Rosiglitazone reverses insulin secretion altered by chronic exposure to free fatty acid via IRS-2-associated phosphatidylinositol 3-kinase pathway

Acta Pharmacologica Sinica

Volumn 24, Issue 5, 2003, Pages 429-434+478

  Yuan, Li ^a   An, Han Xiang ^b   Deng, Xiu Ling ^a   Chen, Lu Lu ^a   Li, Zhuo Ya ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

1 phosphatidynositol 3 kinase; Fatty acid; Insulin; Rosiglitazone; Signal transduction

Indexed keywords

FATTY ACID; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; OLEIC ACID; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; ROSIGLITAZONE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME SUBUNIT; IMMUNOPRECIPITATION; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; FATTY ACIDS; HYPOGLYCEMIC AGENTS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; MALE; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; THIAZOLES; THIAZOLIDINEDIONES;

EID: 0037693962     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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