Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: Crystal structures of R121S and R121E mutants

Biochemistry

Volumn 35, Issue 46, 1996, Pages 14473-14479

  Faber, H Rick ^a   Baker, Christina J ^a   Day, Catherine L ^a   Tweedie, John W ^a   Baker, Edward N ^a  

^a MASSEY UNIVERSITY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; ARGININE; GLUTAMIC ACID; LACTOFERRIN; MUTANT PROTEIN; SERINE; TRANSFERRIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; IRON METABOLISM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PURIFICATION; PROTEIN STABILITY;

ANIONS; ARGININE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN-ION CONCENTRATION; IRON; LACTOFERRIN; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION;

EID: 0030462358     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961729g     Document Type: Article

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