Gonadal and adrenal effects on the glucocorticoid receptor in the rat hippocampus, with special reference to regulation by estrogen from an immunohistochemical view-point

Neuroscience Research

Volumn 46, Issue 2, 2003, Pages 205-218

  Sheng, Zijing ^a   Yanai, Akie ^a   Fujinaga, Ryutaro ^a   Kawano, June ^a   Tanaka, Mayumi ^a   Watanabe, Yoshifumi ^a   Shinoda, Koh ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adrenalectomy; Corticosterone; Estradiol; Gonadectomy; Immunohistochemistry; Stress

Indexed keywords

CORTICOSTERONE; ESTRADIOL; ESTROGEN; GLUCOCORTICOID RECEPTOR; SEX HORMONE;

ADRENAL GLAND; ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DISPERSION; ESTROGEN ACTIVITY; FEMALE; GONAD; GONADECTOMY; HIPPOCAMPUS; HORMONAL REGULATION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RAT; REGULATORY MECHANISM; SEX DIFFERENCE;

EID: 0037614903     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(03)00056-7     Document Type: Article

References (68)

1. Ahima R.S., Lawson A.N., Osei S.Y., Harlan R.E. Sexual dimorphism in regulation of type II corticosteroid receptor immunoreactivity in the rat hippocampus. Endocrinology. 3:1992;1409-1416.
2. Bamberger C.M., Bamberger A.M., de Castro M., Chrousos G.P. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J. Clin. Invest. 95:1995;2435-2441.
3. Bamberger C.M., Schulte H.M., Chrousos G.P. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr. Rev. 17:1996;245-261.
4. Barden N. Modulation of glucocorticoid receptor gene expression by antidepressant drugs. Pharmacopsychiatry. 1:1996;12-22.
5. Behi C., Holsboer F. The female sex hormone oestrogen as a neuroprotectant. TIPS. 9:1999;441-444.
6. Biagini G., Pich E.M., Carani C., Marrama P., Gustafsson J.A., Fuxe K., Agnati L.F. Indole-pyruvic acid, a tryptophan ketoanalogue, antagonizes the endocrine but not the behavioral effects of repeated stress in a model of depression. Biol. Psychiatry. 33:1993;712-719.
7. Burgess L.H., Handa R.J. Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion and glucocorticoid receptor-mediated functions in female rats. Endocrinology. 131:1992;1261-1269.
8. Carey M.P., Deterd C.H., de Koning J., Helmerhorst F., de Kloet E.R. The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat. J. Endocrinol. 144:1995;311-321.
9. De Castro M., Elliot S., Kino T., Bamberger C., Karl M., Webster E., Chrousos G.P. The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential physiologic role. Mol. Med. 2:1996;597-607.
10. De Kloet E.R., Burbach P., Mulder G.H. Localization and role of transcortin-like molecules in the anterior pituitary. Mol. Cell Endocrinol. 7:1977;261-273.
11. De Kloet E.R., Vreugdenhil E., Oitzl M.S., Joels M. Brain corticosteroid receptor balance in health and disease. Endocr. Rev. 19:1998;269-301.
12. Dellovade T.L., Blaustein J.D., Rissman E.F. Neural distribution of estrogen receptor immunoreactive cells in the female musk shrew. Brain Res. 595:1992;189-194.
13. Encio I.J., Detera-Wadleigh S.D. The genomic structure of the human glucocorticoid receptor. J. Biol. Chem. 266:1991;7182-7188.
14. Ferrini M., De Nicola A.F. Estrogens up-regulate type 1 and type 2 glucocorticoid receptors in brain regions from ovariectomized rats. Life Sci. 48:1991;2593-2601.
15. Ferrini M., Lima A., De Nicola A.F. Estradiol abolishes autologous down regulation of glucocorticoid receptors in brain. Life Sci. 26:1995;2403-2412.
16. Ferrini M., Piroli G., Frontera M., Falbo A., Lima A., DeNicola A.F. Estrogens normalize the hypothalamic-pituitary-adrenal axis response to stress and increase glucocorticoid receptor immunoreactivity in hippocampus of aging male rats. Neuroendocrinology. 69:1999;129-137.
17. Fink G., Sumner B.E.H., Rosie R., Grace O., Quinn J.P. Estrogen control of central neurotransmission: effect on mood, mental state and memory. Cell Mol. Neurobiol. 16:1996;325-344.
18. Gibbs R.B. Effects of estrogen on basal forebrain cholinergic neurons vary as a function of dose and duration of treatment. Brain Res. 757:1997;10-16.
19. Henderson S.R., Baker C., Fink G. Oestradiol-17beta and pituitary responsiveness to luteinizing hormone releasing factor in the rat: a study using rectangular pulses of oestradiol-17beta monitored by non-chromatographic radioimmunoassay. J. Endocrinol. 73:1977;441-453.
