Estrogen binding and estrogen receptor characterization (ERα and ERβ) in the cholinergic neurons of the rat basal forebrain

Neuroscience

Volumn 96, Issue 1, 2000, Pages 41-49

  Shughrue, P J ^a   Scrimo, P J ^a   Merchenthaler, I ^a  

^a WYETH AYERST RESEARCH   (United States)

Author keywords

Alzheimer's disease; Cognition; Gonadal hormones; Menopause; Neurodegeneration; Steroid

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; CHOLINERGIC NERVE CELL; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; ESTROGEN ACTIVITY; ESTROGEN BINDING; FEMALE; FOREBRAIN; IMMUNOCYTOCHEMISTRY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CHOLINE O-ACETYLTRANSFERASE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; FEMALE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NEURONS; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 0033967348     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(99)00520-5     Document Type: Article

References (41)

1. Bartus R.T., Dean R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217:1982;408-417.
2. Beninger R.J., Wirsching B.A., Jhamandas K., Boegman R.J. Animal studies of brain acetylcholine and memory. Archs Gerontol. Geriatr. 1:1989;71-89.
3. Birge S.J. Is there a role for estrogen replacement therapy in the prevention and treatment of dementia? J. Am. Geriatr. Soc. 44:1996;865-870.
4. Birge S.J. The role of estrogen in the treatment of Alzheimer's disease? Neurology. 48:1997;S36-S41.
5. Blaustein J. D. and Olster D. H. (1989) Gonadal steroid hormone receptors and social behaviors. In Advances in Comparative Environmental Physiology (ed. Balthazart J.), Vol 3, pp. 31-104. Springer-Verlag, Berlin.
6. Buckwalter J.G., Sobel E., Dunn M.E., Diz M.M., Henderson V.W. Gender differences on a brief measure of cognitive functioning in Alzheimer's disease. Archs Neurol. 50:1993;757-760.
7. Coyle J.T., Price D.L., DeLong M.R. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science. 219:1983;1184-1190.
8. Desmond N.L., Levy W.B. Ovarian steroidal control of connectivity in the female hippocampus: an overview of recent experimental findings and speculations on its functional consequences. Hippocampus. 7:1997;239-245.
9. Fader A.J., Hendricson A.W., Dohanich G.P. Estrogen improves preformance of reinforced T-maze alternation and prevents the amnestic effects of scopolamine administered systemically or intrahippocampally. Neurobiol. Learn. Mem. 69:1998;225-240.
10. NGFR and ChAT expression in the medial septum and diagonal band of Broca. Expl Neurol. 116:1992;23-39.
11. Gibbs R. B. (1994) Estrogen and nerve growth factor-related systems in brain: effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging. In Hormonal Restructuring of the Adult Brain: Basic and Clinical Perspectives (eds Luine V. N. and Harding C. F.), pp. 165-199, New York Academy of Sciences, New York.
12. Gibbs R.B. Expression of estrogen receptor-like immunoreactivity by different subgroups of basal forebrain cholinergic neurons in gonadectomized male and female rats. Brain Res. 720:1996;61-68.
13. Gibbs R.B. Fluctuations in relative levels of choline acetyltransferase mRNA in different regions of the rat basal forebrain across the estrous cycle: effects of estrogen and progesterone. J. Neurosci. 16:1996;1049-1055.
14. Hampson E. Estrogen-related variations in human spatial and articulatory motor skills. Psychoneuroendocrinology. 15:1990;97-111.
15. Henderson V.W., Paganini-Hill A., Emanuel C.K., Dunn M.E., Buckwalter J.G. Estrogen replacement therapy in older women: comparisons between Alzheimer's disease cases and nondemented control subjects. Archs Neurol. 51:1994;896-900.
16. Herbison A.E. Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons. Endocr. Rev. 19:1998;302-330.
17. Hughes A., Larson S.M., Hanson R.N., DeSombre E.R. Uptake and interconversion of the Z and E isomers of 17α-iodovinyl-11β methoxyestradiol in the immature female rat. Steroids. 62:1997;244-252.
18. Kuiper G.G.J.M., Enmark E., Pelto-Huikko M., Nilsson S., Gustafsson J.-Å. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. natn. Acad. Sci. U.S.A. 93:1996;5925-5930.
