Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media

Infection and Immunity

Volumn 71, Issue 6, 2003, Pages 3454-3462

  Mason, Kevin M ^a   Munson Jr , Robert S ^a   Bakaletz, Lauren O ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; ENZYME; GREEN FLUORESCENT PROTEIN; REGULATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CHINCHILLA; CHRONIC OTITIS MEDIA; CONTROLLED STUDY; DNA FLANKING REGION; DNA SEQUENCE; FLUORESCENCE; FLUORESCENCE ACTIVATED CELL SORTER; GENE EXPRESSION; GENE INDUCTION; GENE SEQUENCE; HAEMOPHILUS INFLUENZAE; MICROENVIRONMENT; MOLECULAR CLONING; MORAXELLA CATARRHALIS; NONHUMAN; OTITIS MEDIA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ISOLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETORY OTITIS MEDIA; STREPTOCOCCUS PNEUMONIAE;

ACUTE DISEASE; ANIMALS; CHINCHILLA; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, BACTERIAL; GREEN FLUORESCENT PROTEINS; HAEMOPHILUS INFLUENZAE; LUMINESCENT PROTEINS; OTITIS MEDIA; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0037767125     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.6.3454-3462.2003     Document Type: Article

References (54)

1. Akerley, B. J., E. J. Rubin, V. L. Novick, K. Amaya, N. Judson, and J. J. Mekalanos. 2002. A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proc. Natl. Acad. Sci. USA 99:966-971.
2. Badger, J. L., C. A. Wass, and K. S. Kim. 2000. Identification of Escherichia coli K1 genes contributing to human brain microvascular endothelial cell invasion by differential fluorescence induction. Mol. Microbiol. 36:174-182.
3. Bakaletz, L. O., R. L. Daniels, and D. J. Lim. 1993. Modeling adenovirus type 1-induced otitis media in the chinchilla: effect on ciliary activity and fluid transport function of eustachian tube mucosal epithelium. J. Infect. Dis. 168:865-872.
4. Bakaletz, L. O., and K. A. Holmes. 1997. Evidence for transudation of specific antibody into the middle ears of parenterally immunized chinchillas after an upper respiratory tract infection with adenovirus. Clin. Diagn. Lab. Immunol. 4:223-225.
5. Bakaletz, L. O., B. J. Kennedy, L. A. Novotny, G. Duquesne, J. Cohen, and Y. Lobet. 1999. Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection. Infect. Immun. 67:2746-2762.
6. Bakaletz, L. O., E. R. Leake, J. M. Billy, and P. T. Kaumaya. 1997. Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla. Vaccine 15:955-961.
7. Baldwin, R. L. 1993. Effects of otitis media on child development. Am. J. Otol. 14:601-604.
8. Baltes, N., W. Tonpitak, G. F. Gerlach, I. Hennig-Pauka, A. HoffmannMoujahid, M. Ganter, and H. J. Rothkotter. 2001. Actinobacillus pleuropneumoniae iron transport and urease activity: effects on bacterial virulence and host immune response. Infect. Immun. 69:472-478.
9. Bartilson, M., A. Marra, J. Christine, J. S. Asundi, W. P. Schneider, and A. E. Hromockyj. 2001. Differential fluorescence induction reveals Streptococcus pneumoniae loci regulated by competence stimulatory peptide, Mol. Microbiol. 39:126-135.
10. Black, S., H. Shinefield, B. Fireman, E. Lewis, P. Ray, J. R. Hansen, L. Elvin, K. M. Ensor, J. Hackell, G. Siber, F. Malinoski, D. Madore, I. Chang, R. Kohberger, W. Watson, R. Austrian, and K. Edwards. 2000. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr. Infect. Dis. J. 19:187-195.
11. Bosse, J. T., and J. I. MacInnes. 2000. Urease activity may contribute to the ability of Actinobacillus pleuropneumoniae to establish infection. Can. J. Vet. Res. 64:145-150.
12. Chalfie, M., Y. Tu, G. Euskirchen, W. W. Ward, and D. C. Prasher. 1994. Green fluorescent protein as a marker for gene expression. Science 263:802-805.
13. Clarke, L., and J. Carbon. 1976. A colony bank containing synthetic ColE1 hybrid plasmids representative of the entire E. coli genome. Cell 9:91-99.
