Dehydroepiandrosterone suppresses the elevated hepatic glucose-6- phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: Comparison with troglitazone

Diabetes

Volumn 48, Issue 8, 1999, Pages 1579-1585

  Aoki, Kazutaka ^a   Saito, Tatsuya ^a   Satoh, Shinobu ^a   Mukasa, Koji ^a   Kaneshiro, Mizuki ^a   Kawasaki, Satsuki ^a   Okamura, Atsushi ^a   Sekihara, Hisahiko ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSE BISPHOSPHATASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; INSULIN; PRASTERONE; TROGLITAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANDROSTENEDIONE; ANIMALS; BLOOD GLUCOSE; BODY COMPOSITION; CHROMANS; DEHYDROEPIANDROSTERONE; DIABETES MELLITUS; EATING; FRUCTOSE-BISPHOSPHATASE; GLUCOSE-6-PHOSPHATASE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; THIAZOLES; THIAZOLIDINEDIONES;

EID: 0032768942     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.8.1579     Document Type: Article

References (34)

1. Gunnarsson R: Function of the pancreatic B-cell during the development of hyperglycemia in mice homozygous for the mutations "diabetes" (db) and "misty" (m). Diabetologia 11:431-438, 1975
2. Coleman DL, Leiter EH, Schwizer RW: Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice. Diabetes 31:830-833, 1982
3. Coleman DL, Schwizer RW, Leiter EH: Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and aged normal mice. Diabetes 33:26-32, 1984
4. Mohan PF, Cleary MP: Effect of short term DHEA administration on liver metabolism of lean and obese rats. Am J Physiol 255:E1-E8, 1988
5. Mohan PF, Cleary MP: Dehydroepiandrosterone and related steroids inhibit mitochondrial respiration in vitro. Int J Biochem 21:1103-1107, 1989
6. Cleary MP: Effect of dehydroepiandrosterone treatment on liver metabolism in rats. Int J Biochem 22:205-210, 1990
7. Mohan PF, Cleary MP: Short-term effects of dehydroepiandrosterone treatment in rats on mitochondrial respiration. J Nutr 121:240-250, 1991
8. Cleary MP: The antiobesity effect of dehydroepiandrosterone in rats. Proc Soc Exp Biol Med 196:8-16, 1991
9. McIntosh MK, Berdanier CD: Antiobesity effects of dehydroepiandrosterone are mediated by futile substrate cycling in hepatocytes of BHE/cbd rats. J Nutr 121:2037-2043, 1991
10. Berdanier CD, McIntosh MK: Further studies on the effects dehydroepiandrosterone of hepatic metabolism in BHE rats. Proc Soc Exp Biol Med 192:242-247, 1989
11. Ladriere L, Laghmich A, Malaisse-Lagae F, Malaisse WJ: Effect of dehydroepiandrosterone in hereditarily diabetic rats. Cell Biochem Funct 15:287-292, 1997
12. Kimura M, Tanaka S, Yamada Y, Kikuchi Y, YamakawaT, Sekihara H: Dehydroepiandrosterone decreases serum TNF α and restores insulin sensitivity: independent effect from secondary weight reduction in genetically obese Zucker fatty rats. Endocrinology 139:3249-3253, 1998
13. Mukasa K, Kaneshiro M, Aoki K, Okamura J, Saito T, Satoh S, Sekihara H: Dehydroepiandrosterone (DHEA) ameliorates the insulin sensitivity in older rats. J Steroid Biochem Mol Biol 67:355-358, 1998
14. Fujiwara T, Okuno A, Yoshioka S, Horikoshi H: Suppression of hepatic gluconeogenesis in long-term troglitazone treated diabetic KK and C57BL/KsJ-db/db mice. Metabolism 44:486-490, 1995
15. Pilkis SJ: Glucokinase of rat liver. Methods Enzymol 42:31-39, 1975