19. Laflamme N., Nappi R.E., Drolet G., Labrie C., Rivest S. Expression and neuropeptidergic characterization of estrogen receptors (ERα and ERβ) throughout the rat brain: anatomical evidence of distinct roles of each subtype. J. Neurobiol. 36:1998;357-378.
20. Luine V.N. Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats. Expl Neurol. 89:1985;484-490.
21. McEwen B.S., Alves S.E., Bulloch K., Weiland N.G. Ovarian steroids and the brain: implications for cognition and aging. Neurology. 48:1997;S8-S15.
22. McMillan P.J., Singer C.A., Dorsa D.M. The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague-Dawley rat. J. Neurosci. 16:1996;1860-1865.
23. Paganini-Hill A., Henderson V.W. Estrogen deficiency and risk of Alzheimer's disease in women. Am. J. Epidemiol. 140:1994;256-261.
24. Paxinos G. and Watson C. (1982) The Rat Brain in Stereotaxic Coordinates. Academic, New York.
25. Rabbani O., Panickar K.S., Rajakumar G., King M.A., Bodor N., Meyer E.M., Simpkins J.W. 17β-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum. Expl Neurol. 146:1997;179-186.
26. Sherwin B.B. Estrogenic effects on memory in women. Ann. N.Y. Acad. Sci. 743:1994;213-231.
27. Sherwin B.B., Tulandi T. "Add back" estrogen reverses cognitive deficits induced by a gonadotropin-releasing hormone agonist in women with leiomyomata uteri. J. clin. Endocrinol. Metab. 81:1996;2545-2549.
28. Shughrue P.J., Bushnell C.D., Dorsa D.M. Estrogen receptor messenger ribonucleic acid in female rat brain during the estrous cycle: a comparison with ovariectomized females and intact males. Endocrinology. 131:1992;381-388.
29. Shughrue P.J., Komm B., Merchenthaler I. The distribution of estrogen receptor-β mRNA in the rat hypothalamus. Steroids. 61:1996;678-681.
30. Shughrue P.J., Lane M.V., Merchenthaler I. The distribution of neurokinin B receptor mRNA (NK-3) in the female rat central nervous system and pituitary: an in situ hybridization study. J. comp. Neurol. 372:1996;395-414.
31. Shughrue P.J., Lane M.V., Merchenthaler I. The comparative distribution of estrogen receptor-α and β mRNA in the rat central nervous system. J. comp. Neurol. 388:1997;507-525.
32. Shughrue P.J., Scrimo P.J., Merchenthaler I. Evidence for the colocalization of estrogen receptor-β mRNA and estrogen receptor-α immunoreactivity in neurons of the rat forebrain. Endocrinology. 139:1998;5267-5270.
33. Shughrue P.J., Lane M.V., Merchenthaler I. Biologically active estrogen receptor-β: evidence from in vivo autoradiographic studies with estrogen receptor α-knockout mice. Endocrinology. 140:1999;2613-2620.
34. Shughrue P.J., Merchenthaler I. Estrogen is more than just a "sex hormone": novel sites for estrogen action in the hippocampus and cerebral cortex. Front Neuroendocr. 21:2000;1-7.
35. Simerly R.B., Chang C., Muramatsu M., Swanson L.W. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J. comp. Neurol. 294:1990;76-95.
36. Simerly R.B., Carr A.M., Zee M.C., Lorand D. Ovarian steroid regulation of estrogen and progesterone receptor messenger ribonucleic acid in the anteroventral periventricular nucleus of the rat. J. Neuroendocr. 8:1996;45-56.
37. Singh M., Meyer E.M., Millard W.J., Simpkins J.W. Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats. Brain Res. 644:1994;305-312.
38. Tang M.X., Jacobs D., Stern Y., Marder K., Schofield P., Gurland B., Andrews H., Mayeux R. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet. 348:1996;429-432.
39. Toran-Allerand C.D., Miranda R.C., Bentham W.D., Sohrabji F., Brown T.J., Hochberg R.B., MacLusky N.J. Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proc. natn. Acad. Sci. U.S.A. 89:1992;4668-4672.
40. Whitehouse P.J., Price D.L., Struble R.G., Clark A.W., Coyle J.T., DeLong M.R. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science. 215:1982;1237-1239.
41. Zhou Y., Shughrue P.J., Dorsa D.M. Estrogen receptor protein is differentially regulated in the preoptic area of the brain and in the uterus during the rat estrous cycle. Neuroendocrinology. 61:1995;276-283.