Molecular mechanisms mediating inhibition of G protein-coupled inwardly-rectifying K+ channels

Molecules and Cells

Volumn 15, Issue 1, 2003, Pages 1-9

  Lei, Qiubo ^a   Jones, Miller B ^a   Talley, Edmund M ^a   Garrison, James C ^a   Bayliss, Douglas A ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POTASSIUM; POTASSIUM CHANNEL; PROTEIN SUBUNIT; RECOMBINANT PROTEIN; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL LYASE; PHOSPHOLIPASE C;

ARTICLE; BINDING AFFINITY; DRUG INHIBITION; MOLECULAR MECHANICS; NONHUMAN; PROTEIN BINDING; BINDING COMPETITION; CELL LINE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHEMISTRY; COMPARATIVE STUDY; DIMERIZATION; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; ION TRANSPORT; KIDNEY; METABOLISM; PHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN TERTIARY STRUCTURE; REVIEW;

MAMMALIA;

BINDING, COMPETITIVE; CELL LINE; DIMERIZATION; ENZYME ACTIVATION; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; ION CHANNEL GATING; ION TRANSPORT; KIDNEY; MEMBRANE POTENTIALS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE; PHOSPHOLIPASE C; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0037840616     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. + channel. J. Biol. Chem. 276, 12712-12717.
2. Bayewitch, M. L., Avidor-Reiss, T., Levy, R., Pfeuffer, T., Nevo, I., Simonds, W. F., and Vogel, Z. (1998) Differential modulation of adenylyl cyclases I and II by various Gβ subunits. J. Biol. Chem. 273, 2273-2276.
3. Blake B. L., Wing, M. R., Zhou, J. Y., Lei, Q., Hillman, J. R., Behe, C. I., Morris, R. A., Harden, T. K., Bayliss, D. A., Miller, R. J., and Siderovski, D. P. (2001) Gβ association and effector interaction selectivities of the divergent Gγ subunit Gγ 13. J. Biol. Chem. 276, 49267-49274.
4. Braun, A. P., Fedida, D., and Giles, W. R. (1992) Activation of alpha 1-adrenoceptors modulates the inwardly rectifying potassium currents of mammalian atrial myocytes. Pflugers Arch. Eur. J. Physiol. 421, 431-439.
5. Buck, E., Li, J., Chen, Y., Weng, G., Scarlata, S., and Iyengar, R. (1999) Resolution of a signal transfer region from a general binding domain in Gβ for stimulation of phospholipase C-β2. Science 283, 1332-1335.
6. + channels in mouse atrial myocytes. J. Biol. Chem. 276, 159-164.
7. Clapham, D. E. and Neer, E. J. (1997) G protein βγ subunits. Ann. Rev. Pharmacol. Toxicol. 37, 167-203.
8. + channels. Cell. Signal. 9, 551-573.
9. + conductance in rat midbrain dopaminergic neurons. Neurosci. Lett. 231, 21-24.
10. q α subunit. J. Biol. Chem. 273, 636-644.
11. 2+ channels. J. Neurosci. 18, 9163-9170.
12. Hepler, J. R. (1999) Emerging roles for RGS proteins in cell signalling. Trends Pharmacol. Sci. 20, 376-382.
13. Hilgemann, D. W., Feng, S., and Nasuhoglu, C. (2001) The complex and intriguing lives of PIP2 with ion channels and transporters. Sci. STKE. 2001, RE19.
14. 2 and its stabilization by Gβγ. Nature 391, 803-806.
15. 2+ channels. Neuron 22, 819-829.
16. +-current desensitization. Nat. Cell Biol. 2, 507-514.
17. Kovoor, A., Chen, C. K., He, W., Wensel, T. G., Simon, M. I., and Lester, H. A. (2000) Co-expression of Gβ5 enhances the function of two Gγ subunit-like domain-containing regulators of G protein signaling proteins. J. Biol. Chem. 275, 3397-3402.
18. Kunkel, M. T. and Peralta, E. G. (1995) Identification of domains conferring G protein regulation on inward rectifier potassium channels. Cell 83, 443-449.
