Immunotoxicity of epicutaneously applied anticoagulant rodenticide warfarin: Evaluation by contact hypersensitivity to DNCB in rats

Toxicology

Volumn 188, Issue 1, 2003, Pages 83-100

  Kataranovski, Milena ^a   Vlaški, Marija ^b   Kataranovski, Dragan ^b   Tošić, Nataša ^b   Mandić Radić, Slavka ^a   Todorović, Vera ^c  

^a UNIVERSITY OF DEFENCE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Contact hypersensitivity; DA rats; Draining lymph nodes; Immunotoxicity; Peripheral blood granulocytes; Warfarin

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; ANTICOAGULANT AGENT; HAPTEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; RODENTICIDE; WARFARIN;

ALLERGY TEST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL ADHESION; CELL FUNCTION; CELL PROLIFERATION; CELL STIMULATION; CELL TYPE; CELL VIABILITY; CIRCULATION; CONTACT ALLERGY; CONTACT SENSITIZATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GRANULOCYTE; IMMUNOLOGICAL PROCEDURES; IMMUNOSTIMULATION; IMMUNOTOXICITY; LYMPH NODE; LYMPH NODE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; T LYMPHOCYTE;

EID: 0037718302     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(03)00047-7     Document Type: Article

References (63)

1. Abell T.L., Merigian K.S., Lee J.M., Holbert J.M., McCall J.W. Cutaneous exposure to WF-like anticoagulant causing an intracerebral hemorrhage: a case report. Clin. Toxicol. 32:1994;69-73.
2. Avanzi G.C., Gallicchio M., Bottarel F., Gammaitoni L., Cavalloni G., Buonfiglio D., Bragardo M., Bellomo G., Albano E., Fantozzi R., Garbarino G., Va-rnum B., Aglietta M., Saglio G., Dianzani U., Dianzani C. GAS6 inhibits granulocyte adhesion to endothelial cells. Blood. 91:1998;2334-2340.
3. Barone L.M., Aronow M.A., Tassinari M.S., Colon D., Canalis E., Stein G.S., Lian J.B. Differential effects of WF on mRNA levels of developmentally regulated vitamin K dependent proteins, osteocalcin, and matrix GLA protein in vitro. J. Cell. Physiol. 160:1994;255-264.
4. Berkner K. The vitamin K-dependent carboxylase. J. Nutr. 130:2000;1800-1877.
5. Berridge M.V., Tan A.S. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Arch. Biochem. Biophys. 303:1993;474-482.
6. Berridge M.V., Horsfield J.A., Tan A.S. Evidence that cell survival is controlled by interleukin-3 independently of cell proliferation. J. Cell. Physiol. 163:1994;474-482.
7. Berridge M.V., Tan A.S., McCoy K.D., Wang R. The biochemical and cellular basis of cell proliferation assay that use tetrazolium salts. Biochemica. 4:1996;15-20.
8. Blaylock B.L., Kouchi Y., Comment C.E., Pollock P.L., Luster M.I. Topical application of T-2 toxin inhibits the contact hypersensitivity response in BALB/c mice. J. Immunol. 150:1993;5135-5143.
9. Bruserud O. The additive effect of certain drugs on the cyclosporine A inhibition of human T-cell proliferation. Studies using theophyllamine, warfarin, verapamil and dipyridamol. APMIS. 98:1990;1070-1076.
10. Bruserud O., Lundin K. The effect of drugs used in anticoagulation therapy on T lymphocyte activation in vitro. II. Warfarin inhibits T lymphocyte activation. J. Clin. Lab. Immunol. 23:1987;169-173.
11. Chan J.C.Y.C., Ganopolsky J.G., Cornelissen I., Suckow M.A., SandovalCooper M.J., Brown E.C., Noria F., Gailani D., Rosen E.D., Ploplis V.A., Castellino F.J. The characterization of mice with a targeted combined deficiency of protein C and factor XI. Am. J. Pathol. 158:2001;469-479.
12. Daniels R.H., Elmore M.A., Hill M.E., Shimizu Y., Lackie J.M., Finnen M.J. Priming of the oxidative burst in human neutrophils by physiological agonist or cytochalasin B results from the recruitment of previously nonresponsive cells. Immunology. 82:1994;465-472.
13. DiPalma J.R. Human toxicity form rat poisons. Am. Fam. Phys. 24:1981;186-189.
14. Eby S. Warfarin-induced skin necrosis. Hematol./Oncol. Clin. North Am. 1:1993;1291-1299.
15. Environmental Health Criteria Series. 1995. Anticoagulant rodenticides. No 175, WHO, pp. 121.
16. Farrar A., Cabral R. Recent epidemics of poisoning by pesticides. Toxicol. Lett. 82/83:1995;55-63.
17. Friested B., Sterner N. Warfarin intoxication from percutaneous absorption. Arch. Environ. Health. 11:1965;205-208.
