-
1
-
-
0029166667
-
A synthetic inhibitor of the mitogen-activated protein kinase cascade
-
Dudley, D.T., Pang, L., Decker, S.J., Bridges, A.J., and Saltiel, A.R. (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl Acad. Sci. USA 92, 7686-7689
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7686-7689
-
-
Dudley, D.T.1
Pang, L.2
Decker, S.J.3
Bridges, A.J.4
Saltiel, A.R.5
-
2
-
-
0032552994
-
MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products
-
Duncia, J.V., Santella, J.B., 3rd, Higley, C.A., Pitts, W.J., Wityak, J., Frietze, W.E., Rankin, F.W., Sun, J.H., Earl, R.A., Tabaka, A.C., Teleha, C.A., Blom, K.F., Favata, M.F., Manos, E.J., Daulerio, A.J., Stradley, D.A., Horiuchi, K., Copeland, R.A., Scherle, P.A., Trzaskos, J.M., Magolda, R.L., Trainor, G.L., Wexler, R.R., Hobbs, F.W., and Olson, R.E. (1998) MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg. Med. Chem. Lett. 8, 2839-2844
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 2839-2844
-
-
Duncia, J.V.1
Santella J.B. III2
Higley, C.A.3
Pitts, W.J.4
Wityak, J.5
Frietze, W.E.6
Rankin, F.W.7
Sun, J.H.8
Earl, R.A.9
Tabaka, A.C.10
Teleha, C.A.11
Blom, K.F.12
Favata, M.F.13
Manos, E.J.14
Daulerio, A.J.15
Stradley, D.A.16
Horiuchi, K.17
Copeland, R.A.18
Scherle, P.A.19
Trzaskos, J.M.20
Magolda, R.L.21
Trainor, G.L.22
Wexler, R.R.23
Hobbs, F.W.24
Olson, R.E.25
more..
-
3
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee, J.C., Laydon, J.T., McDonnell, P.C., Gallagher, T.F., Kumar, S., Green, D., McNulty, D., Blumenthal, M.J., Heys, J.R., Landvatter, S.W., Strickler, J.E., McLaughlin, M.M., Siemens, I.R., Fisher, S.M., Livi, G.P., White, J.R., Adams, J.L., and Young, P.R. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739-746
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heys, J.R.9
Landvatter, S.W.10
Strickler, J.E.11
McLaughlin, M.M.12
Siemens, I.R.13
Fisher, S.M.14
Livi, G.P.15
White, J.R.16
Adams, J.L.17
Young, P.R.18
-
4
-
-
0028988138
-
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
-
Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., Young, P.R., and Lee, J.C. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364, 229-233
-
(1995)
FEBS Lett.
, vol.364
, pp. 229-233
-
-
Cuenda, A.1
Rouse, J.2
Doza, Y.N.3
Meier, R.4
Cohen, P.5
Gallagher, T.F.6
Young, P.R.7
Lee, J.C.8
-
5
-
-
0030426902
-
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
-
Badger, A.M., Bradbeer, J.N., Votta, B., Lee, J.C., Adams, J.L., and Griswold, D.E. (1996) Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 279, 1453-1461
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.279
, pp. 1453-1461
-
-
Badger, A.M.1
Bradbeer, J.N.2
Votta, B.3
Lee, J.C.4
Adams, J.L.5
Griswold, D.E.6
-
6
-
-
0034931503
-
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
-
Han, Z., Boyle, D.L., Chang, L., Bennett, B., Karin, M., Yang, L., Manning, A.M., Firestein, G.S., Aupperle, K.R., Shi, Y., Green, D.R., Rutter, J.L., and Brinckerhoff, C.E. (2001) c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J. Clin. Invest. 108, 73-81
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 73-81
-
-
Han, Z.1
Boyle, D.L.2
Chang, L.3
Bennett, B.4
Karin, M.5
Yang, L.6
Manning, A.M.7
Firestein, G.S.8
Aupperle, K.R.9
Shi, Y.10
Green, D.R.11
Rutter, J.L.12
Brinckerhoff, C.E.13
-
7
-
-
0034097998
-
ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells
-
Kurosawa, M., Numazawa, S., Tani, Y., and Yoshida, T. (2000) ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells. Amer. J. Physiol. Cell Physiol. 278, C500-508
-
(2000)
Amer. J. Physiol. Cell Physiol.
