Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine 'trigger' but does not significantly affect iron release

Biochemistry

Volumn 39, Issue 6, 2000, Pages 1211-1216

  MacGillivray, Ross T A ^a,b   Bewley, Maria C ^a,e   Smith, Clyde A ^d   He, Qing Yu ^c   Mason, Anne B ^c   Woodworth, Robert C ^c   Baker, Edward N ^a,d  

^a MASSEY UNIVERSITY   (New Zealand)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF VERMONT   (United States)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

^e BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTIDINE; IRON; LIGAND; TRANSFERRIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL BOND; CRYSTAL STRUCTURE; IRON KINETICS; IRON TRANSPORT; NONHUMAN; PH; PRIORITY JOURNAL; REACTION ANALYSIS;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; GLUTAMIC ACID; HISTIDINE; HUMANS; IRON; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TRANSFERRIN;

ANIMALIA;

EID: 0034673090     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991522y     Document Type: Article

References (37)

1. Harris, D. C., and Aisen, P. (1989) in Iron Carriers and Iron Proteins (Loehr, T. M., Ed.) pp 241-351, VCH Publishers, New York.
2. Baker, E. N. (1994) Adv. Inorg. Chem. 41, 389-463.
3. Klausner, R. D., Ashwell, J. V., Van Renswoude, J. B., Harford, J., and Bridges, K. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 2263-2267.
4. MacGillivray, R. T. A., Mendez, E., Shewale, J. G., Sinha, S. K., Lineback-Zins, J., and Brew, K. (1983) J. Biol. Chem. 258, 3543-3553.
5. Bailey, S., Evans, R. W., Garratt, R. C., Gorinsky, B., Hasnain, S., Horsburgh, C., Jhoti, H., Lindley, P. F., Mydin, A., Sarra, R., and Watson, J. L. (1988) Biochemistry 27, 5804-5812.
6. Anderson, B. F., Baker, H. M., Dodson, E. J., Norris, G. E., Rumball, S. V., Waters, J. M., and Baker, E. N. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 1769-1773.
7. Anderson, B. F., Baker, H. M., Norris, G. E., Rice, D. W., and Baker, E. N. (1989) J. Mol. Biol. 209, 711-734.
8. Kurokawa, H., Mikami, B., and Hirose, M. (1995) J. Mol. Biol. 254, 196-207.
9. Woodworth, R. C., Mason, A. B., Funk, W. D., and MacGillivray, R. T. A. (1991) Biochemistry 30, 10824-10829.
10. He, Q.-Y., Mason, A. B., Woodworth, R. C., Tam, B. M., Wadsworth, T., and MacGillivray, R. T. A. (1997) Biochemistry 36, 5522-5528.
11. He, Q.-Y., Mason, A. B., Woodworth, R. C., Tam, B. M., MacGillivray, R. T. A., Grady, J. K., and Chasteen, N. D. (1997) Biochemistry 36, 14853-14860.
12. Zak, O., Aisen, P., Crawley, J. B., Joannou, C. L., Patel, K. J., Rafiq, M., and Evans, R. W. (1995) Biochemistry 34, 14428-14434.
13. Faber, H. R., Baker, C. J., Day, C. L., Tweedie, J. W., and Baker, E. N. (1996) Biochemistry 35, 14473-14479.
14. Nicholson, H., Anderson, B. F., Bland, T., Shewry, S. C., Tweedie, J. W., and Baker, E. N. (1997) Biochemistry 36, 341-346.
15. MacGillivray, R. T. A., Moore, S. A., Chen, J., Anderson, B. F., Baker, H., Luo, Y., Bewley, M., Smith, C. A., Murphy, M. E. P., Wang, Y., Mason, A. B., Woodworth, R. C., Brayer, G. D., and Baker, E. N. (1998) Biochemistry 37, 7919-7928.
16. Jeffrey, P. D., Bewley, M. C., MacGillivray, R. T. A., Mason, A. B., Woodworth, R. C., and Baker, E. N. (1998) Biochemistry 37, 13978-13986.
17. Anderson, B. F., Baker, H. M., Norris, G. E., Rumball, S. V., and Baker, E. N. (1990) Nature (London) 344, 787-790.
18. Bali, P. K., and Aisen, P. (1991) Biochemistry 30, 9947-9953.
19. El Hage Chahine, J.-M., and Pakdaman, R. (1995). Eur. J. Biochem 230, 1102-1110.
20. Dewan, J. C., Mikami, B., Hirose, M., and Sacchettini, J. C. (1993) Biochemistry 32, 11963-11968.
21. He, Q.-Y., Mason, A. B., Dixon, B. K., Tam, B. M., MacGillivray, R. T. A., Pakdaman, R., Chasteen, N. D., and Woodworth, R. C. (1999) Biochemistry 39, 1205-1210.
22. Funk, W. D., MacGillivray, R. T. A., Mason, A. B., Brown, S. A., and Woodworth, R. C. (1990) Biochemistry 29, 1654-1660.
23. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326.
24. Collaborative Computing Project 4 (1994) Acta Crystallogr., Sect. D 50, 760-763.
25. Brunger, A. T. (1992) X-Plor version 3.1. A System for Crystallography and NMR, Yale University Press, New Haven, CT.
26. Engh, R. A., and Huber, R. (1991) Acta Crystallogr., Sect. A 47, 392-400.
27. Jones, T. A., Zou, J.-Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr., Sect. A 47, 110-119.
28. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291.
29. Day, C. L., Anderson, B. F., Tweedie, J. W., and Baker, E. N. (1993) J. Mol. Biol. 232, 1084-1100.
30. Howard, J. B., and Rees, D. C. (1991) Adv. Protein Chem. 42, 199-280.
31. Hart, P. J., Nersissian, A. M., Herrmann, R. G., Nalbandyan, R. M., Valentine, J. S., and Eisenberg, D. (1996) Protein Sci. 5, 2175-2183.
32. Bruns, C. M., Nowalk, A. J., Arvai, A. S., McTigue, M. A., Vaughan, K. G., Mietzner, T. A., and McRee, D. E. (1997) Nat. Struct. Biol. 4, 919-923.
33. Baker, E. N. (1997) Nat. Struct. Biol. 4, 869-871.
34. Bartfeld, N. S., and Law, J. H. (1990) J. Biol. Chem. 265, 21684-21691.
35. Jamroz, R. C., Gasdaska, J. R., Bradfield, J. Y., and Law, J. H. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 1320-1324.
36. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
37. Merritt, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr., Sect. D 50, 869-873.