A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo

Endocrinology

Volumn 137, Issue 11, 1996, Pages 4960-4968

  Drake, Paul G ^a   Bevan, A Paul ^a   Burgess, James W ^a   Bergeron, John J M ^a   Posner, Barry I ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b Polypeptide Hormone Laboratory   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; PROTEIN TYROSINE KINASE;

ARTICLE; AUTOPHOSPHORYLATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME REGULATION; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; REGULATORY MECHANISM;

EID: 0029828638     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.11.8895369     Document Type: Article

References (45)

1. Kahn CR 1994 Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43:1066-1084
2. Kasuga M, Zick Y, Blithe DL, Crettaz M, Kahn CR 1982 Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system. Nature 298:667-669
3. Tornqvist HE, Avruch J 1988 Relationship of site-specific β-subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity. J Biol Chem 263:4593-4601
4. White MF, Livingston JN, Backer JM, Lauris V, Dull TJ, Ullrich A, Kahn CR 1988 Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity. Cell 54:641-649
5. White MF, Shoelson SE, Keutmann H, Kahn CR 1988 A cascade of tyrosine autophosphorylation in the β-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem 263:2969-2980
6. Herrera R, Rosen O 1986 Autophosphorylation of the insulin receptor in vitro: designation of phosphorylation sites and correlation with receptor kinase activation. J Biol Chem 261:11980-11985
7. Kwok YC, Nemenoff RA, Powers AC, Avruch J 1986 Kinetic properties of the insulin receptor tyrosine protein kinase: activation through an insulin-stimulated tyrosine-specific, intramolecular autophosphorylarion. Arch Biochem Biophys 244:102-113
8. Thies RS, Ullrich A, McClain DA 1989 Augmented mitogenesis and impaired metabolic signaling mediated by a truncated insulin receptor. J Biol Chem 264:12820-12825
9. Takata Y, Webster NJG, Olefsky JM 1991 Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties. J Biol Chem 266:9135-9139
10. Baron V, Gautier N, Kaliman P, Dolais-Kitabgi J, Van Obberghen E 1991 The carboxyl-terminal domain of the insulin receptor: its potential role in growth-promoting effects. Biochemistry 30:9365-9370
11. Takata Y, Webster NJG, Olefsky JM 1992 Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites. J Biol Chem 267:9065-9070
12. Ando A, Momomura K, Tobe K, Yamamoto-Honda R, Sakura H, Tamori Y, Kaburagi Y, Koshio O, Akanuma Y, Yazaki Y, Kasuga M, Kadowaki T 1992 Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylarion sites by phenylalanine. J Biol Chem 267:12788-12796
13. Maegawa H, McClain DA, Freidenberg G, Olefsky JM, Napier M, Lipari T, Dull TJ, Lee J, Ullrich A 1988 Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects. J Biol Chem 263:8912-8917
14. Bevan AP, Drake PG, Yale J-F, Shaver A, Posner BI 1995 Peroxovanadium compounds: biological actions and mechanism of insulin-mimesis. Mol Cell Biochem 153:49-58
15. Morgan DO, Roth RA 1987 Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin. Proc Natl Acad Sci USA 84:41-45
16. Morgan DO, Ho L, Korn LJ, Roth RA 1986 Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase. Proc Natl Acad Sci USA 83:328-332
17. Chou CK, Dull TJ, Russell DS, Gherzi R, Lebwohl D, Ullrich A, Rosen OM 1987 Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin. J Biol Chem 262:1842-1847
18. McClain DA, Maegawa H, Lee J, Dull TJ, Ullrich A, Olefsky JM 1987 A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis. J Biol Chem 262:14663-14671
19. Khan MN, Savoie S, Bergeron JJM, Posner BI 1986 Characterization of rat liver endosomal fractions. In vivo activation of insulin-stimulable receptor kinase in these structures. J Biol Chem 261:8462-8472
20. Khan MN, Baquiran G, Brule C, Burgess J, Foster B, Bergeron JJM, Posner BI 1989 Internalization and activation of the rat liver insulin receptor kinase in vivo. J Biol Chem 264:12931-12940
