Structural and functional consequences of binding site mutations in transferrin: Crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin

Biochemistry

Volumn 42, Issue 23, 2003, Pages 7084-7089

  Baker, Heather M ^a   He, Qing Yu ^b   Briggs, Sara K ^b   Mason, Anne B ^b   Baker, Edward N ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATES; CRYSTAL STRUCTURE; HYDROGEN BONDS; IRON;

HUMAN TRANSFERRIN;

PROTEINS;

ALANINE; ARGININE; ASPARTIC ACID; CARBONIC ACID; CARBOXYL GROUP; FERRIC ION; GLUTAMIC ACID; IRON; TRANSFERRIN;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; HYDROGEN BOND; METAL BINDING; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; PROTON TRANSPORT; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; FERRIC COMPOUNDS; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFERRIN;

EID: 0037794014     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020689f     Document Type: Article

References (34)

1. Klausner, R. D., Ashwell, J. V., Van Renswoude, J. B., Harford, J., and Bridges, K. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 2263-2267.
2. Aisen, P. (1998) Met. Ions Biol. Syst. 35, 585-631.
3. Baker, E. N. (1994) Adv. Inorg. Chem. 41, 389-463.
4. Aisen, R., and Harris, D. C. (1989) in Iron carriers and iron proteins (Loehr, T., Ed.) pp 241-351, VCH Publishers, New York.
5. Grossmann, J. G., Neu, M., Pantos, E., Schwab, F. J., Evans, R. W., Towns-Andrews, E., Lindley, P. F., Appel, H., Thies, W.-G., and Hasnain, S. S. (1992) J. Mol. Biol. 225, 811-819.
6. Anderson, B. F., Baker, H. M., Norris, G. E., Rumball, S. V., and Baker, E. N. (1990) Nature 344, 784-787.
7. Jeffrey, P. D., Bewley, M. C., MacGillivray, R. T. A., Mason, A. B., Woodworth, R. C., and Baker, E. N. (1998) Biochemistry 37, 13978-13986.
8. MacGillivray, R. T. A., Moore, S. A., Chen, J., Anderson, B. F., Baker, H., Luo, Y., Bewley, M., Smith, C. A., Murphy, M. E., Wang, Y., Mason, A. B., Woodworth, R. C., Brayer, G., and Baker, E. (1998) Biochemistry 37, 7919-7928.
9. Baker, H. M., Mason, A. B., He, Q.-Y., and Baker, E. N. (2001) Biochemistry 40, 11670-11675.
10. Baker, E. N., Baker, H. M., Smith, C. A., Stebbins, M. R., Kahn, M., Hellstrom, K. E., and Hellstrom, I. (1992) FEBS Lett. 298, 215-218.
11. Bartfeld, N. S., and Law, J. H. (1990) J. Biol. Chem. 265, 21684-21691.
12. Funk, W. D., MacGillivray, R. T. A., Mason, A. B., Brown, S. A., and Woodworth, R. C. (1990) Biochemistry 29, 1654-1660.
13. Day, C. L., Stowell, K. M., Baker, E. N., and Tweedie, J. W. (1992) J. Biol. Chem. 267, 13857-13862.
14. He, Q.-Y., Mason, A. B., Pakdaman, R., Chasteen, N. D., Dixon, B. K., Tam, B. M., Nguyen, V., MacGillivray, R. T. A., and Woodworth, R. C. (2000) Biochemistry 39, 1205-1210.
15. Nicholson, H., Anderson, B. F., Bland, T., Shewry, S. C., Tweedie, J. W., and Baker, E. N. (1997) Biochemistry 36, 341-346.
16. He, Q.-Y., Mason, A. B., Woodworth, R. C., Tam, B. M., Wadsworth, T., and MacGillivray, R. T. A. (1997) Biochemistry 36, 5522-5528.
17. Grossmann, J. G., Mason, A. B., Woodworth, R. C., Neu, M., Lindley, P. F., and Hasnain, S. S. (1993) J. Mol. Biol. 231, 554-558.
18. Faber, H. R., Bland, T., Day, C. L., Norris, G. E., Tweedie, J. W., and Baker, E. N. (1996) J. Mol. Biol. 256, 352-363.
19. Zak, O., Aisen, P., Crawley, J. B., Joannou, C. L., Patel, K. J., Rafiq, M., and Evans, R. W. (1995) Biochemistry 34, 14428-14434.
20. He, Q.-Y., Mason, A. B., Nguyen, V., MacGillivray, R. T. A., and Woodworth, R. C. (2000) Biochem. J. 350, 909-915.
21. Faber, H. R., Baker, C. J., Day, C. L., Tweedie, J. W., and Baker, E. N. (1996) Biochemistry 35, 14473-14479.
22. Woodworth, R. C., Mason, A. B., Funk, W. D., and MacGillivray, R. T. A. (1991) Biochemistry 30, 10824-10829.
23. MacGillivray, R. T. A., Bewley, M. C., Smith, C. A., He, Q.-Y., Mason, A. B., Woodworth, R. C., and Baker, E. N. (2000) Biochemistry 39, 1211-1216.
24. Nurizzo, D., Baker, H. M., He, Q.-Y., MacGillivray, R. T. A., Mason, A. B., Woodworth, R. C., and Baker, E. N. (2001) Biochemistry, 40, 1616-1623.
25. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D54, 905-921.
26. Cambillau, C., Roussel, A., Inisan, A.-G., and Knoops-Mouthuy, E. (1996) Bio-Graphics, AFMB-CNRS, Marseille, France.
27. Brunger, A. T. (1992) Nature 355, 472-474.
28. Engh, R. A., and Huber, R. (1991) Acta Crystallogr. A47, 392-400.
29. Laskowski, R., MacArthur, M., Moss, D., and Thomton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291.
30. He, Q.-Y., Mason, A. B., and Woodworth, R. C. (1997) Biochem. J. 328, 439-445.
31. He, Q.-Y., and Mason, A. B. (2002) in Molecular and Cellular Iron Transport (Templeton, D. M., Ed.) pp 95-123, Marcel Dekker, New York.
32. el Hage Chahine, J. M., and Pakdaman, R. (1995) Eur. J. Biochem. 230, 1102-1110.
33. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
34. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524.