells 1993;11:487-498.
74. SMITH P, DUNNE DW, FALLON PG. Defective in vivo induction of functional type 2 cytokine responses in aged mice. Eur J Immunol 2001;31:1495-1502.
75. SKASSA-BROCIEK W, MANDERSCHEID JC, MICHEL FB, BOUSQUET J. Skin test reactivity to histamine from infancy to old age. J Allergy Clin Immunol 1987;80:711-716.
76. HUSS K, NAUMANN PL, MASON PJ, et al. Asthma severity, atopic status, allergen exposure and quality of life in elderly persons. Ann Allergy Asthma Immunol 2001;86:524-530.
77. VAN-SCHAYCK CP, FOLGERING H, DEN-OTTER JJ, TIRIMANNA P, VAN-WEEL C. Does the continuous use of bronchodilators mask the progression of asthma or chronic bronchitis? Fam Pract 1992;9:397-404.
78. BRAMAN SS, KAEMMERLEN JT, DAVIS SM. Asthma in the elderly. A comparison between patients with recently acquired and long-standing disease. Am Rev Respir Dis 1991;143:336-340.
79. BURROWS B, BARBEE RA, CLINE MG, KNUDSON RJ, LEBOWITZ MD. Characteristics of asthma among elderly adults in a sample of the general population. Chest 1991;100:935-942.
80. CONNOLLY MJ, CROWLEY JJ, CHARAN NB, NIELSON CP, VESTAL RE. Impaired bronchodilator response to albuterol in healthy elderly men and women. Chest 1995;108:401-406.
81. KELLY WJ, HUDSON I, RAVEN J, PHELAN PD, PAIN MC, OLINSKY A. Childhood asthma and adult lung function. Am Rev Respir Dis 1988;138:26-30.
82. MAYS PK, MCANULTY RJ, LAURENT GJ. Age-related changes in lung collagen metabolism. A role for degradation in regulating lung collagen production. Am Rev Respir Dis 1989;140:410-416.
83. MAYS PK, MCANULTY RJ, LAURENT GJ. Age-related changes in rates of protein synthesis and degradation in rat tissues. Mech Ageing Dev 1991;59:229-241.
84. GERRITSEN J, KOETER GH, POSTMA DS, SCHOUTEN JP, KNOL K. Prognosis of asthma from childhood to adulthood. Am Rev Respir Dis 1989;140:1325-1330.
85. THE CHILDHOOD ASTHMA MANAGEMENT PROGRAM RESEARCH GROUP. Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group (see Comments). N Engl J Med 2000;343:1054-1063.
86. LANGE P, PARNER J, VESTBO J, SCHNOHR P, JENSEN G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998;339:1194-1200.
87. MITSUNOBU F, MIFUNE T, ASHIDA K, et al. Influence of age and disease severity on high resolution CT lung densitometry in asthma. Thorax 2001;56:851-856.
88. 1 decline in older adults: the Normative Aging Study. J Allergy Clin Immunol 1998;101:720-725.
89. POLKEY MI, HARRIS ML, HUGHES PD. The contractile properties of the elderly human diaphragm. Am J Respir Crit Care Med 1997;155:1560-1564.
90. TOLEP K, SK. Effect of aging on respiratory skeletal muscle. Clin Chest Med 1993;14:363-378.
91. ENRIGHT PL, KRONMAL RA, MANOLIO TA, SCHENKER MB, HYATT RE. Respiratory muscle strength in the elderly: correlates and reference values. Am J Respir Crit Care Med 1994;149:430-438.
92. CRAPO RO. The aging lung. In: MAHLER, DA, editor. Pulmonary Disease in the Elderly Patient. New York: Marcel Dekker 1993;63:1-21.
93. VERBEKEN EK, CAUBERGHS M, MERTENS I, CLEMENT J, LAUWERYNS JM, VAN DE WOESTIJNE KP. The senile lung. Comparison with normal and emphysematous lungs. Chest 1992;101:793-799.
94. JANSSENS JP, PACHE JC, NICOD LP. Physiological changes in respiratory function associated with ageing. Eur Respir J 1999;13:197-205.