16. Kemp RG: Phosphofructokinase from rabbit liver. Methods Enzymol 42: 67-71, 1975
17. Blair JB, Cimbala MA, Foster JL, Morgan RA: Hepatic pyruvate kinase. J Biol Chem 251:3756-3762, 1976
18. Ulm EH, Pogell BM, De Maine MM, Libby CB, Benkovic SJ: Fructose-1,6-diphosphatase from rabbit liver. Methods Enzymol 42:369-374, 1975
19. Colombo G, Carlson GM, Lardy HA: Phosphoenolpyruvate carboxykinase (guanosine triphosphate) from rat liver cytosol: separation of homogeneous forms of the enzyme with high and low activity by chromatography on agarose-hexane-guanosine triphosphate. Biochemistry 17:5321-5329, 1978
20. Gierow P, Jergil B: Spectrophotometric method for glucose-6-phosphate phosphatase. Methods Enzymol 89:44-47, 1982
21. Pilkis SJ, Granner DK: Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 54:885-909, 1992
22. Chang AY, Schneider DI: Abnormalities in hepatic enzyme activities during development of diabetes in db mice. Diabetotogia 6:274-278, 1970
23. Chan TM, Young KM, Hutson NJ, Brumley FT, Exton JH: Hepatic metabolism of genetically diabetic (db/db) mice. I. Carbohydrate metabolism. Am J Physiol 229:1702-1711, 1975
24. Kodama H, Fujita M, Yamazaki M, Yamaguchi I: The possible role of age-related increase in the plasma glucagon/insulin ratio in the enhanced hepatic gluconeogenesis and hyperglycemia in genetically diabetic (C57BL/KsJ-db/db) mice. Jpn J Pharmacol 66:281-287, 1994
25. Hotta K, Kawajima M, Ono A, Nakajima H, Shingu R, Miyagawa J, Namba M, Hanafusa T, Noguchi T, Kono N, Matsuzawa Y: Disordered expression of hepatic glycolytic and gluconeogenic enzymes in Otsuka Long-Evans Tokushima fatty rats with spontaneous long-term hyperglycemia. Biochim Biophys Acta 1289:145-149, 1996
26. Mayer D, Weber E, Moore MA, Letsch I, Filsinger E, Bannasch P: Dehydroepiandrosterone induced alternations in rat liver carbohydrate metabolism. Carcinogenesis 9:2039-2043, 1988
27. Lee MK, Miles PD, Khoursheed M, Gao KM, Moossa AR, Olefsky JM: Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes 43:1435-1439, 1994
28. Fulgencio JP, Kohl C, Girard J, Pegorier JP: Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats. Diabetes 45:1556-1562, 1996
29. Raman P, Foster SE, Stokes MC, Strenge JK, Judd RL: Effect of troglitazone (Rezulin) on fructose 2,6-bisphosphate concentration and glucose metabolism in isolated rat hepatocytes. Life Sci 62:89-94, 1998
30. Suter SL, Nolan JJ, Wallace P, Gumbiner B, Olefsky JM: Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care 15: 193-203, 1992
31. Maggs DG, Buchanan TA, Burant CF, Cline G, Gumbiner B, Hsueh WA, Inzucchi S, Kelley D, Nolan J, Olefsky JM, Polonsky KS, Silver D, Valiquett TR, Shulman GI: Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 128:176-185, 1998
32. Inzucchi SE, Maggs DG, Spollett GR, Page SL, Rife FS, Walton V, Shulman GI: Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. N Engl J Med 338:867-872, 1998
33. van Weerden WM, Bierings HG, van Steenbrugge GJ, de Jong FH, Scroder FH: Adrenal gland of mouse and rat do not synthesize androgens. Life Sci 50: 857-861, 1992
34. Yamaguchi Y, Tanaka S, Yamakawa T, Kimura M, Ukawa K, Yamada Y, Ishihara M, Sekihara H: Reduced serum dehydroepiandrosterone levels in diabetic patients with hyperinsulinemia. Clin Endocrinol 49:377-383, 1998