A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: The HERITAGE Family Study

Diabetes

Volumn 52, Issue 6, 2003, Pages 1583-1587

  Lakka, Timo A ^a,b   Rankinen, Tuomo ^a   Weisnagel, S John ^c   Chagnon, Yvon C ^c   Rice, Treva ^d   Leon, Arthur S ^e   Skinner, James S ^f   Wilmore, Jack H ^g   Rao, D C ^d   Bouchard, Claude ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITÉ LAVAL   (Canada)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f INDIANA UNIVERSITY   (United States)

^g TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; LEPTIN;

ADOLESCENT; ADULT; ARTICLE; CHROMOSOME 7Q; DIABETOGENESIS; EXERCISE; FEMALE; GENOME; HUMAN; INSULIN BLOOD LEVEL; LINKAGE ANALYSIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RACE DIFFERENCE; RISK ASSESSMENT;

AFRICAN CONTINENTAL ANCESTRY GROUP; CANADA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 7; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXERCISE; FAMILY; FEMALE; GENETIC MARKERS; GENOME, HUMAN; HUMANS; INSULIN; LINKAGE (GENETICS); MALE; PHYSICAL ENDURANCE; QUANTITATIVE TRAIT LOCI; UNITED STATES;

EID: 0037644895     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.6.1583     Document Type: Article

References (34)

1. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 23 (Suppl. 1):S4-S19, 2000
2. American Diabetes Association, National Institute of Diabetes, Digestive and Kidney Diseases: The prevention or delay of type 2 diabetes. Diabetes Care 25:742-749, 2002
3. Sakul H, Pratley R, Cardon L, Ravussin E, Mott D, Bogardus C: Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians. Am J Hum Genet 60:651-656, 1997
4. Hong Y, Weisnagel SJ, Rice T, Sun G, Mandel SA, Gu C, Rankinen T, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Bergman RN, Bouchard C, Rao DC: Familial resemblance for glucose and insulin metabolism indices derived from an intravenous glucose tolerance test in Blacks and Whites of the HERITAGE Family Study. Clin Genet 60:22-30, 2001
5. Ross R, Dagnone D, Jones PJ, Smith H, Paddags A, Hudson R, Janssen I: Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men: a randomized, controlled trial. Ann Intern Med 133:92-103, 2000.
6. Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, Hennekens CH: A prospective study of exercise and incidence of diabetes among U.S. male physicians. JAMA 268:63-67, 1992
7. Lynch J, Helmrich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R, Salonen JT: Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in nuddle-aged men. Arch Intern Med 156:1307-1314, 1996
8. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M, Finnish Diabetes Prevention Study Group: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343-1350, 2001
9. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Diabetes Prevention Program Research Group; Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403, 2002
10. Bouchard C, Rankinen T: Individual differences in response to regular physical activity. Med Sci Sports Exerc 33 (Suppl. 6):S446-S451, 2001 (discussion S452-S453)
11. Pratley RE, Thompson DB, Prochazka M, Baier L, Mott D, Ravussin E, Sakul H, Ehm MG, Burns DK, Foroud T, Garvey WT, Hanson RL, Knowler WC, Bennett PH, Bogardus C: An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J Clin Invest 101:1757-1764, 1998
12. Watanabe RM, Ghosh S, Langefeld CD, Valle TT, Hauser ER, Magnuson VL, Mohlke KL, Silander K, Ally DS, Chines P, Blaschak-Harvan J, Douglas JA, Duren WL, Epstein MP, Fingerlin TE, Kaleta HS, Lange EM, Li C, McEachin RC, Stringham HM, Trager E, White PP, Balow Jr J, Birznieks G, Chang J, Eldridge W: The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci. Am J Hum Genet 67:1186-1200, 2000
13. Cheng LS, Davis RC, Raffel LJ, Xiang AH, Wang N, Quinones M, Wen PZ, Toscano E, Diaz J, Pressman S, Henderson PC, Azen SP, Hsueh WA, Buchanan TA, Rotter JI: Coincident linkage of fasting plasma insulin and blood pressure to chromosome 7q in hypertensive Hispanic families. Circulation 104:1255-1260, 2001
14. Duggirala R, Stern MP, Mitchell BD, Reinhart LJ, Shipman PA, Uresandi OC, Chung WK, Leibel RL, Hales CN, O'Connell P, Blangero J: Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. Am J Hum Gerber 59:694-703, 1996
15. Ehm MG, Karnoub MC, Sakul H, Gottschalk K, Holt DC, Weber JL, Vaske D, Briley D, Briley L, Kopf J, McMillen P, Nguyen Q, Reisman M, Lai EH, Joslyn G, Shepherd NS, Bell C, Wagner MJ, Burns DK, the American Diabetes Association GENNID Study Group: Genomewide search for type 2 diabetes susceptibility genes in four American populations. Am J Hum Genet 66:1871-1881, 2000
16. Hanson RL, Ehm MG, Pettitt DJ, Prochazka M, Thompson DB, Timberlake D, Foroud T, Kobes S, Baler L, Burns DK, Almasy L, Blangero J, Garvey WT, Bennett PH, Knowler WC: An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. Am J Hum Genet 63:1130-1138, 1998
17. Hsueh WC, Mitchell BD, Schneider JL, St Jean PL, Pollin TI, Ehm MG, Wagner MJ, Burns DK, Sakul H, Bell CJ, Shuldiner AR: Genome-wide scan of obesity in the Old Order Amish. J Clin Endocrinol Metab 86:1199-1205, 2001
18. Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH, Gagnon J: The HERITAGE family study: aims, design, and measurement protocol. Med Sci Sports Exerc 27:721-729, 1995
19. Chagnon YC, Borecki IB, Perusse L, Roy S, Lacaille M, Chagnon M, Ho-Kim MA, Rice T, Province MA, Rao DC, Bouchard C: Genome-wide search for genes related to the fat-free body mass in the Quebec Family Study. Metabolism 49:203-207, 2000
20. Rice T, Borecki IB, Bouchard C, Rao DC: Commingling analysis of regional fat distribution measures: the Quebec Family Study. Int J Obes Relat Metab Disord 16:831-844, 1992
21. Elston RC, Buxbaum S, Jacobs KB, Olson JM: Haseman and Elston revisited. Genet Epidemiol 19:1-17, 2000
22. Statistical Analysis for Genetic Epidemiology. Cork, Ireland, Statistical Solutions, 2002
23. Rao DC, Province MA: The future of path analysis, segregation analysis, and combined models for genetic dissection of complex traits. Hum Hered 50:34-42, 2000
24. Feitosa MF, Borecki IB, Rich SS, Arnett DK, Sholinsky P, Myers RH, Leppert M, Province MA: Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet 70:72-82, 2002
25. Perusse L, Rice T, Chagnon YC, Despres JP, Lemieux S, Roy S, Lacaille M, Ho-Kim MA, Chagnon M, Province MA, Rao DC, Bouchard C: A genome-wide scan for abdominal fat assessed by computed tomography in the Quebec Family Study. Diabetes 50:614-621, 2001
26. Arya R, Blangero J, Williams K, Almasy L, Dyer TD, Leach RJ, O'Connell P, Stern MP, Duggirala R: Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans. Diabetes 51:841-847, 2002
27. Newgard CB, Brady MJ, O'Doherty RM, Saltiel, AR: Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. Diabetes 49:1967-1977, 2000
28. Xia J, Scherer SW, Cohen PT, Majer M, Xi T, Norman RA, Knowler WC, Bogardus C, Prochazka M: A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. Diabetes 47:1519-1524, 1998
29. Hansen L, Hansen T, Vestergaard H, Bjorbaek C, Echwald SM, Clausen JO, Chen YH, Chen MX, Cohen PT, Pedersen O: A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. Hum Mol Genet 4:1313-1320, 1995
30. Wauters M, Considine RV, Van Gaal LF: Human leptin: from an adipocyte hormone to an endocrine mediator. Eur J Endocrinol 143:293-311, 2000
31. Leviev I, Kalix B, Brulhart Meynet MC, James RW: The paraoxonase PON1 promoter polymorphism C(-107)T is associated with increased serum glucose concentrations in non-diabetic patients. Diabetologia, 44:1177-1183, 2001
32. Bektas A, Hughes JN, Warram JH, Krolewski AS, Doria A: Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes. Diabetes 50:204-208, 2001
33. Ristow M, Vorgerd M, Mohlig M, Schatz H, Pfeiffer A: Deficiency of phosphofructo-1-kinase/muscle subtype in humans impairs insulin secretion and causes insulin resistance. J Clin Invest 100:2833-2841, 1997
34. Hanson RL, Pratley RE, Bogardus C, Narayan KM, Roumain JM, Imperatore G, Fagot-Campagna A, Pettitt DJ; Bennett PH, Knowler WC: Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol 151:190-198, 2000