95. MURRAY JF. Aging. In: MURRAY, JF, editor. The Normal Lung. Philadelphia, PA: WB saunders 1986, 339-360.
96. LANG M, FIAUX G, GILLOOLY M, STEWART J, HULMES D, LAMB D. Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs. Thorax 1994;49:319-326.
97. WAGNER P, LAVARUSO R, UHL R, WEST J. Continuous distribution of ventilation-perfusion ratios in normal subjects breathing air and 100 percent O2. J Clin Invest 1974;54:54-68.
98. THURLBECK W, ANGUS G. Growth and aging in the normal human lung. Chest 1975;67:3S-7S.
99. DOW L, COGGON D, OSMOND G, HOLGATE ST. A population survey of respiratory symptoms in the elderly. Eur Respir J 1991;4:267-272.
100. BELLIA V, PISTELLI R, CATALANO F, et al. Quality control of spirometry in the elderly. The SARA Study. Am J Respir Crit Care Med 2000;161:1094-1100.
101. SPARROW D, O'CONNOR GT, ROSNER B, SEGAL MR, WEISS ST. The influence of age and level of pulmonary function on nonspecific airway responsiveness. The Normative Aging Study. Am Rev Respir Dis 1991;143:978-982.
102. HOPP RJ, BEWTRA A, NAIR NM. The effect of age on methacholine response. J Allergy Clin Immunol 1985;76:609-613.
103. BURNEY PGJ, BRITTON JR, CHINN S. Descriptive epidemiology of bronchial reactivity in an adult population: results from a community study. Thorax 1987;42:38-44.
104. DAVIS PB, BYARD PJ. Relationship among airway reactivity, pupillary alpha adrenergic and cholinergic responsiveness, and age. J Appl Physiol 1988;65:200-206.
105. ULLAH MI, NEWMAN GB, SAUNDERS KB. Influence of age on response to ipatropium and salbutamol in asthma. Thorax 1981;36:523-527.
106. VAN SHAYCK CP, DOMPELING E, VAN ERWAARDEN CLA. Interacting effects of atopy and bronchial hyperresponsiveness on the annual decline in lung function and the exacerbation rate in asthma. Am Rev Respir Dis 1991;144:1297-1302.
107. BELLIA V, CIBELLA F, CUTTITTA G, et al. Effect of age upon airway obstruction and reversibility in adult patients with asthma. Chest 1998;114:1336-1342.
108. VESTAL R, WOOD A, SHAND D. Reduced beta-adrenoceptor sensitivity in the elderly. Clin Pharmacol Ther 1979;26:181-186.
109. KENDALL MJ, WOODS KL. Responsiveness to beta-adrenergic receptor stimulation: The effects of age are cardioselective. J Clin Pharmacol 1982;14:821-827.
110. TACK M, ALTOSE M, CHERNIACK N. Effect of aging on the perception of resistive ventilatory loads. Am Rev Respir Dis 1982;126:463-467.
111. CONNOLLY MJ, CROWLEY JJ, CHARAN NB, NIELSON CP, VESTAL RE. Reduced subjective awareness of bronchoconstriction provoked by methacholine in the elderly asthmatic and normal subjects as measured on a simple awareness scale. Thorax 1992;47:410-413.
112. BRISCHETTO MJ, MILLMAN RP, PETERSON PP, GILAGE DA, PACK AI. Effect of aging on ventilatory response to exercise and CO2. J Appl Physiol 1984;56:1143-1150.
113. TACK M, ALTOSE M, CHERNIACK N. Effects of aging on the respiratory sensation produced by elastic loads. J Appl Physiol 1981;50:844-850.
114. BELLIA V, CUTTITTA G, CIBELLA F, et al. Effect of aging on peak expiratory flow variability and nocturnal exacerbations in bronchial asthma. Eur Respir J 1997;10:1803-1808.
115. ULRIK CS, LANGE P. Cigarette smoking and asthma. Monaldi Arch Chest Dis 2001;56:349-353.
116. GODTFREDSEN NS, LANGE P, PRESCOTT E, OSLER M, VESTBO J. Changes in smoking habits and risk of asthma: a longitudinal population based study. Eur Respir J 2001;18:549-554.