Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic background

Annals of the New York Academy of Sciences

Volumn 994, Issue , 2003, Pages 202-210

  Smart, James L ^a   Low, Malcolm J ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Adrenal; Corticosterone; Hypothalamic pituitary adrenal axis (HPA); Obesity; Pigmentation; Proopiomelanocortin (POMC)

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; CORTICOTROPIN; GLUCOCORTICOID; PEPTIDE DERIVATIVE; PROOPIOMELANOCORTIN;

ADOLESCENT; ADRENAL CORTEX ATROPHY; ADRENAL DISEASE; ANIMAL TISSUE; BODY GROWTH; CONFERENCE PAPER; CORTICOSTEROID RELEASE; CORTICOSTERONE BLOOD LEVEL; DIET SUPPLEMENTATION; FEMALE; GENE MUTATION; GENETICS; HAIR COLOR; HOMOZYGOTE; HORMONAL THERAPY; HORMONE DEFICIENCY; MALE; MELANOCYTE; MOUSE; MOUSE STRAIN; NEWBORN; NONHUMAN; OBESITY; PERINATAL MORTALITY; PHENOTYPE; PIGMENTATION; STEROIDOGENESIS; STRESS; TREATMENT FAILURE;

AGOUTI; ANIMALIA; MURINAE;

EID: 0037713246     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb03181.x     Document Type: Conference Paper

References (22)

1. ELMQUIST, J.K., C.F. ELIAS & C.B. SAPER. 1999. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22: 221-232.
2. TATRO, J.B. 1990. Melanotropin receptors in the brain are differentially distributed and recognize both corticotropin and alpha-melanocyte stimulating hormone. Brain Res. 536: 124-132.
3. HUSZAR, D. et al. 1997. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88: 131-141.
4. BUTLER, A.A. et al. 2000. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141: 3518-3521.
5. CHEN, A.S. et al. 2000. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat. Genet. 26: 97-102.
6. APPLEYARD, S.M. et al. 2003. A role for the endogenous opioid β-endorphin in energy homeostasis. Endocrinology 144: 1753-1760.
7. HAYWARD, M.D., J.E. PINTAR & M.J. LOW. 2002. Selective reward deficit in mice lacking beta-endorphin and enkephalin. J. Neurosci. 22: 8251-8258.
8. ALLEN, R.G. et al. 1984. Biosynthesis and processing of pro-opiomelanocortin-derived peptides during fetal pituitary development. Dev. Biol. 102: 43-50.
9. BERRY, S. & L.W. HAYNES. 1989. The opiomelanocortin peptide family: neuronal expression and modulation of neural cellular development and regeneration in the central nervous system. Comp. Biochem. Physiol. A 93: 267-272.
10. BICKNELL, A.B. et al. 2001. Characterization of a serine protease that cleaves pro-gamma-melanotropin at the adrenal to stimulate growth. Cell 105: 903-912.
11. ESTIVARIZ, F.E. et al. 1988. Adrenal regeneration in the rat is mediated by mitogenic N-terminal pro-opiomelanocortin peptides generated by changes in precursor processing in the anterior pituitary. J. Endocrinol. 116: 207-216.
12. ESTIVARIZ, F.E. et al. 1988. Further evidence that N-terminal pro-opiomelanocortin peptides are involved in adrenal mitogenesis. J. Endocrinol. 116: 201-206.
13. MARSH, D.J. et al. 1999. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat. Genet. 21: 119-122.
14. ZAGON, I.S. & P.J. MCLAUGHLIN. 1987. Endogenous opioid systems regulate cell proliferation in the developing rat brain. Brain Res. 412: 68-72.
15. YASWEN, L. et al. 1999. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat. Med. 5: 1066-1070.
16. BOSTON, B.A. et al. 1997. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 278: 1641-1644.
17. MUGLIA, L. et al. 1995. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 373: 427-432.
18. OLLMANN, M.M. et al. 1998. Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev. 12: 316-330.
19. COWLEY, M.A. et al. 2001. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411: 480-484.
20. ELIAS, C.F. et al. 1998. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21: 1375-1385.
21. BUTLER, A.A. & R.D. CONE. 2002. The melanocortin receptors: lessons from knockout models. Neuropeptides 36: 77-84.
22. KOZAK, L.P. & M. ROSSMEISL. 2002. Adiposity and the development of diabetes in mouse genetic models. Ann. N.Y. Acad. Sci. 967: 80-87.