Regulation of insulin receptor kinase activity by endosomal processes: Possible areas for therapeutic intervention

Current Opinion in Investigational Drugs

Volumn 4, Issue 4, 2003, Pages 430-434

  Posner, Barry I ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Acidification; Endosomes; Insulin receptor kinase; Phosphotyrosine phosphatase; Trafficking

Indexed keywords

2 CARBOMETHOXYBENZOIC ACID DERIVATIVE; 2 OXALYLAMINOBENZOIC ACID DERIVATIVE; ANTIDIABETIC AGENT; BENZOIC ACID DERIVATIVE; CATHEPSIN D; CHLOROQUINE; DIFLUOROMETHYLENE PHOSPHONIC CID DERIVATIVE; DITHIOTHREITOL; INSULIN; INSULIN RECEPTOR KINASE; INSULINASE; LIGAND; PEROXOVANADIUM; PHOSPHONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE; PROTEINASE INHIBITOR; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; VANADIUM DERIVATIVE;

ACIDIFICATION; BINDING AFFINITY; DRUG SYNTHESIS; DRUG TARGETING; ENDOPLASMIC RETICULUM; ENDOSOME; ENZYME ACTIVITY; ENZYME CONFORMATION; HUMAN; INSULIN BINDING; INSULIN DEGRADATION; LIGAND BINDING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN DEPHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ENDOSOMES; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULYSIN; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 0037869027     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

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