20. Hollenberg S.M., Weinberger C., Ong E.S., Cerelli G., Oro A., Lebo R., Thompson E.B., Rosenfeld M.G., Evans R.M. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature. 318:1985;635-641.
21. Holsboer F. Psychiatric implications of altered limbic-hypothalamic-pituitary-adrenocortical activity. Eur. Arch. Psychiat. Neuro. Sci. 238:1989;302-322.
22. Holsboer F., Barden N. Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr. Rev. 17:1996;187-205.
23. Issa A.M., Rowe W., Gauthier S., Meaney M.J. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats. J. Neurosci. 10:1990;3247-3254.
24. Jacobson L., Sapolsky R. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr. Rev. 12:1991;118-134.
25. Karandrea D., Kittas C., Kitraki E. Forced swimming differentially affects male and female brain corticosteroid receptors. Neuroendocrinology. 75:2002;217-226.
26. Koch M., Ehret G. Immunocytochemical localization and quantification of estrogen-binding cells in the male and female (virgin, pregnant, lactating) mouse brain. Brain Res. 489:1989;101-112.
27. Lauber A.H., Mobbs C.V., Muramatsu M., Pfaff D.W. Estrogen receptor messenger RNA expression in rat hypothalamus as a function of genetic sex and estrogen dose. Endocrinology. 129:1991;3180-3186.
28. Li X., Schwartz P.E., Rissman E.F. Distribution of estrogen receptor-beta-like immunoreactivity in rat forebrain. Neuroendocrinology. 66:1997;63-67.
29. Lignieres B., Vincens M. Differential effects of exogenous and progesterone on mood in post-menopausal women: individual dose/effect relationship. Maturitas. 4:1982;67-72.
30. Lindheim S.R., Legro R.S., Bernstein L., Stanczyk F.Z., Vijod M.A., Presser S.C., Lobo R.A. Behavioral stress responses in premenopausal and postmenopausal women and the effects of estrogen. Am. J. Obstet. Gynecol. 167:1992;1831-1836.
31. McEwen B.S., Alves S.E. Estrogen actions in the central nervous system. Endocr. Rev. 3:1999;279-307.
32. McEwen B.S., de Kloet E.R., Rostene W. Adrenal steroid receptors and actions in the nervous system. Physiol. Rev. 66:1986;1121-1188.
33. McGimsey W.C., Cidlowski J.A., Stumpf W.E., Sar M. Endogenous ovarian steroids maintain immunocytochemical nuclear localization of glucocorticoid receptor in adrenalectomized female rat brain. Soc. Neurosci. Abstr. 17:1991;1362.
34. Mizoguchi K., Luine V., Chui D.H., Tabira T. Stress induces neuronal death in the hippocampus of castrated rated rats. Neurosci. Lett. 138:1992;157-160.
35. Montkowski A., Barden N., Wotjak C., Stec I., Ganster J., Meaney M., Engelmann M., Reul J.M., Landgraf R., Holsboer F. Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function. J. Neuroendocrinol. 11:1995;841-845.
36. Morano M.I., Vazquez D.M., Akil H. The role of the hippocampal mineralocorticoid and glucocorticoid receptors in the hypothalamo-pituitary-adrenal axis of the aged Fisher rat. Mol. Cell Neurosci. 5:1994;400-412.
37. Mufson E.J., Cai W.J., Jaffar S., Chen E., Stebbins G., Sendera T., Kordower J.H. Estrogen receptor immunoreactivity within subregions of the rat forebrain: neuronal distribution and association with perikarya containing choline acetyltransferase. Brain Res. 849:1999;253-274.
38. Oakley R.H., Sar M., Cidlowski J.A. The human glucocorticoid receptor beta isoform. J. Biol. Chem. 16:1996;9550-9559.
39. Orikasa C., McEwen B.S., Hayashi H., Sakuma Y., Hayashi S. Estrogen receptor alpha, but not beta, is expressed in the interneurons of the hippocampus in prepubertal rats: an in-situ hybridization study. Brain Res. Dev. Brain Res. 120:2000;245-254.
40. Osterlund M., Kuiper G.G., Gustafsson J.A., Hurd Y.L. Differential distribution and regulation of estrogen receptor-alpha and -beta mRNA within the female rat brain. Brain Res. Mol. Brain Res. 54:1998;175-180.
41. Packard M.G., Teather L.A. Intra-hippocampal estradiol infusion enhances memory in ovariectomized rats. Neuroreport. 8:1997;3009-3013.
42. Pariante C.M., Pearce B.D., Pisell T.L., Owens M.J., Miller A.H. Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Mol. Pharmacol. 4:1997;571-581.
