Synthesis of 1-Benzyl-4-[(5,[11C] 6-di methoxy-1-oxoindan-2-yl)methyl]piperidine: A promising ligand for visualisation of acetylcholine esterase by PET

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 43, Issue 6, 2000, Pages 595-601

  De Vos, F ^a   Santens, P ^b   Slegers, G ^a   Vermeirsch, H ^a   Dierckx, R A ^b   De Reuck, J ^b  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

11C synthesis; Acetylcholine esterase; Donepezil; PET

Indexed keywords

ALKYLATION; CHELATION; ENZYMES;

11C SYNTHESIS; ACETYLCHOLINE ESTERASE; C-SYNTHESIS; DONEPEZIL; IODOMETHANE; METHOXY; O-METHYLATION; SPECIFIC ACTIVITY;

ESTERS;

ACETYLCHOLINESTERASE; CARBON 11; CHOLINESTERASE INHIBITOR; DONEPEZIL; LIGAND; METHYL IODIDE;

ARTICLE; DRUG FORMULATION; METHYLATION; POSITRON EMISSION TOMOGRAPHY; PURIFICATION; RADIOACTIVITY; SYNTHESIS;

EID: 0034021865     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(200005)43:6<595::AID-JLCR344>3.0.CO;2-B     Document Type: Article

References (21)

1. Travis J. Science News, 148: 118 (1995).
2. Nichols M. Macclean's, 108: 37 (1995).
3. Rossor M.N., Rehfeld J.F., Emson P.C., Mountjoy C.Q., Roth M., Iversen L.L. Life Sci. 29: 405 (1981).
4. Vogels O.J.M., Broere C.A.J., Ter Laak H.J., Ten Donkelaar H.J., Nieuwenhuys R., Schulte B.P.M. Neurobiol. Aging 11: 3 (1990).
5. Richter J.A., Perry E.K., Tomlinson B.E. Life Sci. 26: 1683 (1980).
6. Davies P., Malony A.J.F. Lancet 2: 1403 (1976).
7. Davis K.L., Mohs R.C., Timklenberg J.R. N. Engl. J. Med. 301: 946 (1978).
8. Knapp M.J., Knopman D.S., Solomon P.R., Pendlebury W.W., Davis C.S., Gracon .I. J. Am. Med. Assoc. 271: 985 (1994).
9. Summers W.K, Koehler A.L., Marsh G.M., Tachiki K., Kling A. Lancet 1: 729 (1989).
10. Giacobini E., Somani S., McIlhany M., Downen M., Hallak M. Neuropharmacology 26: 831 (1987).
11. Sugimoto H., Tsuchiya Y., Sugumi H., Higurashi K., Karibe N., Iimura Y., Sasaki A., Kawakami Y., Nakamura T., Araki S., Yamanishi Y., Yamatsu K. J. Med. Chem. 33: 1880 (1990).
12. Becker R.E., Giacobini E. Cholinergic basis for Alzheimer therapy vol.3, Birkhaüser, Boston, 1991, pp 314.
13. Sugimoto H., Iimura Y., Yamanishi Y., Yamatsu K. J. Med. Chem. 38: 4821 (1995).
14. Kryger G., Silman I., Sussman J. J. Physiol. Paris. 92: 191 (1998).
15. Irie T., Fukushi K., Namba H., Iyo M., Tamagami H., Nagatsuka S. Ikota N. J. Nucl. Med. 37: 649 (1996).
16. Kilbourn M.R., Snyder S.E., Sherman P.S., Kuhl D.E. Synapse 22: 123 (1996)
17. Iyo M., Namba H., Fukushi K., Shinotoh H., Nagatsuka S., Suhara T., Sudo Y., Suzuki K., Irie T. Lancet 349: 1805 (1997).
18. Tavitian B., Pappata S., Plannas A.M., Jobert A., Bonnot-Lours S., Crouzel C., Di-Giamberardino L. Neuroreport 4: 535 (1993).
19. Tavitian B., Pappata S., Bonnot-Lours S., Prenant C., Jobert A., Crouzel C., Di-Giamberardino L. Eur. J. Pharmacol. 236: 229 (1993).
20. European Pharmacopoeia Commission. - A proposal for a guideline for residual solvent levels in drug substances and excipients used for the preparation of medicinal products form the working party "Residual solvents (toxicology)" (1994).
21. Crouzel C., L̊Angström B., Pike V., Coenen H. Appl. Radiat. Isot. 38: 601 (1987).