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Volumn 33, Issue 8, 2003, Pages 821-831

Identification and characterisation of high affinity nucleoside and nucleobase transporters in Toxoplasma gondii

Author keywords

Apicomplexan; Nucleobase transporter; Nucleoside transporter; Purine salvage; Pyrimidine uptake; Toxoplasma gondii

Indexed keywords

ADENOSINE; GUANINE; HYPOXANTHINE; INOSINE; NUCLEIC ACID BASE; NUCLEOSIDE; THYMIDINE; URIDINE; XANTHINE;

EID: 0037629329     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(03)00091-2     Document Type: Article
Times cited : (65)

References (49)
  • 1
    • 0037379670 scopus 로고    scopus 로고
    • A Leishmania major nucleobase transporter responsible for allopurinol uptake is a functional homologue of the Trypanosoma brucei H2 transporter
    • Al-Salabi M.I., Wallace L.J.M., De Koning H.P. A Leishmania major nucleobase transporter responsible for allopurinol uptake is a functional homologue of the Trypanosoma brucei H2 transporter. Mol. Pharmacol. 63:2003;814-820.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 814-820
    • Al-Salabi, M.I.1    Wallace, L.J.M.2    De Koning, H.P.3
  • 2
    • 0029051349 scopus 로고
    • Biochemical and molecular characterization of nucleoside triphosphate hydrolase isozymes from the parasitic protozoan Toxoplasma gondii
    • Asai T., Miura S., Sibley L.D., Okabayashi H., Takeuchi T. Biochemical and molecular characterization of nucleoside triphosphate hydrolase isozymes from the parasitic protozoan Toxoplasma gondii. J. Biol. Chem. 270:1995;11391-11397.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11391-11397
    • Asai, T.1    Miura, S.2    Sibley, L.D.3    Okabayashi, H.4    Takeuchi, T.5
  • 4
    • 0033136943 scopus 로고    scopus 로고
    • Nucleoside transporters: Molecular biology and implications for therapeutic development
    • Baldwin S.A., Mackey J.R., Cass C.E., Young J.D. Nucleoside transporters: molecular biology and implications for therapeutic development. Mol. Med. Today. 5:1999;216-224.
    • (1999) Mol. Med. Today , vol.5 , pp. 216-224
    • Baldwin, S.A.1    Mackey, J.R.2    Cass, C.E.3    Young, J.D.4
  • 6
    • 0027500261 scopus 로고
    • Arsenical-resistant trypanosomes lack an unusual adenosine transporter
    • Carter N.S., Fairlamb A.H. Arsenical-resistant trypanosomes lack an unusual adenosine transporter. Nature. 361:1993;173-175.
    • (1993) Nature , vol.361 , pp. 173-175
    • Carter, N.S.1    Fairlamb, A.H.2
  • 7
    • 0034615934 scopus 로고    scopus 로고
    • Isolation and functional characterization of the PfNT1 nucleoside transporter gene from Plasmodium falciparum
    • Carter N.S., Ben Mamoun C., Liu W., Silva E.O., Landfear S.M., Goldberg D.E., Ullmann B. Isolation and functional characterization of the PfNT1 nucleoside transporter gene from Plasmodium falciparum. J. Biol. Chem. 275:2000;10683-10691.
    • (2000) J. Biol. Chem. , vol.275 , pp. 10683-10691
    • Carter, N.S.1    Ben Mamoun, C.2    Liu, W.3    Silva, E.O.4    Landfear, S.M.5    Goldberg, D.E.6    Ullmann, B.7
  • 8
    • 0034617220 scopus 로고    scopus 로고
    • Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant
    • Carter N.S., Drew M.E., Sanchez M., Vasudevan G., Landfear S.M., Ullman B. Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant. J. Biol. Chem. 275:2000;20935-20941.
    • (2000) J. Biol. Chem. , vol.275 , pp. 20935-20941
    • Carter, N.S.1    Drew, M.E.2    Sanchez, M.3    Vasudevan, G.4    Landfear, S.M.5    Ullman, B.6
  • 11
    • 0032868347 scopus 로고    scopus 로고
    • Recombinant expression, purification and characterization of Toxoplasma gondii adenosine kinase
    • Darling J.A., Sullivan W.J., Carter D., Ullman B., Roos D.S. Recombinant expression, purification and characterization of Toxoplasma gondii adenosine kinase. Mol. Biochem. Parasitol. 103:1999;15-23.
    • (1999) Mol. Biochem. Parasitol. , vol.103 , pp. 15-23
    • Darling, J.A.1    Sullivan, W.J.2    Carter, D.3    Ullman, B.4    Roos, D.S.5
