Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 52, Issue 2, 1997, Pages 144-154

  Oehling, A G ^a,b   Akdis, C A ^a   Schapowal, A ^b   Blaser, K ^a   Schmitz, M ^b   Simon, H U ^a,c  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Hochgebirgsklinik Davos Wolfgang   (Switzerland)

^c SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

Author keywords

Asthma; Cytofluorometric analysis; Cytokines; Glucocorticoids; Immune monitoring; Immunosuppression; Inflammation

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; DEXAMETHASONE; GLUCOCORTICOID; HLA DR ANTIGEN; IMMUNOGLOBULIN E; PREDNISONE;

ADULT; ARTICLE; ASTHMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; MAJOR CLINICAL STUDY; MONOCYTE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; RISK; T LYMPHOCYTE SUBPOPULATION;

EID: 0030890589     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1398-9995.1997.tb00968.x     Document Type: Article

References (44)

1. Azzawi M, Bradley B, Jeffery PK, et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990;142:1407-13.
2. Bentley AM, Hamid Q, Robinson DS, et al. Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modula-tion of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am J Respir Crit Care Med 1996;153:551-6.
3. Corrigan CJ, Brown PH, Barnes NC, et al. Glucocorticoid resistance in chronic asthma: glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics and inhibition of peripheral blood T-cell proliferation by glucocorticoids in vitro. Am Rev Respir Dis 1991;144: 1016-25.
4. Corrigan CJ, Hamid Q, North J, et al. Peripheral blood CD4 but not CD8 T-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy. Am J Respir Cell Mol Biol 1995;147:567-78.
5. + T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol 1994;10:587-93.
6. Leung DYM, Martin RJ, Szefler SJ, et al. Dysregulation of interleukin 4, interleukin 5, and interferon-γ gene expression in steroid-resistant asthma. J Exp Med 1995;181:33-40.
7. Montano E, Schmitz M, Blaser K, Simon HU. P-glycoprotein expression in circulating blood leukocytes of patients with steroid-resistant asthma. Invest Allergol Clin Immunol 1996;6:14-21.
8. Robinson D, Hamid Q, Ying S, et al. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-γ cytokine gene expression. Am Rev Respir Dis 1993;148:401-6.
9. Simon HU, Blaser K. Inhibition of programmed eosinophil death - a key pathogenic event for eosinophilia? Immunol Today 1995;16:53-5.
10. Simon HU, Grotzer M, Nikolaizik WH, Blaser K, Schöni MH. High altitude climate therapy reduces peripheral blood T lymphocyte activation, eosinophilia, and bronchial obstruction in children with house-dust mite allergic asthma. Pediatr Pulmonol 1994;17:304-11.
11. Simon HU, Tsao PW, Siminovitch KA, Mills GB, Blaser K. Functional platelet-activating factor receptors are expressed by monocytes and granulocytes but not by resting or activated T and B lymphocytes from normal individuals or patients with asthma. J Immunol 1994;153: 364-77.
12. Walker C, Virchow JC, Bruijnzeel PLB, Blaser K. T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma. J Immunol 1991;146: 1829-35.
13. + subsets. J Immunol 1995;155:3322-8.
14. Byron KA, Varigos G, Wootton A. Hydrocortisone inhibition of human interleukin-4. Immunology 1992;77: 624-6.
15. Okayama H, Fushimi T, Shimura S, Sasaki H, Shirato K. Glucocorticoids suppressed production and gene expression of interleukin-5 by peripheral blood mononuclear cells in atopic patients and normal subjects. J Allergy Clin Immunol 1994;93:1006-12.
16. Rolfe FG, Hughes JM, Armour CL, Sewell WA. Inhibition of interleukin-5 gene expression by dexamethasone. Immunology 1992;77:494-9.
17. Wu C, Fargeas Y, Nakajiama Y, Delespesse G. Glucocorticoids suppress the production of interleukin 4 by human lymphocytes. Eur J Immunol 1991;21:2645-7.
