Mutagenesis of the histidine ligand in human lactoferrin: Iron binding properties and crystal structure of the histidine-253 → methionine mutant

Biochemistry

Volumn 36, Issue 2, 1997, Pages 341-346

  Nicholson, Hale ^a   Anderson, Bryan F ^a   Bland, Tony ^a   Shewry, Steven C ^a   Tweedie, John W ^a   Baker, Edward N ^a  

^a MASSEY UNIVERSITY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC ION; HISTIDINE; IRON BINDING PROTEIN; LACTOFERRIN; METHIONINE; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; HUMAN; LIGAND BINDING; METAL BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; CELL LINE; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; IRON; KIDNEY; LACTOFERRIN; METHIONINE; MODELS, MOLECULAR; MODELS, STRUCTURAL; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; TRANSFECTION;

CRICETINAE;

EID: 0031038477     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961908y     Document Type: Article

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