43. Patchev V.K., Almeida O.F.X. Gonadal steroids exert facilitating and buffering effects on glucocorticoid-mediated transcriptional regulation of corticotropin-releasing hormone and corticosteroid receptor genes in rat brain. J. Neurosci. 21:1996;7077-7084.
44. Patchev V.K., Hayashi S., Orikasa C., Almeida O.F. Implications of estrogen-dependent brain organization for gender differences in hypothalamic-pituitary-adrenal regulation. FASEB J. 9:1995;419-423.
45. Patisaul H.B., Whitten P.L., Young L.J. Regulation of estrogen receptor beta mRNA in the brain: opposite effects of 17beta-estradiol and the phytoestrogen, coumestrol. Brain Res. Mol. Brain Res. 67:1999;165-171.
46. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1998;Academic Press, Tokyo.
47. Rabbani O., Panickar K.S., Rajakumar G., King M.A., Bodor N., Meyer E.M., Simpkins J.W. 17 Beta-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum. Exp. Neurol. 146:1997;179-186.
48. Reul J.M., Stec I., Soder M., Holsboer F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology. 1:1993;312-320.
49. Seckl J.R., Fink G. Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo. Neuroendocrinology. 55:1992;621-626.
50. Seeman M.V. Psychopathology in women and men: focus on female hormones. Am. J. Psychiatry. 154:1997;1641-1647.
51. Shughrue P.J., Lane M.V., Merchenthaler I. Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J. Comp. Neurol. 388:1997;507-525.
52. Shughrue P.J., Merchenthaler I. Distribution of estrogen receptor beta immunoreactivity in the rat central nervous system. J. Comp. Neurol. 436:2001;64-81.
53. Shughrue P.J., Scrimo P.J., Merchenthaler I. Estrogen binding and estrogen receptor characterization (ERalpha and ERbeta) in the cholinergic neurons of the rat basal forebrain. Neuroscience. 96:2000;41-49.
54. Siiteri P.K., Murai J.T., Hammond G.L., Nisker J.A., Raymoure W.J., Kuhn R.W. The serum transport of steroid hormones. Recent Prog. Horm. Res. 38:1982;457-510.
55. Simerly R.B., Young B.J. Regulation of estrogen receptor messenger ribonucleic acid in rat hypothalamus by sex steroid hormones. Mol. Endocrinol. 5:1991;424-432.
56. Simerly R.B., Chang C., Muramatsu M., Swanson L.W. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J. Comp. Neurol. 294:1990;76-95.
57. Smith C.L., Hammond G.L. Hormonal regulation of corticosteroid-binding globulin biosynthesis in the male rat. Endocrinology. 130:1992;2245-2251.
58. Stutzmann G.E., McEwen B.S., LeDoux J.E. Serotonin modulation of sensory inputs to the lateral amygdala: dependency on corticosterone. J. Neurosci. 22:1998;9529-9538.
59. Turner B.B. Sex differences in the binding of type I and type II corticoid receptors in rat hippocampus. Brain Res. 581:1992;229-236.
60. Turner B.B. Influence of gonadal steroids on brain corticosteroid receptors: a minireview. Neurochem. Res. 22:1997;1375-1385.
61. Turner B.B., Weaver D.A. Sexual dimorphism of glucocorticoid binding in rat brain. Brain Res. 343:1985;16-23.
62. van Eekelen J.A., Rots N.Y., Sutanto W., Oitzl M.S., de Kloet E.R. Brain corticosteroid receptor gene expression and neuroendocrine dynamics during aging. J. Steroid Biochem. Mol. Biol. 40:1991;679-683.
63. Vianu V., Meaney M. Variations in the hypothalamic-pituitary-adrenal response to stress during estrous cycle in the rat. Endocrinology. 129:1991;2503-2511.
64. Weiland N.G., Orikasa C., Hayashi S., McEwen B.S. Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female rats. J. Comp. Neurol. 388:1997;603-612.
65. Wong M.L., Licinio J. Research and treatment approaches to depression. Nat. Rev. Neurosci. 5:2001;343-351.
66. Yokosuka M., Okamura H., Hayashi S. Postnatal development and sex difference in neurons containing estrogen receptor-alpha immunoreactivity in the preoptic brain, the diencephalon, and the amygdala in the rat. J. Comp. Neurol. 389:1997;81-93.
67. Yuri K., Kawata M. The effect of estrogen on the estrogen receptor-immunoreactive cells in the rat medial preoptic nucleus. Brain Res. 548:1991;50-54.
68. Zhang J.Q., Cai W.Q., Zhou de S., Su B.Y. Distribution and differences of estrogen receptor beta immunoreactivity in the brain of adult male and female rats. Brain Res. 935:2002;73-80.