Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability during cholesterol lowering in rabbits

Journal of Cardiovascular Pharmacology

Volumn 41, Issue 6, 2003, Pages 970-978

  De Meyer, Guido R Y ^a   Kockx, Mark M ^a,b   Knaapen, Michiel W M ^c   Martinet, Wim ^a   De Cleen, Dieter M M ^a   Bult, Hidde ^a   Herman, Arnold G ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b MIDDELHEIM HOSPITAL   (Belgium)

^c HistoGeneX NV   (Belgium)

Author keywords

Atherosclerosis; Atherosclerotic plaque; Cholesterol; Molsidomine; Nitric oxide

Indexed keywords

CHOLESTEROL; MESSENGER RNA; MOLSIDOMINE; NITRIC OXIDE SYNTHASE; SUPEROXIDE DISMUTASE; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL COMPOSITION; CELL DIVISION; CONTROLLED STUDY; FOAM CELL; MACROPHAGE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT;

ACETONITRILES; ANIMALS; AORTA; APOPTOSIS; ARTERIOSCLEROSIS; BODY WEIGHT; CHOLESTEROL; CHOLESTEROL, DIETARY; ENDOTHELIUM, VASCULAR; MACROPHAGES; MALE; MOLSIDOMINE; MORPHOLINES; NITRIC OXIDE DONORS; RABBITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPEROXIDE DISMUTASE; SUPEROXIDES; TIME FACTORS;

EID: 0037780682     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200306000-00021     Document Type: Article

References (29)

1. Davies MJ, Woolf N, Rowles P, et al. Lipid and cellular constituents of unstable human aortic plaques. Basic Res Cardiol. 1994;89 Suppl 1:33-39.
2. Kockx MM, De Meyer GRY, Bortier H, et al. Luminal foam cell accumulation is associated with smooth muscle cell death in the intimal thickening of human saphenous vein grafts. Circulation. 1996;94:1255-62.
3. Aikawa M, Rabkin E, Sugiyama S, et al. An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation. 2001;103:276-83.
4. Crisby M, Nordin-Frederiksson G, Shah PK, et al. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation. 2001;103:926-33.
5. Mohr S, McCormick TS, Lapetina EG. Macrophages resistant to endogenously generated nitric oxide-mediated apoptosis are hypersensitive to exogenously added nitric oxide donors: dichotomous apoptotic response independent of caspase 3 and reversal by the mitogen-activated protein kinase kinase (MEK) inhibitor PD 098059. Proc Natl Acad Sci U S A. 1998;95:5045-50.
6. De Meyer GRY, Bult H, Üstünes L, et al. Effect of nitric oxide donors on neointima formation and vascular reactivity in the collared carotid artery of rabbits. J Cardiovasc Pharmacol. 1995;26:272-79.
7. Bult H, De Meyer GRY, Herman AG. Influence of chronic treatment with a nitric oxide donor on fatty streak development and reactivity of the rabbit aorta. Br J Pharmacol. 1995;114:1371-82.
8. Behr D, Rupin A, Fabiani JN, et al. Distribution and prevalence of inducible nitric oxide synthase in atherosclerotic vessels of long-term cholesterol-fed rabbits. Atherosclerosis. 1999;142:335-44.
9. Feelisch M, Ostrowski J, Noack E. On the mechanism of NO release from sydnonimines. J Cardiovasc Pharmacol. 1989;14, suppl. 11:S13-S22.
10. Singh RJ, Hogg N, Joseph J, et al. The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors. Arch Biochem Biophys. 1999;361:331-39.
11. Reden J. Molsidomine. Blood Vessels. 1990;27:282-94.
12. Wildgrube HJ, Ostrowski J, Chamberlain J, et al. Liver function and pharmacokinetics of molsidomine and its metabolite 3-morpholinosydnonimine in healthy volunteers. Arzneimittelforschung. 1986;36:1129-33.
13. Kockx MM, De Meyer GRY, Buyssens N, et al. Cell composition, replication, and apoptosis in atherosclerotic plaques after 6 months of cholesterol withdrawal. Circ Res. 1998;83:378-87.
14. Kockx MM, Muhring J, Knaapen MWM, et al. RNA synthesis and splicing interferes with DNA in situ end labeling techniques to detect apoptosis. Am J Pathol. 1998;152:885-88.
15. Bauersachs J, Bouloumié A, Fraccarollo D, et al. Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial nitric oxide synthase and soluble guanylate cyclase expression. Role of enhanced vascular superoxide production. Circulation. 1999;100:292-98.
16. Afanas'ev IB, Ostrachovitch EA, Korkina LG. Lucigenin is a mediator of cytochrome c reduction but not of superoxide production. Arch Biochem Biophys. 1999;366:267-74.
17. Afanas'ev IB. Lucigenin chemiluminescence assay for superoxide detection. Circ Res. 2001;89:e46.
18. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-59.
19. Mügge A, Brandes RP, Böger RH, et al. Vascular release of superoxide radicals is enhanced in hypercholesterolemic rabbits. J Cardiovasc Pharmacol. 1994;24:994-98.
20. Brandes RP, Dwenger A, Mugge A. The basal and stimulated release of the endothelium-derived relaxing factor from isolated pig coronary arteries does not interfere with the vascular release of superoxide. Naunyn Schmiedebergs Arch Pharmacol. 1994;349:183-87.
21. Benov L, Sztejnberg L, Fridovich I. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Radic Biol Med. 1998;25:826-31.
22. Strålin P, Karlsson K, Johansson BO, et al. The interstitium of the human arterial wall contains very large amounts of extracellular superoxide dismutase. Arterioscler Thromb Vasc Biol. 1995;15:2032-36.
23. Gerrity RG. The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions. Am J Pathol. 1981;103:191-200.
24. Zampolli A, Basta G, Lazzerini G, et al. Inhibition of endothelial cell activation by nitric oxide donors. J Pharmacol Exp Ther. 2000;295:818-23.
25. Kojda G, Hacker A, Noack E. Effects of nonintermittent treatment of rabbits with pentaerythritol tetranitrate on vascular reactivity and superoxide production. Eur J Pharmacol. 1998;355:23-31.
26. Xia Y, Roman LJ, Masters BSS, et al. Inducible nitric-oxide synthase generates superoxide from the reductase domain. J Biol Chem. 1998;273:22635-39.
27. Hacker A, Müller S, Meyer W, et al. The nitric oxide donor pentaerythritol tetranitrate can preserve endothelial function in established atherosclerosis. Br J Pharmacol. 2001;132:1707-14.
28. Fukai T, Siegfried MR, Ushio-Fukai M, et al. Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training. J Clin Invest. 2000;105:1631-39.
29. Paravicini TM, Gulluyan LM, Dusting GJ, et al. Increased NADPH oxidase activity, gp91phox expression, and endothelium-dependent vasorelaxation during neointima formation in rabbits. Circ Res. 2002;91:54-61.