18. Dale DC, Fauci AS, Wolff SM. Alternate-day prednisone. Leukocyte kinetics and susceptibility to infections. N Engl J Med 1974;291:1154-8.
19. International Consensus Report on Diagnosis and Treatment of Asthma, 1992. National Heart, Lung, and Blood Institute. NIH Publication no. 92-3091, National Institutes of Health, Bethesda, MD.
20. - T cells associated with abnormal Fas expression and hypereosinophilia. J Exp Med 1996;183:1071-82.
21. Yousefi S, Green DR, Blaser K, Simon HU. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc Natl Acad Sci USA 1994;91:10868-72.
22. Yousefi S, Hoessli DC, Blaser K, Mills GB, Simon HU. Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J Exp Med 1996;183:1407-14.
23. Arya SK, Wong-Staal F, Gallo RC. Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA. J Immunol 1984;133: 273-9.
24. Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 1993;259: 1739-42.
25. Reinke P, Volk HD. Diagnostic and predictive value of an immune monitoring program for complications after kidney transplantation. Urol Int 1992;49:69-75.
26. Hershman MJ, Appel SH, Wellhausen SR, Sonnenfeld G, Polck HC Jr. Interferon-γ treatment increases HLA-DR expression on monocytes in severely injured patients. Clin Exp Immunol 1989;77:67-70.
27. Griggs RC, Condemi JJ, Vaughan JH. Effect of therapeutic dosages of prednisone on human immunoglobulin G metabolism. J Allergy Clin Immunol 1972;49:267-73.
28. Hamilos DL, Young RM, Peter JB, Agopian MS, Ilké DN, Barka N. Hypogammaglobulinemia in asthmatic patients. Ann Allergy 1992;68:472-81.
29. Posey WC, Nelson HS, Branch B, Pearlman DS. The effects of acute corticosteroid therapy for asthma on serum immunoglobulin levels. J Allergy Clin Immunol 1978;62: 340-8.
30. Utiger RD. Differences between inhaled and oral glucocorticoid therapy. N Engl J Med 1993;329:1731-3.
31. Anderson RJ, Schaffer LA, Olin DB, Eickhoff TC. Infectious risk factors in the immunosuppressed host. Am J Med 1973;54:453-60.
32. Bach MC, Sahyoun A, Adler JL, et al. Influence of rejection therapy on fungal and nocardial infections in renal-transplant recipients. Lancet 1973;1:180-4.
33. Farr RW. Pneumocystis carinii pneumonia due to corticosteroids. South Med J 1992;85:52-3.
34. Krussmann A, Goerg R, Laberke HG, Weidner FO. Extensive metastatic Kaposi sarcoma in chronic immune suppressed bronchial asthma. Hautarzt 1993;44:232-4.
35. Kuitert LM, Harrison AC. Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma. Thorax 1991;46:936-7.
36. Welch MJ. Inhaled steroids and severe viral infections. J Asthma 1994;31:43-50.
37. Butler WT, Rossen RD. Effects of corticosteroids on immunity in man. J Clin Invest 1973;52:2629-40.
38. Krammer PH, Behrmann I, Daniel P, Dhein J, Debatin KM. Regulation of apoptosis in the immune system. Curr Opin Immunol 1994;6:279-89.
39. Perandones CE, Illera VA, Peckham D, Stunz LL, Ashman RF. Regulation of apoptosis in vitro in mature murine spleen T cells. J Immunol 1993;151:3521-9.
40. Tuosto L, Cundari E, Montani MSG, Piccolella E. Analysis of susceptibility of mature human T lymphocytes to dexamethason-induced apoptosis. Eur J Immunol 1994;24: 1061-5.
41. Walzer PD, LaBine M, Redington TJ, Cushion MT. Lymphocyte changes during chronic administration of and withdrawal from corticosteroids: relation to Pneumocystis carinii pneumonia. J Immunol 1984;133:2502-8.
42. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 1995;270:286-90.
43. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 1995;270: 283-6.
44. Levy J, Zalkinder I, Kuperman O, et al. Effect of prolonged use of inhaled steroids on the cellular immunity of children with asthma. J Allergy Clin Immunol 1995;95: 806-12.