18. Furie B. Oral anticoagulant therapy. Hoffman R., Benz E.J., Shatill S.J., Furie B., Cohen J.H., Silberstein L.E., McGlave P. Hematology. Basic Principle and Practice. 2000;2040-2046 Churchill Livingstone. A Harcourt Health Science Company.
19. Grey S.T., Tsuchida A., Hau H., Orthner C.L., Salem H.H., Hancock W.W. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma or phorbol ester. J. Immunol. 153:1994;3664-3672.
20. Hancock W.W., Tsuchida A., Hau H., Thomson N.M., Salem H.H. The anticoagulants protein C and protein S display potent antiinflammatory and immunosuppressive effects relevant to transplant biology and therapy. Transplant Proc. 24:1992;2302-2303.
21. Hermes B., Haas N., Henz B.M. Immunopathological events of adverse cutaneous reactions to coumarin and heparin. Acta Derm. Venerol. 77:1997;35-38.
22. Hope J., Dearman R.J., Debicki R.J., Kimber I., Hopkins S.J. Interleukin-6 production by draining lymph node cells following primary contact sensitization of mice: relationship to the proliferative response. Int. Arch. Allergy Immunol. 103:1994;378-383.
23. Hope J., Campbell F., Hopkins S.J. Deficiency of IL-2 or IL-6 reduces lymphocyte proliferation but only IL-6 deficiency decreases the contact hypersensitivity response. Eur. J. Immunol. 30:2000;197-203.
24. Huckle K.R., Morrison B.J., Warburton P.A. The percutaneous fate of the rodenticide flocoumafen in the rat: role of non-biliary intestinal excretion. Xenobiotica. 19:1989;63-74.
25. Jabbar S.A.B., Twentyman P.R., Watson J.V. The MTT assay underestimates the growth inhibitory effects of interferons. Br. J. Cancer. 60:1989;523-528.
26. Kataranovski D.S., Kataranovski M., Ivanovic I., Mandic-Radic S., Stupar V., Dujic A. The toxicity of rodenticides following topical application. I. LD50 and LD100.values and changes of selected serum and urine biochemical parameters. J. Serb. Chem. Soc. 59:1994;787-795.
27. Kataranovski M., Kataranovski D.S., Jovcic G., Stojanovic N., Dujic A. The toxicity of rodenticides in rats following topical application. II. Immunosuppressive effects of rodenticides. J. Serb. Chem. Soc. 59:1994;797-801.
28. Kataranovski M., Draškovic-Pavlovic B., Jovcic G., Milojevic G., Todorovic V., Colic M., Popovic P. Peripheral blood granulocyte activity following contact sensitization of rats with dinitrochlorobenzene. Toxicology. 162:2001;121-136.
29. Kataranovski M., Kandolf-Sekulovic L., Karadaglic Dj. Experimental contact sensitivity: a model for both antigen (hapten)-specific and innate immune mechanisms. Acta Dermatovenerol. Alp. Panonica Adriat. 10:2001;85-91.
30. Kawabata T.T., Burleson G.R., Ernst P.B., Ullrich S.E. Immunotoxicology of regional lymphoid tissue: the respiratory and gastrointestinal tracts and skin. Fundam. Appl. Toxicol. 26:1995;8-19.
31. Kawaii S., Tomono Y., Ogawa K., Sugiura M., Yano M., Yoshizawa Y. The antiproliferative effect of coumarins on several cancer cell lines. Anticancer Res. 21:2001;917-923.
32. Kimber I., Cumberbattch M., Humphreys M., Hopkins S.J. Contact hypersensitivity induces plasma interleukin-6. Int. Arch. Allergy Appl. Immunol. 92:1990;97-99.
33. Kulman J.D., Harris J.E., Haldeman B.A., Davie E.W. Primary structure and tissue distribution of two novel proline rich γ-carboxyglutamic acid proteins. Proc. Natl. Acad. Sci. USA. 94:1997;9058-9062.
34. Kulman J.D., Harris J.E., Xie L., Davie E.W. Identification of two novel transmembrane γ-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. Proc. Natl. Acad. Sci. USA. 98:2001;1370-1375.
35. Laruelle C., Godfroid J.J. Quantitative structure-activity relationship for dicoumarol antivitamins K in the uncoupling of mitochondrial oxidative phosphorylation. J. Med. Chem. 18:1975;85-90.
36. Lund M. Anticoagulant rodenticides. Prakash I. Rodent Pest Management. 1988;341-351 CRC Press, Boca Raton, FL.
37. Mach N., Lantz S., Galli S.J., Reznikoff G., Mihm M., Small C., Granstein R., Beissert S., Sadelain M., Mulligan R.C., Dranof G. Involvement of interleukin-3 in delayed-type hypersensitivity. Blood. 91:1998;778-783.
38. Manfioletti G., Brancolini C., Avanzi G., Schneider C. The protein enco-ded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S a negative coregulator in the blood coagulation cascade. Mol. Cell. Biol. 13:1993;4976-4985.
39. Martin-Boyer G., Khanh N.B., Linh P.H. Epidemic of hemorrhagic disease in Vietnamese infants caused by warfarin-containing talcs. Lancet. 1:1983;230-232.
