Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media

JAMA

Volumn 287, Issue 13, 2002, Pages 1710-1715

  Ehrlich, Garth D ^a,b   Veeh, Richard ^c   Wang, Xue ^a,b   William Costerton, J ^c   Hayes, Jay D ^a   Hu, Fen Ze ^a,b   Daigle, Bernie J ^a   Ehrlich, Miles D ^a   Christopher Post, J ^a  

^a ALLEGHENY SINGER RESEARCH INSTITUTE   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c MONTANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIUM DETECTION; BIOFILM; CHINCHILLA; CHRONIC OTITIS MEDIA; COLONY FORMATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EUTHANASIA; EXPERIMENTAL MODEL; HAEMOPHILUS INFLUENZAE; IMAGE ANALYSIS; MIDDLE EAR EFFUSION; MIDDLE EAR MUCOSA; MORPHOLOGY; MORTALITY; NONHUMAN; OTITIS MEDIA; PATHOGENESIS; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; VITAL STAIN;

EID: 0037012458     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.287.13.1710     Document Type: Article

References (43)

1. The burden of otitis media
2. The heritability of otitis media: A twin and triplet study
3. Susceptibility to otitis media: Strong evidence that genetics plays a role
4. Meta-analysis of antibiotics for the treatment of otitis media with effusion
5. Molecular analysis of bacterial pathogens in otitis media with effusion
6. Correlation between presence of viable bacteria and presence of endotoxin in middle-ear effusions
7. Endotoxin in middle-ear effusions from patients with chronic otitis media with effusion
8. PCR-based detection of bacterial DNA after antimicrobial treatment is indicative of persistent, viable bacteria in the chinchilla model of otitis media
9. Evidence of bacteria metabolic activity in culture-negative otitis media with effusion
10. Forging a link between biofilms and disease
11. The impact of the polymerase chain reaction in clinical medicine
12. Mechanisms of biofilm resistance to antimicrobial agents
13. Battling biofilms
14. Modified penicillin enrichment procedure for the selection of bacterial mutants
15. Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A
16. A comparative evaluation of culture and PCR for the detection and determination of persistence of bacterial strains and DNAs in the Chinchilla laniger model of otitis media
17. Bacterial biofilms: A common cause of persistent infections
18. The biofilm glycocalyx as a resistance factor
19. Introduction to biofilm
20. How bacteria stick
21. Direct confocal microscopy studies of the bacterial colonization in vitro of a silver-coated heart valve sewing cuff
22. Effect of nutrients on defined bacterial plaques and Streptococcus mutans C67-1 implantation in a model mouth
23. The pathobiology of periodontal diseases may affect systemic diseases: Inversion of a paradigm
24. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
25. Cystic fibrosis pathogenesis and the role of biofilms in persistent infection
26. Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth
27. Depth penetration and detection of pH gradients in biofilms by two-photon excitation microscopy
28. Individual-based modelling of biofilms
29. Is there a synergistic effect between mixed bacterial infection in biofilm formation on biliary stents?
30. Microbial biofilms
31. Distribution of bacterial growth activity in flow-chamber biofilms
32. Flow cytometry and other techniques show that Staphylococcus aureus undergoes significant physiological changes in the early stages of surface-attached culture
33. Quorum sensing signals in development of Pseudomonas aeruginosa biofilms
34. Acyl-homoserine lactone quorum sensing in gram-negative bacteria: A signaling mechanism involved in associations with higher organisms
35. Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa
36. Quorum sensing in bacteria
37. Heterogeneity in biofilms
38. Sessile bacteria: An important component of the microbial population in small mountain streams
39. Detection of differential gene expression in biofilm-forming versus planktonic populations of Staphylococcus aureus using micro-representational-difference analysis
40. Gene expression in Pseudomonas aeruginosa biofilms
41. Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm
42. Effectiveness of adenoidectomy and tympanostomy tubes in the treatment of chronic otitis media with effusion
43. Spontaneous resolution of severe chronic glue ear in children and the effect of adenoidectomy, tonsillectomy, and insertion of ventilation tubes (grommets)