Cdc42 and Rac small G proteins activated by trans-interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts

Genes to Cells

Volumn 8, Issue 5, 2003, Pages 481-491

  Honda, Tomoyuki ^a   Shimizu, Kazuya ^a   Kawakatsu, Tomomi ^a   Fukuhara, Atsunori ^a   Irie, Kenji ^a   Nakamura, Takeshi ^b   Matsuda, Michiyuki ^b   Takai, Yoshimi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CADHERIN; CELL ADHESION MOLECULE; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN CDC42; RAC PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL JUNCTION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; EPITHELIUM CELL; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADHERENS JUNCTIONS; ANDROSTADIENES; ANIMALS; CADHERINS; CDC42 GTP-BINDING PROTEIN; CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE; ENZYME INHIBITORS; FIBROBLASTS; GREEN FLUORESCENT PROTEINS; IMAGE PROCESSING, COMPUTER-ASSISTED; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUMINESCENT PROTEINS; MICE; MICROSCOPY, ELECTRON, SCANNING; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PSEUDOPODIA; RAC GTP-BINDING PROTEINS; TRANSFECTION;

ANIMALIA;

EID: 0037689074     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2003.00649.x     Document Type: Article

References (50)

1. Asada, M., Irie, K., Morimoto, K., et al. (2003) ADIP: a novel afadin- and α-actinin-binding protein localized at cell-cell adherens junctions. J. Biol. Chem. 278, 4103-4111.
2. Asakura, T., Nakanishi, H., Sakisaka, T., et al. (1999) Similar and differential behaviour between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells. Genes Cells 4, 573-581.
3. Bagrodia, S., Derijard, B., Davis, R.J. & Cerione, R.A. (1995) Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270, 27995-27998.
4. Betson, M., Lozano, E., Zhang, J. & Braga, V.M.M. (2002) Rac activation upon cell-cell contact formation is dependent on signaling from the epidermal growth factor receptor. J. Biol. Chem. 277, 36962-36969.
5. Braga, V.M., Machesky, L.M., Hall, A. & Hotchin, N.A. (1997) The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137, 1421-1431.
6. Clerk, A., Pham, F.H., Fuller, S.J., et al. (2001) Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1. Mol. Cell. Biol. 21, 1173-1184.
7. Coso, O.A., Chiariello, M., Yu, J.C., et al. (1995) The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81, 1137-1146.
8. Eblen, S.T., Slack, J.K., Weber, M.J. & Catling, A.D. (2002) Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol. Cell. Biol. 22, 6023-6033.
9. Ehrlich, J.S., Hansen, M.D.H. & Nelson, W.J. (2002) Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev. Cell 3, 259-270.
10. Gumbiner, B.M. (1996) Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84, 345-357.
11. Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science 279, 509-514.
12. Holland, P.M., Suzanne, M., Campbell, J.S., Noselli, S. & Cooper, J.A. (1997) MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous. J. Biol. Chem. 272, 24994-24998.
13. Honda, T., Shimizu, K., Kawakatsu, T., et al. (2003) Antagonistic and agonistic effects of an extracellular fragment of nectin on formation of E-cadherin-based cell-cell adhesion. Genes Cells 8, 51-63.
14. Ikeda, W., Nakanishi, H., Miyoshi, J., et al. (1999) Afadin: a key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis. J. Cell Biol. 146,1117-1132.
15. Itoh, R.E., Kurokawa, K., Ohba, Y, Yoshizaki, H., Mochizuki, N. & Matsuda, M. (2002) Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells. Mol. Cell. Biol, 22, 6582-6591.
16. Jamora, C. & Fuchs, E. (2002) Intercellular adhesion, signalling and the cytoskeleton. Nature Cell Biol. 4,101-108.
17. Jou, TS. & Nelson, W.J. (1998) Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J. Cell Biol. 142,85-100.
18. Katata, T., Irie, K., Fukuhara, A., et al. (2003) Involvement of nectin in the localization of IQGAP1 at the cell-cell adhesion sites through the actin cytoskeleton in Madin-Darby canine kidney cells. Oncogene 22, 2097-2109.
19. Kawakatsu, T, Shimizu, K., Honda, T, Fukuhara, T., Hoshino, T & Takai, Y (2002) trans-Interactions of nectins induce formation of filopodia and lamellipodia through the respective activation of Cdc42 and Rac small G proteins.J. Biol. Chem. 277, 50749-50755.
20. Kim, S.H., Li, Z. & Sacks, D.B. (2000) E-cadherin-mediated cell-cell attachment activates Cdc42. J Biol. Chem. 275, 36999-37005.
21. Kodama, A., Takaishi, K., Nakano, K., Nishioka, H. & Takai Y. (1999) Involvement of Cdc:42 small G protein in cell-cell adhesion, migration and morphology of MDCK cells. Oncogene 18, 3996-4006.