14. Cormack, B. P., R. H. Valdivia, and S. Falkow. 1996. FACS-optimized mutants of the green fluorescent protein (GFP). Gene 173:33-38.
15. DeMaria, T. F., D. J. Lim, J. Barnishan, L. W. Ayers, and H. G. Birck. 1984. Biotypes of serologically nontypeable Haemophilus influenzae isolated from the middle ears and nasopharynges of patients with otitis media with effusion. J. Clin. Microbiol. 20:1102-1104.
16. Dhandayuthapani, S., L. E. Via, C. A. Thomas, P. M. Horowitz, D. Deretic, and V. Deretic. 1995. Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages. Mol. Microbiol. 17:901-912.
17. Dunn, A. K., and J. Handelsman. 1999. A vector for promoter trapping in Bacillus cereus. Gene 226:297-305.
18. Ehrlich, G. D., R. Veeh, X. Wang, J. W. Costerton, J. D. Hayes, F. Z. Hu, B. J. Daigle, M. D. Ehrlich, and J. C. Post. 2002. Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media. JAMA 287:1710-1715.
19. Eskola, J., and T. Kilpi. 2000. Potential of bacterial vaccines in the prevention of acute otitis media. Pediatr. Infect. Dis. J. 19:S72-S78.
20. Eskola, J., T. Kilpi, A. Palmu, J. Jokinen, J. Haapakoski, E. Herva, A. Takala, H. Kayhty, P. Karma, R. Kohberger, G. Siber, and P. H. Makela. 2001. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N. Engl. J. Med. 344:403-409.
21. Eskra, L., A. Canavessi, M. Carey, and G. Splitter. 2001. Brucella abortus genes identified following constitutive growth and macrophage infection. Infect. Immun. 69:7736-7742.
22. Fuller, T. E., R. J. Shea, B. J. Thacker, and M. H. Mulks. 1999. Identification of in vivo induced genes in Actinobacillus pleuropneumoniae. Microb. Pathog. 27:311-327.
23. Hunter, L. L., R. H. Margolis, and G. S. Giebink. 1994. Identification of hearing loss in children with otitis media. Ann. Otol. Rhinol. Laryngol. Suppl. 163:59-61.
24. Infante-Rivard, C., and A. Fernandez. 1993. Otitis media in children: frequency, risk factors, and research avenues. Epidemiol. Rev. 15:444-465.
25. Kaplan, B., T. L. Wandstrat, and J. R. Cunningham. 1997. Overall cost in the treatment of otitis media. Pediatr. Infect. Dis. J. 16:S9-S11.
26. Kennedy, B. J., L. A. Novotny, J. A. Jurcisek, Y. Lobet, and L. O. Bakaletz. 2000. Passive transfer of antiserum specific for immunogens derived from a nontypeable Haemophilus influenzae adhesin and lipoprotein D prevents otitis media after heterologous challenge. Infect. Immun. 68:2756-2765.
27. Klein, J. O. 1997. Role of nontypeable Haemophilus influenzae in pediatric respiratory tract infections. Pediatr. Infect. Dis. J. 16:S5-S8.
28. Lee, A. K., and S. Falkow. 1998. Constitutive and inducible green fluorescent protein expression in Bartonella henselae. Infect. Immun. 66:3964-3967.
29. Lopez-Solanilla, E., F. Garcia-Olmedo, and P. Rodriguez-Palenzuela. 1998. Inactivation of the sapA to sapF locus of Erwinia chsysanthemi reveals common features in plant and animal bacterial pathogenesis. Plant Cell 10:917-924.
30. Lysenko, E. S., J. Gould, R. Bals, J. M. Wilson, and J. N. Weiser. 2000. Bacterial phosphorylcholine decreases susceptibility to the antimicrobial peptide LL-37/hCAP18 expressed in the upper respiratory tract. Infect. Immun. 68:1664-1671.
31. Macfadyen, L. P., I. R. Dorocicz, J. Reizer, M. H. Saier, Jr., and R. J. Redfield. 1996. Regulation of competence development and sugar utilization in Haemophilus influenzae Rd by a phosphoenolpyruvate:fructose phosphotransferase system. Mol. Microbiol. 21:941-952.
32. Marra, A., J. Asundi, M. Bartilson, S. Lawson, F. Fang, J. Christine, C. Wiesner, D. Brigham, W. P. Schneider, and A. E. Hromockyj. 2002. Differential fluorescence induction analysis of Streptococcus pneumoniae identifies genes involved in pathogenesis. Infect. Immun. 70:1422-1433.
33. Marra, A., S. Lawson, J. S. Asundi, D. Brigham, and A. E. Hromockyj. 2002. In vivo characterization of the psa genes from Streptococcus pneumoniae in multiple models of infection. Microbiology 148:1483-1491.
