Synthesis of [L-Ala-1]RA-VII, [D-Ala-2]RA-VII, and [D-Ala-4]RA-VII by epimerization of RA-VII, an antitumor bicyclic hexapeptide from rubia plants, through oxazoles

Journal of the American Chemical Society

Volumn 125, Issue 24, 2003, Pages 7284-7290

  Hitotsuyanagi, Yukio ^a   Sasaki, Shin ichi ^a   Matsumoto, Yuji ^a   Yamaguchi, Kentaro ^b   Itokawa, Hideji ^a   Takeya, Koichi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; HYDROGEN BONDS; HYDROLYSIS; PLANTS (BOTANY); SYNTHESIS (CHEMICAL);

SIDE CHAINS;

POLYPEPTIDES;

ANTINEOPLASTIC AGENT; CYCLIC HEXAPEPTIDE RA VII [1 ALANINE]; CYCLIC HEXAPEPTIDE RA VII [2 DEXTRO ALANINE]; CYCLIC HEXAPEPTIDE RA VII [4 DEXTRO ALANINE]; HEXAPEPTIDE; RUBIA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; EPIMERIZATION; HYDROGEN BOND; HYDROLYSIS; MOLECULAR STABILITY; MOUSE; NONHUMAN; RUBIACEAE;

ALANINE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; IMIDOESTERS; MODELS, MOLECULAR; OXAZOLES; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; RUBIACEAE; THIOAMIDES;

EID: 0037774455     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja021131y     Document Type: Article

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