40. McNiel N.O., Morgan L.R. Effects of sodium warfarin and sodium heparin plus anticancer agents on growth of rat C6 glioma cells. J. Natl. Cancer Inst. 73:1984;169-176.
41. Mizutani A., Okajima K., Uchiba M., Noguchi T. Activated protein C reduces ishemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood. 95:2000;3781-3787.
42. Mohler K.M., Butler L.D. Quantification of cytokine mRNA levels utilizing the reverse transcriptase polymerase chain reaction following primary sensitization in vivo: verification of linearity reproducibility and specificity. Mol. Immunol. 28:1991;437-447.
43. 2 integrin. J. Leukocyte Biol. 50:1991;373-380.
44. Mosmann T.J. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Immunol. Methods. 65:1983;55-63.
45. Murakami K., Okajima K., Johno M., Nakagaki T., Okabe H., Takatsuki K. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood. 87:1996;642-647.
46. Nakano T., Kawamoto K., Kishino J., Nomura K., Higashino K., Arita H. Requirement of gamma-carboxyglutamic acid residues for the biological activity of Gas6: contribution of endogenous Gas6 to the proliferation of vascular smooth cells. Biochem. J. 323:1997;387-392.
47. Oez S., Welte K., Platzer E. A quantitative colorimetric method to evaluate the functional state of human polymorphonuclear leukocytes. Blut. 60:1990;97-102.
48. Oez S., Welte K., Platzer E., Kalden J.R. A simple assay for quantifying the inducible adherence of neutrophils. Immunobiology. 180:1990;308-315.
49. Pavlović, M.D., Čolić, M., Pejnović, N., Tamatani, T., Miyasaka, M., Dujić, A. 1994. A novel anti-rat CD 18 monoclonal antibody triggers lymphocyte homotypic aggregation and granulocyte adhesion to plastic: different intracellular signalling pathways in resting versus activated thymocytes. Eur. J. Immunol. 24 1640-1648.
50. Pratt S.K., Winn M.J., Park B.K. The disposition of the enantiomers of warfarin following chronic administration to rats: relationship to anticoagulant response. J. Pharmacol. 41:1989;743-746.
51. Price P.A. Role of vitamin K-dependent-dependent proteins in bone metabolism. Anu. Rev. Nutr. 8:1988;565-583.
52. Robinson M.K. Optimization of an in vitro lymphocyte blastogenesis assay for predicitive assessment of immunological responsiveness to contact sensitizers. J. Invest. Dermatol. 92:1989;860-867.
53. Shearer M.J. Vitamin K and vitamin K-dependent proteins. Br. J. Haematol. 75:1990;156-162.
54. Shibata M., Ram Kumar S., Amar A., Fernandez J.A., Hofman F., Griffin J.H., Zlokovic B.V. Anti-inflammatory, antithrombotic and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 103:2001;1799-1805.
55. Shimada H., Hirai K., Simamura E., Pan J. Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat livers. Arch. Biochem. Biophys. 351:1998;75-81.
56. Storm J.E., Collier R.F., Stewart R.F., Bronaugh R.L. Metabolism of xenobiotics during percutaneous penetration: role of absorption rate and cutaneous enzyme activity. Fundam. Appl. Toxicol. 15:1990;132-141.
57. Sunnerhagen M., Drakenberg T., Forsen S., Stenflo J. Effect of Ca++ on the structure of vitamin K-dependent coagulation factors. Haemostasis. 26:1996;45-53.
58. Taylor F., Chang G., Ferrell G., Mather T., Catlett R., Blick K., Esmon C.T. C4b-binding protein exacerbates the host response to Escherichia coli. Blood. 78:1991;357-363.
59. Taylor F.B. Jr, Stearns-Kurosawa D.J., Kurosawa S., Ferrell G., Chang C.K., Laszik S., Kosanke S., Peer G., Esmon C.T. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Hemost. Thromb. Vasc. Biol. 95:2000;1680-1686.
60. Teodorczyk-Injeyan J.A., Sparkes B.G., Mills G.B., Falk R.E., Peters W.J. Increase of serum interleukin-2 receptor level in thermally injured patients. Clin. Immunol. Immunopathol. 51:1989;205-215.
61. Tokunaga F., Wakabayashi S., Koide T. Warfarin causes the degradation of protein C precursor in the endoplasmic reticulum. Biochemistry. 34:1995;1163-1170.
62. Yanagita M., Ishii K., Ozaki H., Arai H., Nakano T., Ohashi K., Mizuno K., Kita T., Doi T. Mechanism of inhibitory effect of warfarin on mesangial cell proliferation. J. Am. Soc. Nephrol. 10:1999;2503-2509.
63. Yourick J.J., Bronaugh R.L. Percutaneous absorption and metabolism of coumarin in human and rat skin. J. Appl. Toxicol. 17:1997;153-158.