A single intratracheal dose of the growth factor Fms-like tyrosine kinase receptor-3 ligand induces a rapid differential increase of dendritic cells and lymphocyte subsets in lung tissue and bronchoalveolar lavage, resulting in an increased local antibody production

Journal of Immunology

Volumn 171, Issue 1, 2003, Pages 325-330

  Pabst, Reinhard ^a   Lührmann, Anke ^a   Steinmetz, Ivo ^a   Tschernig, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; FLT3 LIGAND; GROWTH FACTOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; TETANUS TOXOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN PRESENTING CELL; ARTICLE; CELL COUNT; CONTROLLED STUDY; DENDRITIC CELL; DOSE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOSTIMULATION; INTESTINE WALL; LUNG INTERSTITIUM; LUNG LAVAGE; LUNG PARENCHYMA; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; T LYMPHOCYTE; VACCINATION;

EID: 0037868231     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.1.325     Document Type: Article

References (36)

1. Lipscomb, M. F., and B. J. Masten. 2002. Dendritic cells: immune regulators in health and disease. Physiol. Rev. 82:97.
2. Austyn, J. M. 1996. New insights into the mobilization and phagocytic activity of dendritic cells. J. Exp. Med. 183:1287.
3. Rissoan, M. C., V. Soumelis, N. Kadowaki, G. Grouard, F. Briere, R. de Waal-Malefyt, and Y. J. Liu. 1999. Reciprocal control of T helper cell and dendritic cell differentiation. Science 283:1183.
4. Holt, P. G., and P. A. Stumbles. 2000. Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: the respiratory tract as a paradigm. J. Allergy Clin. Immunol. 105:421.
5. Vermaelen, K. Y., I. Carro-Muino, B. N. Lambrecht, and R. A. Pauwels. 2001. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193:51.
6. Vu, Q., K. M. McCarthy, J. M. McCormack, and E. E. Schneeberger. 2002. Lung dendritic cells are primed by inhaled particulate antigens, and retain MHC class II/antigenic peptide complexes in hilar lymph nodes for a prolonged period of time. Immunology 105:488.
7. Julia, V., E. M. Hessel, L. Malherbe, N. Glaichenhaus, A. O'Garra, and R. L. Coffman. 2002. A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity 16:271.
8. Bozza, S., R. Gaziano, A. Spreca, A. Bacci, C. Montagnoli, P. di Francesco, and L. Romani. 2002. Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus, J. Immunol. 168:1362.
9. Cochand, L., P. Isler, F. Songeon, and L. P. Nicod. 1999. Human lung dendritic cells have an immature phenotype with efficient mannose receptors. Am. J. Respir. Cell Mol. Biol. 21:547.
10. De Yang, Q. C., O. Chertov, and J. J. Oppenheim. 2000. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J Leukocyte Biol. 68:9.
11. Hammad, H., C. Duez, O. Fahy, A. Tsicopoulos, C. André, B. Wallaert, S. Lebecque, A. B. Tonnel, and J. Pestel. 2000. Hùman dendritic cells in the severe combined immunodeficiency mouse model: their potentiating role in the allergic reaction. Lab. Invest. 80:605.
12. Akbari, O., R. H. DeKruyff, and D. T. Umetsu. 2001. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immun. 2:725.
13. Lutz, M. B., and G, Schuler. 2002. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 23:445.
14. Fong, L., Y. Hou, A. Rivas, C. Benike, A. Yuen, G. A. Fisher, M. M. Davis, and E. G. Engleman, 2001. Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy. Proc. Natl. Acad Sci. USA 98:8809.
15. Averbook, B. J., J. L. Schuh, R. Papay, and C. Maliszewski. 2002. Antitumor effects of Flt3 ligand in transplanted murine tumor models. J. Immunother. 25:27.
16. Williamson, E., G. M. Westrich, and J. L. Viney. 1999. Modulating dendritic cells to optimize mucosal immunization protocols, J. Immunol. 163:3668.
17. Viney, J. L., A. M. Mowat, J. M. O'Malley, E. Williamson, and N. A. Fanger. 1998. Expanding dendritic cells in vivo enhances the induction of oral tolerance. J. Immunol, 160:5815.