34. Mitchell, M. A., K. Skowronek, L. Kauc, and S. H. Goodgal. 1991. Electroporation of Haemophilus influenzae is effective for transformation of plasmid but not chromosomal DNA. Nucleic Acids Res. 19:3625-3628.
35. Miyamoto, N., and L. O. Bakaletz. 1996. Selective adherence of non-typeable Haemophilus influenzae (NTHi) to mucus or epithelial cells in the chinchilla eustachian tube and middle ear. Microb. Pathog. 21:343-356.
36. Pelton, S. I., and J. O. Klein. 2002. The future of pneumococcal conjugate vaccines for prevention of pneumococcal diseases in infants and children. Pediatrics 110:805-814.
37. Runyen-Janecky, L. J., and S. M. Payne. 2002. Identification of chromosomal Shigella flexneri genes induced by the eukaryotic intracellular environment. Infect. Immun. 70:4379-4388.
38. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
39. Schneider, W. P., S. K. Ho, J. Christine, M. Yao, A. Marra, and A. E. Hromockyj. 2002. Virulence gene identification by differential fluorescence induction analysis of Staphylococcus aureus gene expression during infectionsimulating culture. Infect. Immun. 70:1326-1333.
40. Snow, J. B., Jr. 2002. Progress in the prevention of otitis media through immunization. Otol. Neurotol. 23:1-2.
41. Spinola, S. M., J. Peacock, F. W. Denny, D. L. Smith, and J. G. Cannon. 1986. Epidemiology of colonization by nontypeable Haemophilus influenzae in children: a longitudinal study. J. Infect. Dis. 154:100-109.
42. Suzuki, K., and L. O. Bakaletz. 1994. Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis media. Infect. Immun. 62:1710-1718.
43. Teele, D. W., J. O. Klein, C. Chase, P. Menyuk, and B. A. Rosner. 1990. Otitis media in infancy and intellectual ability, school achievement, speech, and language at age 7 years. J. Infect. Dis. 162:685-694.
44. Tong, H. H., L. E. Blue, M. A. James, Y. P. Chen, and T. F. DeMaria. 2000. Evaluation of phase variation of nontypeable Haemophilus influenzae lipooligosaccharide during nasopharyngeal colonization and development of otitis media in the chinchilla model. Infect. Immun. 68:4593-4597.
45. Valdivia, R. H., and S. Falkow. 1996. Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction. Mol. Microbiol. 22:367-378.
46. Valdivia, R. H., and S. Falkow. 1998. Flow cytometry and bacterial pathogenesis. Curr. Opin. Microbiol. 1:359-363.
47. Valdivia, R. H., and S. Falkow. 1997. Fluorescence-based isolation of bacterial genes expressed within host cells. Science 277:2007-2011.
48. van Ulsen, P., M. van Schilfgaarde, J. Dankert, H. Jansen, and L. van Alphen. 2002. Genes of non-typeable Haemophilus influenzae expressed during interaction with human epithelial cell lines. Mol. Microbiol. 45:485-500.
49. Wang, J., A. Mushegian, S. Lory, and S. Jin. 1996. Large-scale isolation of candidate virulence genes of Pseudomonas aeruginosa by in vivo selection. Proc. Natl. Acad. Sci. USA 93:10434-10439.
50. Weiser, J. N., N. Pan, K. L. McGowan, D. Musher, A. Martin, and J. Richards. 1998. Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein. J. Exp. Med. 187:631-640.
51. Weiser, J. N., M. Shchepetov, and S. T. Chong. 1997. Decoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzae. Infect. Immun. 65:943-950.
52. West, S. E., M. J. Romero, L. B. Regassa, N. A. Zielinski, and R. A. Welch. 1995. Construction of Actinobacillus pleuropneumoniae-Escherichia coli shuttle vectors: expression of antibiotic-resistance genes. Gene 160:81-86.
53. Wilson, P. L., A. R. Tvinnereim, B. D. Jones, and J. T. Harty. 2001. Identification of Listeria monocytogenes in vivo-induced genes by fluorescenceactivated cell sorting. Infect. Immun. 69:5016-5024.
54. Young, G. M., D. Amid, and V. L. Miller. 1996. A bifunctional urease enhances survival of pathogenic Yersinia enterocolitica and Morganella morganii at low pH. J. Bacteriol. 178:6487-6495.