Expression of estrogen receptor-alpha in cells of the osteoclastic lineage

Histochemistry and Cell Biology

Volumn 111, Issue 2, 1999, Pages 125-133

  Oreffo, R O C ^a   Kusec, V ^a   Virdi, A S ^a   Flanagan, A M ^b   Grano, M ^c   Zambonin Zallone, A ^c   Triffitt, J T ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR;

ARTICLE; CELL LINEAGE; CELL PROLIFERATION; FETUS; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; OSTEOCLAST; OSTEOLYSIS; PATHOPHYSIOLOGY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DENSITY;

BONE DISEASES; BONE MARROW CELLS; BONE NEOPLASMS; BREAST NEOPLASMS; CELL LINEAGE; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION; GIANT CELL TUMORS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MUSCLE, SKELETAL; OSTEOCLASTS; RECEPTORS, ESTROGEN; RNA, MESSENGER; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 0033054576     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180050342     Document Type: Article

References (52)

1. Arnett TR, Lindsay R, Kilb JM, Moonga BS, Spowage M, Dempster DW (1996) Selective toxic effects of tamoxifen on osteoclasts: comparison with the effects of oestrogen. J Endocrinol 149:503-508
2. Arts J, Kuiper GGJM, Janssen JMMF, Gustafson J-A, Löwik CWGM, Pols HAP, Van Leeuwen JPTM (1997) Differential expression of estrogen receptors α and β mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138:5067-5070
3. Bodine PVN, Henderson RA, Green J, Aronow M, Owen T, Stein GS, Lian JB, Komm BS (1998) Estrogen receptor-α is developmentally regulated during osteoblast differentiation and contributes to selective responsiveness of gene expression. Endocrinology 139:2048-2057
4. Brubaker KD, Gay CV (1994) Specific binding of estrogen to osteoclast surfaces. Biochem Biophys Res Commun 200:899-907
5. Collier FM, Huang WH, Holloway WR, Hodge JM, Gillespie MT, Daniels LL, Zheng MH, Nicholson GC (1998) Osteoclasts from human giant cell tumors of bone lack estrogen receptors. Endocrinology 139:1258-1267
6. Colston KW, King RJB, Hayward J, Fraser DI, Horton MA, Stevenson JC, Arnett TR (1989) Estrogen receptors and human bone cells. Immunocytochemical studies. J Bone Miner Res 4:625-632
7. Couse JF, Lindzey J, Grandien K, Gustafsson J-Å, Korach KS (1997) Tissue distribution and quantitative analysis of estrogen receptor-α (ERα) and estrogen receptor-β (Erβ) messenger ribonucleic acid in the wild-type and Era-knockout mouse. Endocrinology 138:4613-4621
8. Davies J, Warwick J, Tutty N, Philip R, Helfrich M, Horton MA (1989) The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol 109:1817-1826
9. Davis VL, Couse JF, Gray TK, Korach KS (1994) Correlation between low levels of estrogen receptors and estrogen responsiveness in two rat osteoblast-like cell lines. J Bone Miner Res 9:983-991
10. Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL (1988) Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241:84-86
11. Ernst M, Parker MG, Rodan GA (1991) Functional estrogen receptors in osteoblastic cells demonstrated by transfection with a reporter gene containing an estrogen response element. Mol Endocrinol 5:1597-1606
12. Ettinger B, Genant HK, Cann CE (1985) Long-term estrogen replacement therapy prevents bone loss and fractures. Annals of Internal Medicine 102:319-324
13. Fiorelli G, Gori F, Petilli M, Tanini A, Benvenuti A, Serio M, Bernabei P, Brandi ML (1995) Functional estrogen receptors in a human preosteoclastic cell line. Proc Natl Acad Sci USA 92:2672-2676
14. Girasole G, Jilka JR, Passeri G, Boswell S, Boder G, Williams DC, Manolagus SC (1992) 17β estrogen inhibits IL-6 production by bone marrow-derived stromal cells and osteoblasts in vitro. A potential mechanism for the antiosteoporotic effects of oestrogens. J Clin Invest 89:883-891
15. Grano M, Colucci S, De Bellis M, Zigrino P, Argentino L, Zambonin G, Serra M, Scotlandi K, Teti A, Zambonin Zallone A (1994) New model for bone resorption study in vitro: human osteoclast-like cells from giant cell tumors of bone. J Bone Min Res 7:1013-1020
16. Hoyland JA, Mee AP, Baird P, Braidman IP, Mawer EB, Freemont AJ (1997) Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction. Bone 20:87-92
17. Hughes DE, Dai A, Tiffee JC, Li HH, Mundy GR, Boyce BF (1996) Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-β. Nature Med 2:1132-1136
18. Huo B, Dossing DA, Dimuzio MT (1995) Generation and characterization of a human osteosarcoma cell line stably transfected with the human estrogen receptor gene. J Bone Miner Res 10: 769-781
19. Jemtland R, Lee K, Segre GV (1998) Heterogeneity among cells that express osteoclast-associated genes in developing bone. Endocrinology 139:340-349
20. Jilka RC, Hangoc G, Girasone G, Passeri P, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC 1992 Increased osteoclast development after estrogen loss. Mediation by IL-6. Science 257:88-91
21. Kameda T, Mano H, Yuasa T, Mori Y, Miyazawa K, Shiokawa M, Nakamaru Y, Hiroi E, Hiura K, Kameda A, Yang Na N, Hakeda Y, Kumegawa M 1997 Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med 186:489-495
