Neurotensin and dopamine D2 activation oppositely regulate the same K+ conductance in rat midbrain dopaminergic neurons

Neuroscience Letters

Volumn 231, Issue 1, 1997, Pages 21-24

  Farkas, Ronald H ^a,b   Chien, Pei Yu ^a,c   Nakajima, Shigehiro ^a   Nakajima, Yasuko ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Dopamine; Electrophysiology; Interaction; Inward rectifier; Neurotensin; Potassium current; Ventral tegmental area; Whole cell patch clamp

Indexed keywords

DOPAMINE 2 RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); NEUROTENSIN RECEPTOR; POTASSIUM ION; QUINPIROLE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; NONHUMAN; PATCH CLAMP; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY; SIGNAL TRANSDUCTION; VENTRAL TEGMENTUM;

ANIMALS; CELLS, CULTURED; CYCLOLEUCINE; DOPAMINE; DOPAMINE AGONISTS; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTENSIN; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; QUINPIROLE; RATS; RATS, INBRED STRAINS; RECEPTORS, DOPAMINE D2; VENTRAL TEGMENTAL AREA;

EID: 0030759548     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00530-2     Document Type: Article

References (21)

1. Adachi, D.K., Kalivas, P.W. and Schenk, J.O., Neurotensin binding to dopamine, J. Neurochem., 54 (1990) 1321-1328.
2. Aghajanian, G.K. and Bunney, B.S., Dopamine 'autoreceptors': pharmacological characterization by microiontophoretic single cell recording studies, Naunyn-Schmiedeberg's Arch. Pharmacol., 297 (1977) 1-7.
3. 3H-N-propylnorapomorphine binding sites, Acta Physiol. Scand., 119 (1983) 459-461.
4. Cheramy, A., Leviel, V. and Glowinski, J., Dendritic release of dopamine in the substantia nigra, Nature, 289 (1981) 537-542.
5. Farkas, R.H., Chien, P.-Y., Nakajima, S. and Nakajima, Y., Properties of a slow nonselective cation conductance modulated by neurotensin and other neurotransmitters in midbrain dopaminergic neurons, J. Neurophysiol., 76 (1996) 1968-1981.
6. Farkas, R.H., Nakajima, S. and Nakajima, Y., Tachykinins, metabotropic glutamate agonists, and neurotensin excite neurons from the rat ventral tegmental area, Soc. Neurosci. Abstr., 19 (1993) 1263.
7. Farkas, R.H., Nakajima, S. and Nakajima, Y., Neurotensin excites basal forebrain cholinergic neurons: ionic and signal transduction mechanisms, Proc. Natl. Acad. Sci. USA, 91 (1994) 2853-2857.
8. Fuxe, K., O'Connor, W.T., Antonelli, T., Osborne, P.G., Tanganelli, S., Agnati, L.F. and Ungerstedt, U., Evidence for a substrate of neuronal plasticity based on pre- and postsynaptic neurotensin-dopamine receptor interactions in the neostriatum, Proc. Natl. Acad. Sci. USA, 89 (1992) 5591-5595.
9. Innis, R.B. and Aghajanian, G.K., Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra, Brain Res., 411 (1987) 139-143.
10. Jiang, Z.-G., Pessia, M. and North, R.A., Neurotensin excitation of rat ventral tegmental neurones, J. Physiol. (London), 474 (1994) 119-129.
11. Kim, K.-M., Nakajima, S. and Nakajima, Y., Dopamine and GABA receptors in cultured substantia nigra neurons: correlation of electrophysiology and immunocytochemistry, Neuroscience, 78 (1997) 759-769.
12. Kim, K.-M., Nakajima, Y. and Nakajima, S., G protein-coupled inward rectifier modulated by dopamine agonists in cultured substantia nigra neurons, Neuroscience, 69 (1995) 1145-1158.
13. 2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta, J. Physiol. (London), 392 (1987) 397-416.
14. Masuko, S., Nakajima, S. and Nakajima, Y., Dissociated high-purity dopaminergic neuron cultures from the substantia nigra and the ventral tegmental area of the postnatal rat, Neuroscience, 49 (1992) 347-364.
15. + channels in brain neurons requires association of G protein βγ subunits with cell membrane, FEBS Lett., 390 (1996) 217-220.
16. Reuveny, E., Slesinger, P.A., Inglese, J., Morales, J.M., Iñiguez-Lluhi, J.A., Lefkowitz, R.J., Bourne, H.R., Jan, Y.N. and Jan, L.Y., Activation of the cloned muscarinic potassium channel by G protein βγ subunits, Nature, 370 (1994) 143-146.
17. Seutin, V., Massotte, L. and Dresse, A., Electrophysiological effects of neurotensin on dopaminergic neurones of the ventral tegmental area of the rat in vitro, Neuropharmacology, 28 (1989) 949-954.
18. Shi, W.-S. and Bunney, B.S., Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons, Neuropharmacology, 29 (1990) 1095-1097.
19. + channel in rat brain neurons, Proc. Natl. Acad. Sci. USA, 92 (1995) 1590-1594.
20. αq/11 mediates neurotensin excitation of substantia nigra dopaminergic neurons, Mol. Brain Res., 36 (1996) 29-36.
21. Wickman, K.D., Iñiguez-Lluhi, J.A., Davenport, P.A., Taussig, R., Krapivinsky, G.B., Linder, M.E., Gilman, A.G. and Clapham, D.E., Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel, Nature, 368 (1994) 255-257.