The synthetic phytoestrogen, ipriflavone, and estrogen prevent bone loss by different mechanisms

Calcified Tissue International

Volumn 66, Issue 1, 2000, Pages 61-65

  Arjmandi, B H ^a   Birnbaum, R S ^b,c   Juma, S ^a   Barengolts, E ^d   Kukreja, S C ^d  

^a OKLAHOMA STATE UNIVERSITY   (United States)

^b Puget Sound Health Care System   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

Estrogens; Isoflavones; Osteoporosis ovariectomy; Rats

Indexed keywords

EID: 0033407481     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002230050012     Document Type: Article

References (32)

1. Havsteen B (1983) Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol 32:11411148
2. Yamazaki I, Shino A, Shimizu Y, Tskuda R, Shirakawa Y, Kinoshita M (1986) Effect of ipriflavone on glucocorticoidinduced osteoporosis in rats. Life Sci 38:951-958
3. Agnusdei D, Zacchei F, Bigazzi S, Cepollaro C, Nardi P, Montagnani M, Gennari C (1989) Metabolic and clinical effects of ipriflavone in established post-menopausal osteoporosis. Drugs Exp Clin Res 15:97-104
4. Shino A, Matsuo T, Tsuda M, Yamazaki I, Tsukuda R, Kitazaki T, Shiota K, Okada H, Yoshida K (1986) Effect of ipriflavone on bone and mineral metabolism in the streptozotocin diabetic rats. J Bone Miner Metab 3:177-187
5. Yamazaki I, Shino A, Tsukuda R (1986) Effect of ipriflavone on osteoporosis induced by ovariectomy in rats. J Bone Miner Metab 3:205-210
6. Melis GB, Paoletti AM, Cagnacci A, Bufalino L, Spinetti A, Gambacciani M, Fioretti P (1992) Lack of any estrogenic effect of ipriflavone in postmenopausal women. J Endocrinol Invest 15:755-761
7. Nakamura S, Morimoto S, Takamoto S, Onishi T, Fukuo K, Koh E, Kitano S, Miyashita Y, Yasuda O, Tamatani M, Nakahashi T, Ogihara T (1992) Effect of ipriflavone on bone mineral density and calcium-related factors in elderly females. Calcif Tissue Int 51(suppl 1):S30-S34
8. Albanese CV, Cudd A, Argentine L, Zambonin-Zallone A, Maclntyre I (1994) Ipriflavone directly inhibits osteoclastic activity. Biochem Biophys Res Comm 199:930-936
9. Notoya K, Yoshida K, Taketomi S, Yamazaki I, Kumegawa M (1993) Inhibitory effect of ipriflavone on osteoclast-mediated bone résorption and new osteoclast formation in long-term cultures of mouse unfractionated bone cells. Calcif Tissue Int 53:206-209
10. Bonucci E, Ballanti P, Martelli A, Mereto E, Brambilla G, Bianco P, Bufalino L (1992) Ipriflavone inhibits osteoclast differentiation in parathyroid transplanted parietal bone of rats. Calcif Tissue Int 50:314-319
11. Benvenuti S, Tanini A, Frediani U, Bianchi S, Masi L, Casano R, Bufalino L, Serio M, Brandi ML (1991) Effect of ipriflavone and its metabolites on a clonal osteoblastic cell line. J Bone Miner Res 6:987-996
12. Notoya K, Tsukuda R, Yoshida K, Taketomi S (1992) Stimulatory effect of ipriflavone on formation of bone-like tissue in rat bone marrow stromal cell culture. Calcif Tissue Int 51(suppl 1):S16-S20
13. Storm T, Thamsborg G, Steiniche T, Genaut HK, Sorenen OH (1990) Effect of intermittent cyclic etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. N Engl J Med 322:1265-1271
14. Mosekilde L, Sogaard CH, McOsker JE, Wronski TJ (1994) PTH has a more pronounced effect on vertebral bone mass and biomechanical competence than antiresorptive agents (estrogen and bisphosphonate)-assessed in sexually mature, ovariectomized rats. Bone 15:401-08
15. Rogers MJ, Chilton KM, Coxon FP, Lawry J, Smith MO, Suri S, Russell RG (1996) Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism. J Bone Miner Res 11:1482-1491
16. Van der Pluijm G, Vloedgraven H, van Beek E, Van der Wee-Pals L, Lowik C, Papapoulos S (1996) Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro. J Clin Invest 98:698-705
17. Kalu DN, Arjmandi BH, Liu CC, Salih MA, Birnbaum RS (1993) Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3. Bone Miner 25:135-148
18. Arjmandi BH, Alekel L, Hollis BW, Amin D, StacewiczSapuntzakis M, Gou P, Kukreja SC (1996) Dietary soy protein prevents bone loss in an ovariectomized rat model of osteoporosis. J Nutr 126:161-167
19. Barengolts El, Lathon PV, Lindh FG (1995) Progesterone antagonist RU 486 has bone-sparing effects in ovariectomized rats. Bone 17:21-25
20. Snedecor GW, Cochran WG (1967) Statistical methods. Iowa State University Press, Ames, Iowa
21. Chew V (1977) Comparisons among treatment means in an analysis of variance. US Department of Agriculture, Hyattsville, MD
22. Kalu DN (1991) The ovariectomized rat model of postmenopausal bone loss (review). Bone Miner 15:175-192
23. Kalu DN, Salerno E, Liu CC, Echon R, Ray M, Garza-Zapata M, Hollis B W (1991) A comparative study of the actions of tamoxifen, estrogen and progesterone in the ovariectomized rat. Bone Miner 15:109-123
24. Cecchini MG, Fleisch H, Muhibauer RC (1997) Ipriflavone inhibits bone résorption in intact and ovariectomized rats. Calcif Tissue Int 61(suppl 1):S9-S11
25. Martin PM, Horwitz KB, Ryan DS, McGuire WL (1978) Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Endocrinology 103:1860-1867
26. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci 93:5925-5930
27. Onoe Y, Miyaura C, Ohta H, Nozawa S, Suda T (1997) Expression of estrogen receptor beta in rat bone. Endocrinology 138:4509-4512
28. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138:863-870
29. Suda A (1987) Effect of parathyroid hormone on parietal bones of rats, and effect of ipriflavone. J Bone Miner Metab 5:51-56
30. Civitelli R, Abbasi-Jarhomi SH, Halstead LR, Dimarogonas A (1995) Ipriflavone improves bone density and biomechanical properties of adult male rat bones. Calcif Tissue Int 56:215219
31. de Aloysio D, Gambacciani M, Altieri P, Ciaponi M, Ventura V, Mura M, Genazzani AR, Bottiglionni F (1997) Bone density changes in postmenopausal women with the administration of ipriflavone alone or in association with low-dose ERT. Gynecol Endocrinol 11:289-293
32. Sugimoto T, Nishiyama K, Kuribayashi F, Chihara K (1997) Serum levels of insulin-like growth factor (IGF) 1, IGFbinding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures. J Bone Miner Res 12:1272-1279