22. Kovacs, E.M., Ali, R.G., McCormack, AJ. & Yap, A.S. (2002) E-cadherin homophilic ligation directly signals through rac and phosphatidylionsitol 3-kinase to regulate adhesive contacts. J. Biol. Chem. 277, 6708-6718.
23. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
24. Lee, S.H., Eom, M., Lee, S.J., Kim, S., Park, HJ. & Park, D. (2001) BetaPix-enhanced p38 activation by Cdc42/Pac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling. J. Biol. Chem. 276, 25066-25072.
25. Mandai, K., Nakanishi, H., Satoh, A., et al. (1997) Afadin: a novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J. Cell Biol. 139, 517-528.
26. Mandai, K., Nakanishi, H., Satoh, A., et al. (1999) Ponsin/SH3P12: an I-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. J. Cell Biol. 144, 1001-1017.
27. Minden, A., Lin, A., Claret, F.X., Abo, A. & Karin, M. (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81, 1147-1157.
28. Mizoguchi, A., Nakanishi, H., Kimura, K., et al. (2002) Nectin: an adhesion molecule involved in formation of synapses. J. Cell Biol. 156, 555-565.
29. Mosser, D.D., Caron, A.W, Bourget, L., et al. (2000) The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol. Cell. Biol. 20,7146-7159.
30. Nagafuchi, A. (2001) Molecular architecture of adherens junctions. Curr. Opin. Cell Biol. 13, 600-603.
31. Nagafuchi, A., Shirayoshi, Y., Okazaki, K., Yasuda, K. & Takeichi, M. (1987) Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature 329, 341-343.
32. Nakagawa, M., Fukata, M., Yamaga, M., Itoh, N. & Kaibuchi, K. (2001) Recruitment and activation of Racl by the formation of E-cadherin-mediated cell-cell adhesion sites. J. Cell Sci. 114, 1829-1838.
33. Nishioka, H., Mizoguchi, A., Nakanishi, H., et al. (2000) Localization of I-afadin at puncta adhaerentia-likejunctions between the mossy fiber terminals and the dendritic trunks of pyramidal cells in the adult mouse hippocampus. J. Comp. Neurol. 424, 297-306.
34. Noren, N.K., Niessen, C.M., Gumbiner, B.M. & Burridge, K. (2001) Cadherin engagement regulates Rho family GTPases. J. Biol. Chem. 276, 33305-33308.
35. Obaishi, H., Nakanishi, H., Mandai, K., et al. (1998) Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-tertninal kinase. J. Biol. Chem. 273, 18697-18700.
36. Olson, M.F, Ashworth, A. & Hall, A. (1995) An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through Gl. Science 269, 1270-1272.
37. Ozaki-Kuroda, K., Nakanishi, H., Ohta, H., et al. (2002) Nectin couples cell-cell adhesion and actin scaffold at heterotypic testicular junctions. Curr. Biol. 12, 1145-1150.
38. Satoh-Horikawa, K., Nakanishi, H., Takahashi, K., et al. (2000) Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities.J. Biol. Chem. 275, 10291-10299.
39. Tachibana, K., Nakanishi, H., Mandai, K., et al. (2000) Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J. Cell Biol. 150, 1161-1175.
40. Takahashi, K., Nakanishi, H., Miyahara, M., et al. (1999) Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with afadin, a PDZ domain-containing protein. J. Cell Biol. 145, 539-549.
41. Takai, Y & Nakanishi, H. (2003) Nectin and afadin: novel organizers of intercellular junctions. J. Cell Sci. 116, 17-27.
42. Takaishi, K., Sasaki, T., Kotani, H., Nishioka, H. & Takai, Y. (1997) Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J. Cell Biol. 139,1047-1059.
43. Takeichi, M. (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251, 1451-1455.
44. Takenawa, T. & Miki, H. (2001) WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J. Cell Sci. 114, 1801-1809.
45. Villunger, A., O'Reilly, L.A., Holler, N., Adams, J. & Strasser, A. (2000) Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes. J. Exp. Med. 192, 647-658.
46. Weber, K., Prinngle, J.R. & Osborn, M. (1972) Measurement of molecular weights by electrphoresis on SDS-acrylamide gel. Meth. Enzymol. 26, 3-27.
47. Xing, H., Zhang, S., Weinheimer, C., Kovacs, A. & Muslin, A.J. (2000) 14-3-3 proteins block apoptosis and differentially regulate MAPK cascades. EMBO J. 19, 349-358.
48. Yagi, T. & Takeichi, M. (2000) Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. Genes Dev. 14, 1169-1180.
49. Yokoyama, S., Tachibana, K., Nakanishi, H., et al. (2001) α-Catenin-independent recruitment of ZO-1 to nectin-based cell-cell adhesion sites through afadin. Mol. Biol. Cell 12, 1595-1609.
50. Zhang, S., Han, J., Sells, M.A., et al. (1995) Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270, 23934-23936.