, vol.278
-
-
Kurosawa, M.1
Numazawa, S.2
Tani, Y.3
Yoshida, T.4
-
9
-
-
15844376168
-
The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells
-
Watabe, M., Masuda, Y., Nakajo, S., Yoshida, T., Kuroiwa, Y., and Nakaya, K. (1996) The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells. J. Biol. Chem. 271, 14067-14072
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 14067-14072
-
-
Watabe, M.1
Masuda, Y.2
Nakajo, S.3
Yoshida, T.4
Kuroiwa, Y.5
Nakaya, K.6
-
10
-
-
0005318501
-
Effect of SB 203580 on the activity of c-Raf in vitro and in vivo
-
Hall-Jackson, C.A., Goedert, M., Hedge, P., and Cohen, P. (1999) Effect of SB 203580 on the activity of c-Raf in vitro and in vivo. Oncogene 18, 2047-2054
-
(1999)
Oncogene
, vol.18
, pp. 2047-2054
-
-
Hall-Jackson, C.A.1
Goedert, M.2
Hedge, P.3
Cohen, P.4
-
11
-
-
0033179479
-
Paradoxical activation of Raf by a novel Raf inhibitor
-
Hall-Jackson, C.A., Eyers, P.A., Cohen, P., Goedert, M., Boyle, F.T., Hewitt, N., Plant, H., and Hedge, P. (1999) Paradoxical activation of Raf by a novel Raf inhibitor. Chem. Biol. 6, 559-568
-
(1999)
Chem. Biol.
, vol.6
, pp. 559-568
-
-
Hall-Jackson, C.A.1
Eyers, P.A.2
Cohen, P.3
Goedert, M.4
Boyle, F.T.5
Hewitt, N.6
Plant, H.7
Hedge, P.8
-
12
-
-
0022364132
-
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
-
March, C.J., Mosley, B., Larsen, A., Cerretti, D.P., Braedt, G., Price, V., Gillis, S., Henney, C.S., Kronheim, S.R., Grabstein, K., Conlon, P.J., Hopp, T.P., and Cosman, D. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 315, 641-647
-
(1985)
Nature
, vol.315
, pp. 641-647
-
-
March, C.J.1
Mosley, B.2
Larsen, A.3
Cerretti, D.P.4
Braedt, G.5
Price, V.6
Gillis, S.7
Henney, C.S.8
Kronheim, S.R.9
Grabstein, K.10
Conlon, P.J.11
Hopp, T.P.12
Cosman, D.13
-
13
-
-
0022401902
-
1.5 kb mRNA abundantly expressed in rat tumors encodes a 37 kilodalton protein in vitro
-
Maehara, Y., Fujiyoshi, T., Takahashi, K., Yamamoto, M., and Endo, H. (1985) 1.5 kb mRNA abundantly expressed in rat tumors encodes a 37 kilodalton protein in vitro. Biochem. Biophys. Res. Commun. 131, 800-805
-
(1985)
Biochem. Biophys. Res. Commun.
, vol.131
, pp. 800-805
-
-
Maehara, Y.1
Fujiyoshi, T.2
Takahashi, K.3
Yamamoto, M.4
Endo, H.5
-
14
-
-
0028935270
-
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
-
Raingeaud, J., Gupta, S., Rogers, J.S., Dickens, M., Han, J., Ulevitch, R.J., and Davis, R.J. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270, 7420-7426
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7420-7426
-
-
Raingeaud, J.1
Gupta, S.2
Rogers, J.S.3
Dickens, M.4
Han, J.5
Ulevitch, R.J.6
Davis, R.J.7
-
15
-
-
0032712288
-
Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells
-
Cambien, B., Millet, M.A., Schmid-Antomarchi, H., Brossette, N., Rossi, B., and Schmid-Alliana, A. (1999) Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells. J. Immunol. 163, 5079-5085
-
(1999)
J. Immunol.
, vol.163
, pp. 5079-5085
-
-
Cambien, B.1
Millet, M.A.2
Schmid-Antomarchi, H.3
Brossette, N.4
Rossi, B.5
Schmid-Alliana, A.6
-
16
-
-
0027379044
-
A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines
-
Gray, J.G., Chandra, G., Clay, W.C., Stinnett, S.W., Haneline, S.A., Lorenz, J.J., Patel, I.R., Wisely, G.B., Furdon, P.J., Taylor, J.D., and Kost, T.A. (1993) A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines. Mol. Cell. Biol. 13, 6678-6689
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 6678-6689
-
-
Gray, J.G.1
Chandra, G.2
Clay, W.C.3
Stinnett, S.W.4
Haneline, S.A.5
Lorenz, J.J.6
Patel, I.R.7
Wisely, G.B.8
Furdon, P.J.9
Taylor, J.D.10
Kost, T.A.11
-
17
-
-
0034667593
-
Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
-
Kolch, W. (2000) Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J. 351, 289-305
-
(2000)
Biochem. J.