18. Pulendran, B., E. Maraskovsky, J. Banchereau, and C. Maliszewski. 2001. Modulating the immune response with dendritic cells and their growth factors. Trends Immunol. 22:41.
19. McKenna, H. J. 2001. Role of hematopoietic growth factors/flt3 ligand in expansion and regulation of dendritic cells. Curr. Opin. Hematol. 8:149.
20. Gilliet, M., A. Boonstr, C. Paturel, S. Antonenko, X. L. Xu, G. Trinchieri, A. O'Garra, and Y. J. Liu. 2002. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by Flt3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 195:953.
21. Maraskovsky, E., K. Brasel, M. Teepe, E. R. Roux, S. D. Lyman, K. Shortman, and H. J. McKenna. 1996. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J. Exp. Med. 184:1953.
22. Lührmann, A., U. Deiters, J. Skokowa, M. Hanke, J. E. Gessner, P. F. Mühlradt, R. Pabst, and T. Tschernig. 2002. In vivo effects of a synthetic 2-kilodalton macrophage-activating lipopeptide of Mycoplasma fermentans after pulmonary application. Infect. Immun. 70:3785.
23. Shingu, K., C. Kruschinski, A. Lührmann, K. Grote, T. Tschernig, S. von Hörsten, and R. Pabst. 2003. Intratracheal macrophage-activating lipopeptide-2 (MALP-2) reduces metastasis in the rat lung. Am. J. Respir. Cell Mol. Biol. 28:316.
24. Lambrecht, B. N., I. Carro-Muino, K. Vermaelen, and R. A. Pauwels. 1999. Allergen-induced changes in bone-marrow progenitor and airway dendritic cells in sensitized rats. Am. J. Respir. Cell Mol. Biol. 20:1165.
25. Parajuli, P., R. L. Mosley, V. Pisarev, J. Chavez, A. Ulrich, M. Varney, R. K. Singh, and J. E. Talmadge. 2001. Flt3 ligand and granulocyte-macrophage colony-stimulating factor preferentially expand and stimulate different dendritic and T-cell subsets. Exp. Hematol. 29:1185.
26. Stumbles, P. A., J. A. Thomas, C. L. Pimm, P. T. Lee, T. J. Venaille, S. Proksch, and P. G. Holt. 1998. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J. Exp. Med. 188:2019.
27. Stumbles, P. A., D. H. Strickland, C. L. Pimm, S. F. Proksch, A. M. Marsh, A. S. McWilliam, A. Bosco, I. Tobagus, J. A. Thomas, S. Napoli, et al. 2001. Regulation of dendritic cell recruitment into resting and inflamed airway epithelium: use of alternative chemokine receptors as a function of inducing stimulus. J. Immunol. 167:228.
28. Pabst, R., and T. Tschemig. 1997. Lymphocyte dynamics: caution in interpreting BAL numbers. Thorax 52:1078.
29. Pabst, R. 2000. Mucosa-associated lymphoid tissue of the lung: localization, numbers and dynamics of lymphoid cells in the five different compartments. In Asthma and Rhinitis. W. Busse and S. T. Holgate, eds. Blackwell, Oxford, p. 543.
30. Klemm, A., T. Tschemig, N. Krug, and R. Pabst. 1998. Lymphocyte subsets in distinct lung compartments show a different ability to produce interferon-γ (IFNγ) during a pulmonary immune response. Clin. Exp. Immunol. 113:252.
31. Lehmann, C., A. Wilkening, D. Leiber, A. Markus, N. Krug, R. Pabst, and T. Tschemig. 2001. Lymphocytes in the bronchoalveolar space reenter the lung tissue by means of the alveolar epithelium, migrate to regional lymph nodes, and subsequently rejoin the systemic immune system. Anat. Rec. 264:229.
32. Pabst, R., and T. Tschemig. 2002. Perivascular capillaries in the lung: an important but neglected vascular bed in immune reactions? J. Allergy Clin. Immunol. 110:209.
33. + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 15:419.
34. Russell, M. W., M. Kilian, and M. E. Lamm. 1999. Biological activities of IgA. In Mucosal Immunology. P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. Bienenstock, and J. R. McGhee, eds. Academic Press, San Diego, p. 225.
35. Teig, N., D. Moses, S. Gieseler, and U. Schauer. 2002. Age-related changes in human blood dendritic cell subpopulations. Scand J. Immunol. 55:453.
36. Merad, M., T. Sugie, E. G. Engleman, and L. Fong, 2002. In vivo manipulation of dendritic cells to induce therapeutic immunity. Blood 99:1676.