  • 12
    • 0031018089 scopus 로고    scopus 로고
    • Stimulated transport of hypoxanthine in Crithidia luciliae: Relationship to purine stress
    • Day R.E., Gero A.M. Stimulated transport of hypoxanthine in Crithidia luciliae: relationship to purine stress. Parasitology. 114:1997;19-27.
    • (1997) Parasitology , vol.114 , pp. 19-27
    • Day, R.E.1    Gero, A.M.2
  • 13
    • 0035119571 scopus 로고    scopus 로고
    • Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: Implications for cross-resistance with arsenicals
    • De Koning H.P. Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. Mol. Pharmacol. 59:2001;586-592.
    • (2001) Mol. Pharmacol. , vol.59 , pp. 586-592
    • De Koning, H.P.1
  • 15
    • 0030849192 scopus 로고    scopus 로고
    • Hypoxanthine uptake through a purine-selective nucleobase transporter in Trypanosoma brucei brucei procyclics is driven by protonmotive force
    • De Koning H.P., Jarvis S.M. Hypoxanthine uptake through a purine-selective nucleobase transporter in Trypanosoma brucei brucei procyclics is driven by protonmotive force. Eur. J. Biochem. 247:1997;1102-1110.
    • (1997) Eur. J. Biochem. , vol.247 , pp. 1102-1110
    • De Koning, H.P.1    Jarvis, S.M.2
  • 16
    • 0030767791 scopus 로고    scopus 로고
    • Purine nucleobase transport in bloodstream forms of Trypanosoma brucei brucei is mediated by two novel transporters
    • De Koning H.P., Jarvis S.M. Purine nucleobase transport in bloodstream forms of Trypanosoma brucei brucei is mediated by two novel transporters. Mol. Biochem. Parasitol. 89:1997;245-258.
    • (1997) Mol. Biochem. Parasitol. , vol.89 , pp. 245-258
    • De Koning, H.P.1    Jarvis, S.M.2
  • 17
    • 0032540245 scopus 로고    scopus 로고
    • Characterisation of a nucleoside/proton symporter in procyclic Trypanosoma brucei brucei
    • De Koning H.P., Watson C.J., Jarvis S.M. Characterisation of a nucleoside/proton symporter in procyclic Trypanosoma brucei brucei. J. Biol. Chem. 273:1998;9486-9494.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9486-9494
    • De Koning, H.P.1    Watson, C.J.2    Jarvis, S.M.3
  • 18
    • 0032732283 scopus 로고    scopus 로고
    • Purine transporters in bloodstream forms of Trypanosoma brucei brucei: Substrate recognition motifs and affinity for trypanocidal drugs
    • De Koning H.P., Jarvis S.M. Purine transporters in bloodstream forms of Trypanosoma brucei brucei: substrate recognition motifs and affinity for trypanocidal drugs. Mol. Pharmacol. 56:1999;1162-1170.
    • (1999) Mol. Pharmacol. , vol.56 , pp. 1162-1170
    • De Koning, H.P.1    Jarvis, S.M.2
  • 19
    • 0029895115 scopus 로고    scopus 로고
    • Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene. Use as a selectable marker for stable transformation
    • Donald R.G.K., Carter D., Ullman B., Roos D.S. Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene. Use as a selectable marker for stable transformation. J. Biol. Chem. 271:1996;14010-14019.
    • (1996) J. Biol. Chem. , vol.271 , pp. 14010-14019
    • Donald, R.G.K.1    Carter, D.2    Ullman, B.3    Roos, D.S.4
  • 20
    • 0020454434 scopus 로고
    • The specificity of purine base and nucleoside uptake in promastigotes of Leishmania braziliensis panamensis
    • Hansen B.D., Perez-Arbelo J., Walkony J.F., Hendricks L.D. The specificity of purine base and nucleoside uptake in promastigotes of Leishmania braziliensis panamensis. Parasitology. 85:1982;271-282.
    • (1982) Parasitology , vol.85 , pp. 271-282
    • Hansen, B.D.1    Perez-Arbelo, J.2    Walkony, J.F.3    Hendricks, L.D.4
  • 21
    • 0022515641 scopus 로고
    • De novo synthesis of purines by Acanthamoeba castellanii and A. astronyxis
    • Hassan H.F., Coombs G.H. De novo synthesis of purines by Acanthamoeba castellanii and A. astronyxis. IRCS Med. Sci. 14:1986;559-560.
    • (1986) IRCS Med. Sci. , vol.14 , pp. 559-560
    • Hassan, H.F.1    Coombs, G.H.2
  • 22
    • 0034483903 scopus 로고    scopus 로고
    • Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: The structural basis for catalysis
    • Héroux A., White E.L., Ross L.J., Kuzin A.P., Borhani D.W. Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis. Structure. 8:2000;1309-1318.
    • (2000) Structure , vol.8 , pp. 1309-1318
    • Héroux, A.1    White, E.L.2    Ross, L.J.3    Kuzin, A.P.4    Borhani, D.W.5
  • 23
    • 0034995844 scopus 로고    scopus 로고
    • The ENT family of eukaryote nucleoside and nucleobase transporters: Recent advances in the investigation of structure/function relationships and the identification of novel isoforms
    • Hyde R.J., Cass C.E., Young J.D., Baldwin S.A. The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms. Mol. Membr. Biol. 18:2001;53-63.
    • (2001) Mol. Membr. Biol. , vol.18 , pp. 53-63
    • Hyde, R.J.1    Cass, C.E.2    Young, J.D.3    Baldwin, S.A.4
  • 24
    • 0027418029 scopus 로고
    • Toxoplasma gondii: A protozoan for the nineties
    • Joiner K.A., Dubremetz J.F. Toxoplasma gondii: a protozoan for the nineties. Infect. Immun. 61:1993;1169-1172.
    • (1993) Infect. Immun. , vol.61 , pp. 1169-1172
    • Joiner, K.A.1    Dubremetz, J.F.2
  • 25
    • 0035069258 scopus 로고    scopus 로고
    • Membrane transport in the malaria-infected erythrocyte
    • Kirk K. Membrane transport in the malaria-infected erythrocyte. Physiol. Rev. 81:2001;495-537.
    • (2001) Physiol. Rev. , vol.81 , pp. 495-537
    • Kirk, K.1
  • 26
    • 0031929681 scopus 로고    scopus 로고
    • Isolation of developmentally regulated genes from Toxoplasma gondii by a gene trap with the positive and negative selectable marker hypoxanthine-xanthine-guanine phosphoribosyltransferase
    • Knoll L.J., Boothroyd J.C. Isolation of developmentally regulated genes from Toxoplasma gondii by a gene trap with the positive and negative selectable marker hypoxanthine-xanthine-guanine phosphoribosyltransferase. Mol. Cell. Biol. 18:1998;807-814.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 807-814
    • Knoll, L.J.1    Boothroyd, J.C.2
  • 27
    • 0024340636 scopus 로고
    • Purine metabolism in Toxoplasma gondii
    • Krug E.C., Marr J.J., Berens R.L. Purine metabolism in Toxoplasma gondii. J. Biol. Chem. 264:1989;10601-10607.
    • (1989) J. Biol. Chem. , vol.264 , pp. 10601-10607
    • Krug, E.C.1    Marr, J.J.2    Berens, R.L.3
  • 29
    • 0036096540 scopus 로고    scopus 로고
    • Identification and characterization of differentiation mutants in the protozoan parasite Toxoplasma gondii
    • Matrajt M., Donald R.G.K., Singh U., Roos D.S. Identification and characterization of differentiation mutants in the protozoan parasite Toxoplasma gondii. Mol. Microbiol. 44:2002;735-747.
    • (2002) Mol. Microbiol. , vol.44 , pp. 735-747
    • Matrajt, M.1    Donald, R.G.K.2    Singh, U.3    Roos, D.S.4
  • 30
    • 0028826429 scopus 로고
    • Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii
    • Naguib F.N.M., Iltzsch M.H., El Kouni M.M., Panzica R.P., El Kouni M.H. Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. Biochem. Pharmacol. 50:1995;1685-1693.
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 1685-1693
    • Naguib, F.N.M.1    Iltzsch, M.H.2    El Kouni, M.M.3    Panzica, R.P.4    El Kouni, M.H.5
  • 31
    • 0033861577 scopus 로고    scopus 로고
    • Are host cell adenosine nucleotides a direct source for purine salvage?
    • Ngo H.M., Ngo E.O., Bzik D.J., Joiner K.A. Are host cell adenosine nucleotides a direct source for purine salvage? Exp. Parasitol. 95:2000;148-153.
    • (2000) Exp. Parasitol. , vol.95 , pp. 148-153
    • Ngo, H.M.1    Ngo, E.O.2    Bzik, D.J.3    Joiner, K.A.4
  • 32
    • 0034235518 scopus 로고    scopus 로고
    • Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy
    • Parker M.D., Hyde R.J., Yao S.Y.M., McRobert L., Cass C.E., Young J.D., McConkey G.A., Baldwin S.A. Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy. Biochem. J. 349:2000;67-75.