, vol.351
, pp. 289-305
-
-
Kolch, W.1
-
18
-
-
18544406054
-
SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence
-
Underwood, D.C., Osborn, R.R., Kotzer, C.J., Adams, J.L., Lee, J.C., Webb, E.F., Carpenter, D.C., Bochnowicz, S., Thomas, H.C., Hay, D.W., and Griswold, D.E. (2000) SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. J. Pharmacol. Exp. Ther. 293, 281-288
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.293
, pp. 281-288
-
-
Underwood, D.C.1
Osborn, R.R.2
Kotzer, C.J.3
Adams, J.L.4
Lee, J.C.5
Webb, E.F.6
Carpenter, D.C.7
Bochnowicz, S.8
Thomas, H.C.9
Hay, D.W.10
Griswold, D.E.11
-
19
-
-
0026556859
-
Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element
-
Dalton, S. and Treisman, R. (1992) Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell 68, 597-612
-
(1992)
Cell
, vol.68
, pp. 597-612
-
-
Dalton, S.1
Treisman, R.2
-
20
-
-
0026695645
-
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter
-
Gille, H., Sharrocks, A.D., and Shaw, P.E. (1992) Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358, 414-417
-
(1992)
Nature
, vol.358
, pp. 414-417
-
-
Gille, H.1
Sharrocks, A.D.2
Shaw, P.E.3
-
21
-
-
0034905018
-
Pyridinyl imidazole inhibitor SB203580 activates p44/42 mitogen-activated protein kinase and induces the differentiation of human myeloid leukemia cells
-
Ishii, Y., Sakai, S., and Honma, Y. (2001) Pyridinyl imidazole inhibitor SB203580 activates p44/42 mitogen-activated protein kinase and induces the differentiation of human myeloid leukemia cells. Leuk. Res. 25, 813-820
-
(2001)
Leuk. Res.
, vol.25
, pp. 813-820
-
-
Ishii, Y.1
Sakai, S.2
Honma, Y.3
-
22
-
-
0033812246
-
The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway
-
Birkenkamp, K.U., Tuyt, L.M., Lummen, C., Wierenga, A.T., Kruijer, W., and Vellenga, E. (2000) The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway. Br. J. Pharmacol. 131, 99-107
-
(2000)
Br. J. Pharmacol.
, vol.131
, pp. 99-107
-
-
Birkenkamp, K.U.1
Tuyt, L.M.2
Lummen, C.3
Wierenga, A.T.4
Kruijer, W.5
Vellenga, E.6
-
23
-
-
0033215340
-
Two co-existing mechanisms for nuclear import of MAP kinase: Passive diffusion of a monomer and active transport of a dimer
-
Adachi, M., Fukuda, M., and Nishida, E. (1999) Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBO J. 18, 5347-5358
-
(1999)
EMBO J.
, vol.18
, pp. 5347-5358
-
-
Adachi, M.1
Fukuda, M.2
Nishida, E.3
-
24
-
-
0035831516
-
Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase
-
Zhang, H., Shi, X., Hampong, M., Blanis, L., and Pelech, S. (2001) Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase. J. Biol. Chem. 276, 6905-6908
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 6905-6908
-
-
Zhang, H.1
Shi, X.2
Hampong, M.3
Blanis, L.4
Pelech, S.5
-
25
-
-
0028022750
-
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
-
Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T., and Nebreda, A.R. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78, 1027-1037
-
(1994)
Cell
, vol.78
, pp. 1027-1037
-
-
Rouse, J.1
Cohen, P.2
Trigon, S.3
Morange, M.4
Alonso-Llamazares, A.5
Zamanillo, D.6
Hunt, T.7
Nebreda, A.R.8
-
26
-
-
0030977270
-
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
-
Fukunaga, R. and Hunter, T. (1997) MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16, 1921-1933
-
(1997)
EMBO J.
, vol.16
, pp. 1921-1933
-
-
Fukunaga, R.1
Hunter, T.2
-
27
-
-
0032479983
-
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
-
Deak, M., Clifton, A.D., Lucocq, L.M., and Alessi, D.R. (1998) Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17, 4426-4441
-
(1998)
EMBO J.
, vol.17
, pp. 4426-4441
-
-
Deak, M.1
Clifton, A.D.2
Lucocq, L.M.3
Alessi, D.R.4
-
28
-
-
0032526694
-
PRAK, a novel protein kinase regulated by the p38 MAP kinase
-
New, L., Jiang, Y., Zhao, M., Liu, K., Zhu, W., Flood, L.J., Kato, Y., Parry, G.C., and Han, J. (1998) PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 17, 3372-3384
-
(1998)
EMBO J.
, vol.17
, pp. 3372-3384
-
-
New, L.1
Jiang, Y.2
Zhao, M.3
Liu, K.4
Zhu, W.5
Flood, L.J.6
Kato, Y.7
Parry, G.C.8
Han, J.9
-
29
-
-
0035823588
-
The absence of AP-1-dependent gene expression in THP-1 macrophages stimulated with phorbol esters is due to lack of p38 MAP kinase activation
-
Carter, A.B., Tephly, L.A., and Hunninghake, G.W. (2001) The absence of AP-1-dependent gene expression in THP-1 macrophages stimulated with phorbol esters is due to lack of p38 MAP kinase activation. J. Biol. Chem. 276, 33826-33832
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33826-33832
-
-
Carter, A.B.1
Tephly, L.A.2
Hunninghake, G.W.3
|