21. Burgess JW, Wada I, Ling N, Khan MN, Bergeron JJM, Posner BI 1992 Decrease in β-subunit phosphotyrosine correlates with internalization and activation of the endosomal insulin receptor kinase. J Biol Chem 267:10077-10086
22. Burgess JW, Bevan AP, Bergeron JJM, Posner BI 1992 Intracellular trafficking and processing of ligand-receptor complexes in the endosomal system. Exp Clin Endocrinol 11:67-78
23. Baass PC, Di Guglielmo GM, Authier F, Posner BI, Bergeron JJM 1995 Compartmentalized signal transduction by receptor tyrosine kinases. Trends Cell Biol 5:465-470
24. Bevan AP, Drake PG, Bergeron JJM, Posner BI 1996 Intracellular signal transduction: the role of endosomes. Trends Endocrinol Metab 7:13-21
25. Klein HH, Freidenberg GR, Matthaei S, Olefsky JM 1987 Insulin receptor kinase following internalization in isolated rat adipocytes. J Biol Chem 262:10557-10564
26. Kublaoui B, Lee J, Pilch PF 1995 Dynamics of signaling during insulin-stimulated endocytosis of its receptor in adipocytes. J Biol Chem 270:59-65
27. Faure R, Baquiran G, Bergeron JJM, Posner BI 1992 The dephosphorylation of insulin and epidermal growth factor receptors. Role of endosome-associated phosphotyrosine phosphatase(s). J Biol Chem 267:11215-11221
28. Posner BI, Faure R, Burgess JW, Bevan AP, Lachance D, Zhang-Sun G, Fantus IG, Ng JB, Hall DA, Lum BS, Shaver A 1994 Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. J Biol Chem 269:4596-4604
29. 2O, and their reactions with cysteine. Inorg Chem 32:3109-3113
30. Bevan AP, Burgess JW, Drake PG, Shaver A, Bergeron JJM, Posner BI 1995 Selective activation of the rat hepatic endosomal insulin receptor kinase: role for the endosome in insulin signaling. J Biol Chem 270:10784-10791
31. Posner BI, Verma AK, Patel BA, Bergeron JJM 1982 Effect of colchicine on the uptake of prolactin and insulin into Golgi fractions of rat liver. J Cell Biol 93:560-567
32. Khan MN, Savoie S, Khan RJ, Bergeron JJM, Posner BI 1985 Insulin and insulin receptor uptake into rat liver. Chloroquine action on receptor recycling. Diabetes 34:1025-1030
33. Armitage P, Berry G 1987 Statistical Methods in Medical Research. Blackwell, Oxford
34. Fantus IG, Kadota S, Deragon G, Foster B, Posner BI 1989 Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase. Biochemistry 28:8864-8871
35. Burgess JW, Bevan AP, Bergeron JJM, Posner BI 1992 Pharmacological doses of insulin equalize insulin phosphotyrosine content but not tyrosine kinase activity in plasmalemmal and endosomal membranes. Biochem Cell Biol 70:1151-1158
36. Tavare JM, Ramos P, Ellis L 1992 An assessment of human insulin receptor phosphorylation and exogenous kinase activity following deletion of 69 residues from the carboxyl-terminus of the receptor β-subunit. Biochem Biophys Res Commun 188:86-93
37. Bernier M, Liotta AS, Kole HK, Shock DD, Roth J 1994 Dynamic regulation of intact and C-terminal truncated insulin receptor phosphorylation in permeabilized cells. Biochemistry 33:4343-4351
38. Kaliman P, Baron V, Alengrin F, Takata Y, Webster NJG, Olefsky JM, Van Obberghen E 1993 The insulin receptor C-terminus is involved in regulation of the receptor kinase activity. Biochemistry 32:9539-9544
39. Cooper JA, Howell B 1993 The when and how of src regulation. Cell 73:1051-1054
40. Solomon MJ 1993 Activation of the various cyclin/cdc2 protein kinases. Curr Opin Cell Biol 5:180-186
41. Hubbard SR, Wei L, Ellis L, Hendrickson WA 1994 Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372:746-754
42. Taylor SS, Radzio-Andzelm E, Hunter T 1995 How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase. FASEB J 9:1255-1266
43. Tavare JM, Denton RM 1988 Studies on the autophosphorylation of the insulin receptor from human placenta. Biochem J 252:607-615
44. Lee J, Pilch PF 1994 The insulin receptor: structure, function, and signaling. Am J Physiol 266:C319-C334
45. Kadota S, Fantus IG, Deragon G, Guyda HJ, Hersh B, Posner BI 1987 Peroxide(s) of vanadium: a novel and potent insulin-mimetic agent which activates the insulin receptor kinase. Biochem Biophys Res Commun 147:259-266