22. Kassem M, Harris SA, Spelsberg TC, Riggs BL (1996) Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors. J Bone Min Res 11:193-199
23. Komm BS, Terpening CM, Benz DJ, Graeme KA, Gallegas A, Kore M, Greene GL, O'Mally BW Haussler MR (1988) Estrogen binding receptor mRNA and biologic response in osteoblast-like osteosarcoma cells. Science 241:81-84
24. Korach KS (1994) Insights from the study of animals lacking functional estrogen receptor. Science 266:1524-1527
25. Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafson J-Å (1996) Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930
26. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson J-Å (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138:863-870
27. Kusec V, Virdi AS, Prince R, Kenwright J, Triffitt JT (1996) Localisation of estrogen receptor mRNA in skeletal cells by in situ hybridisation. In: Papapoulos SE et al. (eds) Osteoporosis. Elsevier Science, Amsterdam, pp 29-35
28. Kusec V, Virdi AS, Prince R, Triffitt JT (1998) Localisation of estrogen receptor a in human and rabbit skeletal tissues. J Clin Endocrinol Metab 83:2421-2428
29. 2, interleukin 1α, and tumour necrosis factor-α increase human osteoclast formation and bone resorption in vitro. Endocrinology 139: 3157-3164
30. Lajeunesse D (1994) Effect of 17 beta-estradiol on human osteosarcoma cell line MG-63. Bone Mineral 24:1-16
31. Lindsay R, Cosman F (1992) Primary osteoporosis. In: Coe FL, Favus MJ (eds) Disorders of bone and mineral metabolism. Raven Press, New York, pp 841
32. Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson JB, Clarke AC (1976) Long-term prevention of postmenopausal osteoporosis by estrogen. Lancet I:1038-1041
33. Mano H, Yuasa T, Kameda T, Miyazawa K, Nakamura Y, Shiokawa M, Mori Y, Yamada T, Miyata K, Shindo H, Azuma H, Hakeda Y, Kumegawa M (1996) Mammalian osteoclasts as estrogen target cells. Biochem. Biophysics Res Commun 223: 637-642
34. Mosselman S, Polman J, Dijkema R (1996) ERβ: identification and characterization of a novel human estrogen receptor. FEBS Lett 392:49-53
35. Ohashi T, Kusuhara S, Ishida K (1991) Estrogen target cells during the early stage of medullary bone osteogenesis: immuno-histochemical detection of estrogen receptors in osteogenic cells of estrogen-treated male Japanese quail. Calcif Tissue Int 49:124-127
36. Onoe Y, Miyaura C, Ohta H, Nozawa S, Suda T (1997) Expression of estrogen receptor β in rat bone. Endocrinology 138: 4509-4512
37. Oreffo ROC, Virdi AS, Triffitt JT (1997) Modulation of osteogenesis and adipogenesis by human serum in human bone marrow cultures. Eur J Cell Biol 74:251-261
38. Oursler MJ, Osdoby P, Pyfferon J, Riggs BL, Spelsberg TC (1991) Avian osteoclasts as estrogen target cells. Proc Natl Acad Sci USA 88:6613-6617
39. Oursler MJ, Pederson L, Fitzpatrick L, Riggs BL, Spelsberg T (1994) Human giant cell tumours of the bone (osteoclastomas) are estrogen target cells. Proc Natl Acad Sci USA 91: 5227-5231.
40. Parfitt AM (1979) Quantum concept of bone remodeling and turnover: Implications for the pathogenesis of osteoporosis. Calcif Tissue Int 28:1-5
41. Prince RL (1994) Counterpoint: estrogen effects on calcitropic hormones and calcium homeostasis. Endocr Rev 15:301-309
42. Richelson LS, Wahner HW, Melton LT III, Riggs BL (1984) Relative contributions of aging and estrogen deficiency to postmenopausal bone loss. V Eng T Med 311:1273
43. Robinson JA, Harris SA, Riggs BL, Spelsberg TC (1997) Estrogen regulation of human osteoblastic cell proliferation and differentiation. Endocrinology 138:2919-2927
44. Sarma U, Flanagan AM (1996) Macrophage colony-stimulating factor induces substantial osteoclast generation and bone resorption in human bone marrow cultures. Blood 88:2531-2540
45. Sarma U, Edwards M, Motoyoshi K, Flanagan M (1998) Inhibition of bone resorption by 17β estradiol in human bone-marrow cultures. J Cell Physiol 175:99-108
46. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS (1994) Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Eng J Med 331:1056-1061
47. Suda T, Nakamura I, Jimi E, Takahashi N (1997) Regulation of osteoclast function. J Bone Miner Res 12:869-879
48. Tamura T, Takahashi N, Akatsu T, Sasaki T, Udagawa N, Tanaka S, Suda T (1993) New resorption assay with mouse osteoclast-like multinucleated cells formed in vitro. J Bone Miner Res 8:953-960
49. Tremblay GB, Tremblay A, Copeland NG, Gilbert DJ, Jenkins NA, Labrie F, Giguere V (1997) Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor β. Mol Endocrinol 11:353-365
50. Turner RT, Backup P, Sherman PJ, Hill E, Evans GL, Spelsberg TC (1992) Mechanism of action of estrogen on intramembranous bone formation: regulation of osteoblast differentiation and activity. Endocrinology 131:883-889
51. Vedi S, Compston JE (1996) The effects of long-term hormone replacement therapy on bone remodeling in postmenopausal women. Bone 19:535-539
52. Zheng MH, Holloway W, Fan Y, Collier F, Criddle A, Prince R, Wood DJ, Nicholson GC (1995) Evidence that human osteoclast-like cells are not the major estrogen target cells. Bone 16:[Suppl 1]93 S, abstract 50