Receptor-mediated Inhibition of G Protein-coupled Inwardly Rectifying Potassium Channels Involves Gαq Family Subunits, Phospholipase C, and a Readily Diffusible Messenger

Journal of Biological Chemistry

Volumn 276, Issue 20, 2001, Pages 16720-16730

  Lei, Qiubo ^b   Talley, Edmund M ^b   Bayliss, Douglas A ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELL CULTURE; CHEMICAL ACTIVATION; ENZYME INHIBITION; HORMONES; PROTEINS;

MINIGEN CONSTRUCTS;

BIOCHEMISTRY;

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; BACTERIAL TOXIN; CALCIUM ION; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL TRISPHOSPHATE; INWARDLY RECTIFYING POTASSIUM CHANNEL; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN KINASE C; PROTIRELIN; SEROTONIN; TRIPHOSPHOINOSITIDE; 1 (6 ((3 METHOXYESTRA 1,3,5(10) TRIEN 17 YL)AMINO)HEXYL) 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; BACTERIAL PROTEIN; BISINDOLYLMALEIMIDE; ENZYME INHIBITOR; ESTRANE DERIVATIVE; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INDOLE DERIVATIVE; INOSITOL 1,4,5 TRISPHOSPHATE; MALEIMIDE DERIVATIVE; PASTEURELLA MULTOCIDA TOXIN; PHORBOL ESTER; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN SUBUNIT; PROTIRELIN RECEPTOR; RECOMBINANT PROTEIN; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL; KIDNEY CELL; MEMBRANE ELECTROPHYSIOLOGY; PATCH CLAMP; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL LINE; CELL MEMBRANE; CELL MEMBRANE POTENTIAL; CHEMISTRY; DIMERIZATION; DRUG EFFECT; GENETIC TRANSFECTION; METABOLISM; PASTEURELLA MULTOCIDA; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); PASTEURELLA; PASTEURELLA MULTOCIDA;

BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL LINE; CELL MEMBRANE; DIMERIZATION; ENZYME INHIBITORS; ESTRENES; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; INDOLES; INOSITOL 1,4,5-TRISPHOSPHATE; MALEIMIDES; MEMBRANE POTENTIALS; PASTEURELLA MULTOCIDA; PHORBOL ESTERS; PHOSPHOLIPASE C; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN SUBUNITS; PYRROLIDINONES; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, THYROTROPIN-RELEASING HORMONE; RECOMBINANT PROTEINS; SEROTONIN; THYROTROPIN-RELEASING HORMONE; TRANSFECTION;

EID: 0035907310     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100207200     Document Type: Article

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