Adenoviral-mediated gene transfer to the synovial tissue

Clinical and Experimental Rheumatology

Volumn 20, Issue 3, 2002, Pages 415-419

  Goossens, Paulie H ^a   Huizinga, Tom W J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adenoviral vector; Biodistribution; Gene therapy; Inflammation; Rheumatoid arthritis; Synovial fluid

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CYTOKINE; FAS LIGAND; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; LUCIFERASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR; VIRUS RECEPTOR;

CONTROLLED STUDY; DATA ANALYSIS; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN; IMMUNE RESPONSE; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIOCYTE; SYNOVIUM; T LYMPHOCYTE; TARGET CELL; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS NEUTRALIZATION;

ADENOVIRIDAE; ANIMALS; ARTHRITIS, RHEUMATOID; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; SYNOVIAL MEMBRANE;

EID: 0036559049     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. An in vitro model of synovial cell adhesion and invasiveness into human articular cartilage
2. Gene therapy setback
3. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
4. Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenovirus-mediated in vivo gene transfer to mouse synovium
5. Amelioration of collagen-induced arthritis by CD 95 (Apo-1/Fas)-ligand gene transfer
6. Induction of p16ink4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis
7. Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts
8. Adenovirus mediated gene delivery to the joints of guinea pigs
9. Adenoviral transfer of the viral IL-10 gene peri-articularly to mouse paws suppresses development of CIA in both injected and uninjected paws
10. Adenoviral mediated gene transfer to rabbit synovium in vivo
11. In vivo delivery of genes encoding soluble receptors for IL-1 and TNF-a results in a synergistic therapeutic effect in antigen-induced arthritis in rabbit knee
12. Feasibility of adenovirus-mediated non-surgical synovectomy in CIA affected rhesus monkeys (M. mulatta)
13. The effect of promoter strength in adenoviral vectors in hyperplastic synovium
14. Infection efficiency of type 5 adenoviral vectors to synovial tissue can be enhanced with a type 16 fiber
15. The route administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants
16. Receptor-mediated gene delivery employing adenovirus-polylysine-DNA complexes
17. Adenoviral vector-mediated over expression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction
18. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted adenoviruses
19. Cellular and humoral immune response to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
20. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo
21. Tumor necrosis factor a plays a central role in immune-mediated clearance-of adenoviral vectors
22. Virus proteins that counteract host immune defenses
23. Region E3 of adenovirus: A cassette of genes involved in host immunosurveillance and virus-cell interactions
24. Sequence of immumoregulatory early region 3 and flanking sequences of adenovirus type 35
25. Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer
26. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
27. Viral IL-10 and soluble TNF receptor act synergistically to inhibit collagen-induced arthritis following adenovirus-mediated gene transfer
28. Gene transfer to human rheumatoid synovial tissue engrafted in SCID mice
29. The essentials of DNA methylation
30. Adenovirus binding cultured synoviocytes triggers signaling through the MAPK pathway and induces expression of cyclooxy-genase-2 and interleukin-8
31. Oral tolarization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with pre-existing immunity to adenoviruses
32. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
33. The influence of synovial fluid on adenoviral-mediated gene transfer to the synovial tissue