T-cell-dependent antitumor effects produced by CD40 ligand expressed on mouse lung carcinoma cells are linked with the maturation of dendritic cells and secretion of a variety of cytokines

Cancer Gene Therapy

Volumn 10, Issue 6, 2003, Pages 451-456

  Tada, Yuji ^a,b   O Wang, Jiyang ^a   Yu, Ling ^a   Shimozato, Osamu ^a   Wang, Yan Qing ^a   Takiguchi, Yuichi ^b   Tatsumi, Koichiro ^b   Kuriyama, Takayuki ^b   Takenaga, Keizo ^a   Sakiyama, Shigeru ^a   Tagawa, Masatoshi ^a  

^a CHIBA CANCER CENTER   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

CD40 ligand; Dendritic cells; IL 12; IL 23; Lung cancer

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; CD86 ANTIGEN; CYTOKINE; PROTEIN SUBUNIT;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CELL; CANCER INHIBITION; CARCINOMA CELL; CD40L GENE; CELL MATURATION; CELL PROLIFERATION; CELLULAR IMMUNITY; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; GAMMA INTERFERON GENE; GENE; GENE EXPRESSION; IMMUNOCOMPETENCE; INTERLEUKIN 12P35 GENE; INTERLEUKIN 18 GENE; INTERLEUKIN 23P19 GENE; LUNG CARCINOMA; MIG GENE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR GROWTH;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD86; CARCINOMA, LEWIS LUNG; CD40 LIGAND; CELL DIVISION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-23; INTERLEUKIN-23 SUBUNIT P19; INTERLEUKINS; LUNG NEOPLASMS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TIME FACTORS; TRANSFECTION; UP-REGULATION;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 0037601895     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700584     Document Type: Article

References (24)

1. Cella M, Scheidegger D, Palmer-Lehmann K, et al. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med. 1996;184:747-752.
2. Peng X, Kasran A, Warmerdam PA, et al. Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-γ production. Eur J Immunol. 1996;26:1621-1627.
3. Yang Y, Wilson JM. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science. 1996;273:1862-1864.
4. Grewal IS, Flavell RA. The role of CD40 ligand in costimulation and T-cell activation. Immunol Rev. 1996;153:85-106.
5. Mackey MF, Gunn JR, Ting PP, et al. Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154. Cancer Res. 1997;57:2569-2574.
6. Kikuchi T, Crystal RG. Anti-tumor immunity induced by in vivo adenovirus vector-mediated expression of CD40 ligand in tumor cells. Hum Gene Ther. 1999;10:1375-1387.
7. Noguchi M, Imaizumi K, Kawabe T, et al. Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-γ gene into lung cancer. Cancer Gene Ther. 2001;8:421-429.
8. Wierda WG, Cantwell MJ, Woods SJ, et al. CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia. Blood. 2000;96:2917-2924.
9. Kikuchi T, Moore MAS, Crystal RG. Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors. Blood. 2000;96:91-99.
10. + cytotoxic T-cell activation and antitumor immunity. Cancer Gene Ther. 2002;9:202-208.
11. Korst RJ, Mahtabifard A, Yamada R, Crystal RG. Effect of adenovirus gene transfer vectors on the immunologic functions of mouse dendritic cells. Mol Ther. 2002;5:307-315.
12. Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13:715-725.
13. Takasu M, Tada Y, Wang JO, Tagawa M, Takenaga K. Resistance to apoptosis induced by microenvironmental stresses is correlated with metastatic potential in Lewis lung carcinoma. Clin Exp Metastasis. 1999;17:409-416.
14. Tada Y, O-Wang J, Takiguchi Y, et al. A novel role for Fas ligand in facilitating antigen acquisition by dendritic cells. J Immunol. 2002;169:2241-2245.
15. Rescigno M, Piguet V, Valzasina B, et al. Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1β, and the production of interferon γ in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory responses. J Exp Med. 2000;192:1661-1668.
16. Gardella S, Andrei C, Costigliolo S, et al. Interleukin-18 synthesis and secretion by dendritic cells are modulated by interaction with antigen-specific T cells. J Leukoc Biol. 1999;66:237-241.
17. Stober D, Schirmbeck R, Reimann J. IL-12/IL-18-dependent IFN-γ release by murine dendritic cells. J Immunol. 2001;167:957-965.
18. Morelli AE, Zahorchak AF, Larregina AT, et al. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood. 2001;98:1512-1523.
19. + effector T cells. J Leukoc Biol. 2002;71:669-676.
20. Wong P, Severns CW, Guyer NB, Wright TM. A unique palindromic element mediates gamma interferon induction of mig gene expression. Mol Cell Biol. 1994;14:914-922.
21. Kuniyoshi JS, Kuniyoshi CJ, Lim AM, et al. Dendritic cell secretion of IL-15 is induced by recombinant huCD40LT and augments the stimulation of antigen-specific cytolytic T cells. Cell Immunol. 1999;193:48-58.
22. Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408:57-63.
23. Kasaian MT, Whitters MJ, Carter LL, et al. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity. 2002;16:559-569.
24. Batrla R, Linnebacher M, Rudy W, et al. CD40-expressing carcinoma cells induce down-regulation of CD40 ligand (CD154) and impair T-cell functions. Cancer Res. 2002;62:2052-2057.