19. Lei, Q., Jones, M. B., Talley, E. M., Schrier, A. D., McIntire, W. E., Garrison, J. C., and Bayliss, D. A. (2000) Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein βγ subunits. Proc. Natl. Acad. Sci. USA 97, 9771-9776.
20. q family subunits, phospholipase C, and a readily diffusible messenger. J. Biol. Chem. 276, 16720-16730.
21. Lindorfer, M. A., Myung, C. S., Savino, Y., Yasuda, H., Khazan, R., and Garrison, J. C. (1998) Differential activity of the G protein beta(5)gamma(2) subunit at receptors and effectors. J. Biol. Chem. 273, 34429-34436.
22. + current in atrial myocytes. J. Biol. Chem. 276, 5650-5658.
23. + channels. J. Biol. Chem. 277, 7348-7355.
24. Raucher, D., Stauffer, T., Chen, W., Shen, K., Guo, S., York, J. D., Sheetz, M. P., and Meyer, T. (2000) Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell 100, 221-228.
25. Ruiz-Velasco, V. and Ikeda, S. R. (2000) Multiple G-protein βγ combinations produce voltage-dependent inhibition of N-type calcium channels in rat superior cervical ganglion neurons. J. Neurosci. 20, 2183-2191.
26. Sharon, D., Vorobiov, D., and Dascal, N. (1997) Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes. J. Gen. Physiol. 109, 477-490.
27. Sui, J. L., Petit-Jacques, J., and Logothetis, D. E. (1998) Activation of the atrial KACh channel by the βγ subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates. Proc. Natl. Acad. Sci. USA 95, 1307-1312.
28. Vanner, S., Evans, R. J., Matsumoto, S. G., and Surprenant, A. (1993) Potassium currents and their modulation by muscarine and substance P in neuronal cultures from adult guinea pig celiac ganglia. J. Neurophysiol. 69, 1632-1644.
29. Velimirovic, B. M., Koyano, K., Nakajima, S., and Nakajima, Y. (1995) Opposing mechanisms of regulation of a G-protein-coupled inward rectifier K+ channel in rat brain neurons. Proc. Natl. Acad. Sci. USA 92, 1590-1594.
30. Watson, A. J., Katz, A., and Simon, M. I. (1994) A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C. J. Biol. Chem. 269, 22150-22156.
31. Wickman, K. and Clapham, D. E. (1995) Ion channel regulation by G proteins. Physiol. Rev. 75, 865-885.
32. Wickman, K. D., Iniguez-Lluhl, J. A., Davenport, P. A., Taussig, R., Krapivinsky, G. B., Linder, M. E., Gilman, A. G., and Clapham, D. E. (1994). Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel. Nature 368, 255-257.
33. Xie, L. H., Horie, M., and Takano, M. (1999) Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolism. Proc. Natl. Acad. Sci. USA 96, 15292-15297.
34. Yamaguchi, H., Sakamoto, N., Watanabe, Y., Saito, T., Masuda, Y., and Nakaya, H. (1997) Dual effects of endothelins on the muscarinic K+ current in guinea pig atrial cells. Am. J. Physiol 273, H1745-H1753.
35. Yan, K. and Gautam, N. (1996) A domain on the G protein β subunit interacts with both adenylyl cyclase 2 and the muscarinic atrial potassium channel. J. Biol. Chem. 271, 17597-17600.
36. Zamponi, G. W. (2001) Determinants of G protein inhibition of presynaptic calcium channels. Cell Biochem. Biophys. 34, 79-94.
37. Zhang, S., Coso, O. A., Lee, C., Gutkind, J. S., and Simonds, W. F. (1996) Selective activation of effector pathways by brain-specific G protein β5. J. Biol. Chem. 271, 33575-33579.
38. 2 interactions. Nat. Cell Biol. 1, 183-188.
39. Zhou, J. Y., Siderovski, D. P., and Miller, R. J. (2000) Selective regulation of N-type Ca channels by different combinations of G-protein βγ subunits and RGS proteins. J. Neurosci. 20, 7143-7148.