Synergistic action of quercetin and genistein in human ovarian carcinoma cells

Oncology Research

Volumn 9, Issue 11-12, 1997, Pages 597-602

  Shen, Fei ^a   Weber, George ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Genistein; Ovarian carcinoma; Quercetin; Signal transduction

Indexed keywords

ANTINEOPLASTIC AGENT; GENISTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; QUERCETIN;

ARTICLE; CELL CULTURE; CELL DIVISION; CELL SURVIVAL; DRUG COMBINATION; DRUG EFFECT; DRUG POTENTIATION; FEMALE; HUMAN; METABOLISM; OVARY TUMOR; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL SURVIVAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; GENISTEIN; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; OVARIAN NEOPLASMS; QUERCETIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0031324596     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Parker, S. L.; Tong, T.; Bolden, S.; Wingo, P. A. Cancer statistics. Cancer 46:5-29; 1996.
2. Look, K. Y.; Moore, D. H.; Sutton, G. P.; Prajda, N.; Abonyi, M.; Weber, G. Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma. Anticancer Res. 17:2353-2356; 1997.
3. Singhal, R. L.; Yeh, Y. A.; Look, K.; Sledge, G. W., Jr.; Weber, G. Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells. Life Sci. 55:1487-1492; 1994.
4. Weber, G. Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture. Cancer Res. 43:3466-3492; 1983.
5. Liu, B.; Anderson, D.; Ferry, D. R.; Seymour, L. W.; de Takats, P. G.; Kerr, D. J. Determination of quercetin in human plasma using reversed-phase high-performance liquid hromatography. J. Chromatogr. B Biomed. Appl. 666:149-155; 1995.
6. Weber, G.; Shen, F.; Prajda, N.; Yeh, Y. A.; Yang, H.; Herenyiova, M.; Look, K. Y. Increased signal transduction activity and down-regulation in human cancer cells. Anticancer Res. 16:3271-3282; 1996.
7. Peterson, G. Evaluation of the biochemical targets of genistein in tumor cells. J. Nutr. 125:784s-789s; 1995.
8. Yoshida, M.; Sakai, T.; Hosokawa, N.; Marui, N.; Natusmoto, K.; Kujioka, A.; Nishino, H.; Aoike, A. The effect of quercetin on cell cycle progression and growth of human gastric cancer cells. FEBS Lett. 260:10-13; 1990.
9. Hosokawa, N.; Hosokawa, Y.; Sakai, T.; Yoshida, M.; Marui, N.; Nishino, H.; Kawai, K.; Aoika, A. Inhibitory effect of quercetin on the synthesis of a possibly cell-cycle-related 17-KDA protein, in human colon cancer cells. Int. J. Cancer 45:1119-1124; 1990.
10. 2-M. Cancer Res. 53:1328-1331; 1993.
11. Pagliacci, M. C.; Spinozzi, F.; Migliorati, G.; Fumi, G.; Smacchia, M.; Grignani, F.; Riccardi, C.; Nicoletti, I. Genistein inhibits tumor cell growth in vitro but enhances mitochondrial reduction of tetrazolium salts: A future pitfall in the use of the MTT assay for evaluating cell growth and survival. Eur. J. Cancer 29A:1573-1577; 1993.
12. Hunakova, L.; Sedlak, J.; Klobusicka, M.; Duraj, J.; Chorvath, B. Tyrosine kinase inhibitor-induced differentiation of K-562 cells: Alterations of cell cycle and cell surface phenotype. Cancer Lett. 81:81-87; 1994.
13. Rauth, S.; Kichina, J.; Green, A. Inhibition of growth and induction of differentiation of metastatic melanoma cells in vitro by genistein: Chemosensitivity is regulated by cellular p53. Br. J. Cancer 75:1559-1566; 1997.
14. Nishioka, N.; Imoto, M.; Sawa, T.; Hamada, M.; Naganawa, H.; Takeuchi, T.; Umezawa, K. Screening of phosphatidylinositol kinase inhibitors from streptomyces. J. Antibiot. 42: 823-825; 1989.
15. Prajda, N.; Singhal, R. L.; Yeh, Y. A.; Olah, E.; Look, K. Y.; Weber, G. Linkage of reduction in 1-phosphatidylinositol 4-kinase activity and inositol 1,4,5-trisphosphate concentration in human ovarian carcinoma cells treated with quercetin. Life Sci. 56:1587-1593; 1995.
16. 2+ mobilization in human platelets by affecting polyphosphoinositide turnover. Biochem. Pharmacol. 46:395-403; 1993.
17. Weber, G.; Shen, F.; Prajda, N.; Yang, H.; Li, W.; Yeh, A.; Csokay, B.; Olah, E.; Look, K. Y. Regulation of the signal transduction program by drugs. Adv. Enzyme Regul. 37:35-55; 1997.
18. Weber, G.; Nagai, M.; Prajda, N.; Nakamura, H.; Szekeres, T.; Olah, E. AZT: A biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells. Cancer Commun. 3:127-132; 1991.
19. Olah, E.; Lui, M. S.; Tzeng, D. Y.; Weber, G. Phase and cell cycle specificity of pyrazofurin action. Cancer Res. 40:2869-2875; 1980.
20. Singhal R. L.; Prajda, N.; Yeh, Y. A.; Weber, G. 1-Phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68): A proliferation- and malignancy-linked signal transduction enzyme. Cancer Res. 54:5574-5578; 1994.
21. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurement with the Polin phenol reagent. J. Biol. Chem. 193:265-275; 1951.
22. Webb, J. L. Enzyme and metabolic inhibitors, vol. 1. New York: Academic Press; 1963:507-510.
23. Berenbaum, M. C. Criteria for analyzing interactions between biologically active agents. Adv. Cancer Res. 35:269-335; 1981.
24. Rana, R. S.; Hokin, L. E. Role of phosphoinositides in transmembrane signaling. Physiol. Rev. 70:115-164; 1990.
25. Berridge, M. J. Inositol trisphosphate and calcium signalling. Nature 361:315-325; 1993.
26. Kuno, M.; Gardner, P. Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes. Nature 326:301-304; 1987.
27. Kohn, E. C.; Jacobs, W.; Kim, Y. S.; Alessandro, R.; Stetier-Stevenson, W. G.; Liotta, L. A. Calcium influx modulated expression of matrix metalloproteinase-2 (72kDa type IV colIagenase, gelatinase A). J. Biol. Chem. 269:21505-21511; 1994.
28. Wei, Y. Q.; Zhao, X.; Kariya, Y.; Fukata, H.; Teshigawara, K.; Uchida, A. Induction of apoptosis by quercetin: Involvement of heat shock protein. Cancer Res. 54:4952-4957; 1994.
29. Csokay, B.; Prajda, N.; Weber, G.; Olah, E. Molecular mechanisms in the antiproliferative action of quercetin. Life Sci. 60:2157-2163; 1997.
30. Kyle, E.; Neckers, L.; Takimoto, C.; Curt, G.; Bergan, R. Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol. Pharmacol. 51:193-200; 1997.