    • (2000) Biochem. J. , vol.349 , pp. 67-75
    • Parker, M.D.1    Hyde, R.J.2    Yao, S.Y.M.3    McRobert, L.4    Cass, C.E.5    Young, J.D.6    McConkey, G.A.7    Baldwin, S.A.8
  • 33
  • 34
    • 0023914919 scopus 로고
    • Toxoplasma gondii: In vivo and in vitro studies of a mutant resistant to arprinocid-N-oxide
    • Pfefferkorn E.R., Eckel M.E., McAdams E. Toxoplasma gondii: in vivo and in vitro studies of a mutant resistant to arprinocid-N-oxide. Exp. Parasitol. 65:1988;282-289.
    • (1988) Exp. Parasitol. , vol.65 , pp. 282-289
    • Pfefferkorn, E.R.1    Eckel, M.E.2    McAdams, E.3
  • 39
    • 0028115808 scopus 로고
    • The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve
    • Schwab J.C., Beckers C.J., Joiner K.A. The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve. Proc. Natl Acad. Sci. USA. 91:1994;509-513.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 509-513
    • Schwab, J.C.1    Beckers, C.J.2    Joiner, K.A.3
  • 40
    • 0020026153 scopus 로고
    • Toxoplasma gondii: Purine synthesis and salvage in mutant host cells and parasites
    • Schwartzman J.D., Pfefferkorn E.R. Toxoplasma gondii: purine synthesis and salvage in mutant host cells and parasites. Exp. Parasitol. 53:1982;77-86.
    • (1982) Exp. Parasitol. , vol.53 , pp. 77-86
    • Schwartzman, J.D.1    Pfefferkorn, E.R.2
  • 41
    • 0027973621 scopus 로고
    • Toxoplasma gondii: Secretion of a potent nucleoside triphosphate hydrolase into the parasitophorous vacuole
    • Sibley L.D., Niesman I.R., Asai T., Takeuchi T. Toxoplasma gondii: secretion of a potent nucleoside triphosphate hydrolase into the parasitophorous vacuole. Exp. Parasitol. 79:1994;301-311.
    • (1994) Exp. Parasitol. , vol.79 , pp. 301-311
    • Sibley, L.D.1    Niesman, I.R.2    Asai, T.3    Takeuchi, T.4
  • 42
    • 0032524883 scopus 로고    scopus 로고
    • Induced activation of the Toxoplasma gondii nucleoside triphosphate hydrolase leads to depletion of host cell ATP levels and rapid exit of intracellular parasites from infected cells
    • Silverman J.A., Qi H., Riehl A., Beckers C., Nakaar V., Joiner K.A. Induced activation of the Toxoplasma gondii nucleoside triphosphate hydrolase leads to depletion of host cell ATP levels and rapid exit of intracellular parasites from infected cells. J. Biol. Chem. 273:1998;12352-12359.
    • (1998) J. Biol. Chem. , vol.273 , pp. 12352-12359
    • Silverman, J.A.1    Qi, H.2    Riehl, A.3    Beckers, C.4    Nakaar, V.5    Joiner, K.A.6
  • 44
    • 0028836011 scopus 로고
    • Hypoxanthine-guanine phosphoribosyltransferase as a therapeutic target in protozoal infections
    • Ullman B., Carter D. Hypoxanthine-guanine phosphoribosyltransferase as a therapeutic target in protozoal infections. Infect. Agents Dis. 4:1995;29-40.
    • (1995) Infect. Agents Dis. , vol.4 , pp. 29-40
    • Ullman, B.1    Carter, D.2
  • 46
    • 0037135609 scopus 로고    scopus 로고
    • Different substrate recognition motifs of human and trypanosome nucleobase transporters: Selective uptake of purine antimetabolites
    • Wallace L.J.M., Candlish D., De Koning H.P. Different substrate recognition motifs of human and trypanosome nucleobase transporters: selective uptake of purine antimetabolites. J. Biol. Chem. 277:2002;29149-29156.
    • (2002) J. Biol. Chem. , vol.277 , pp. 29149-29156
    • Wallace, L.J.M.1    Candlish, D.2    De Koning, H.P.3
  • 47
    • 0021332120 scopus 로고
    • Parasite enzymes as potential targets for antiparasitic chemotherapy
    • Wang C.C. Parasite enzymes as potential targets for antiparasitic chemotherapy. J. Med. Chem. 27:1984;1-9.
    • (1984) J. Med. Chem. , vol.27 , pp. 1-9
    • Wang, C.C.1
  • 48
    • 0030883947 scopus 로고    scopus 로고
    • Validating targets for antiparasite chemotherapy
    • Wang C.C. Validating targets for antiparasite chemotherapy. Parasitology. 114:1997;S31-S44.
    • (1997) Parasitology , vol.114
    • Wang, C.C.1
  • 49


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