Hypoglycemic agent YM440 suppresses hepatic glucose output via gluconeogenesis by reducing glucose-6-phosphatase activity in obese Zucker rats

European Journal of Pharmacology

Volumn 468, Issue 2, 2003, Pages 151-158

  Kurosaki, Eiji ^a   Nakano, Ryosuke ^a   Momose, Kazuhiro ^a   Shimaya, Akiyoshi ^a   Suzuki, Takayuki ^a   Shibasaki, Masayuki ^a   Shikama, Hisataka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Fructose 1,6 bisphosphatase; Gluconeogenesis; Glucose output; Glucose, blood; Glucose 6 phosphatase; Hepatic; YM440

Indexed keywords

1,4 BIS[4 [(3,5 DIOXO 1,2,4 OXADIAZOLIDIN 2 YL)METHYL]PHENOXY]BUT 3 ENE; ANTIDIABETIC AGENT; BICARBONATE; CARBON 14; FRUCTOSE BISPHOSPHATASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; OXAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG; YM 440;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME REPRESSION; FEEDING; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; LIVER METABOLISM; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; REGULATORY MECHANISM;

EID: 0037720326     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)01670-4     Document Type: Article

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