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Volumn 85, Issue 5, 2003, Pages 1200-1207

Pentylenetetrazole decreases metabolic glutamate turnover in rat brain

Author keywords

aminobutyric acid; Aspartate; Cerebellum; Epilepsy; Glutamate; Pentylenetetrazole

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; ACETIC ACID; ASPARTIC ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; PENTETRAZOLE; TAURINE;

EID: 0037565385     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01781.x     Document Type: Article
Times cited : (34)

References (55)
  • 1
    • 0025181507 scopus 로고
    • Cerebral metabolism of acetate and glucose studied by 13C-n.m.r. spectroscopy. A technique for investigating metabolic compartmentation in the brain
    • Badar-Goffer R. S., Bachelard H. S. and Morris P. G. (1990) Cerebral metabolism of acetate and glucose studied by 13C-n.m.r. spectroscopy. A technique for investigating metabolic compartmentation in the brain. Biochem. J. 266, 133-139.
    • (1990) Biochem. J. , vol.266 , pp. 133-139
    • Badar-Goffer, R.S.1    Bachelard, H.S.2    Morris, P.G.3
  • 2
    • 0000984835 scopus 로고
    • Metabolic compartmentation of glutamate in the CNS
    • Lajtha A., ed. Plenum Press, New York
    • Berl S. and Clarke D. D. (1969) Metabolic compartmentation of glutamate in the CNS, in Handbook of Neurochemistry (Lajtha A., ed.), pp. 447-472. Plenum Press, New York.
    • (1969) Handbook of Neurochemistry , pp. 447-472
    • Berl, S.1    Clarke, D.D.2
  • 3
    • 0008213241 scopus 로고
    • Glutamate, GABA and epilepsy
    • Bradford H. F. (1989) Glutamate, GABA and epilepsy. Epilepsia 30, 17-25.
    • (1989) Epilepsia , vol.30 , pp. 17-25
    • Bradford, H.F.1
  • 4
    • 0030969467 scopus 로고    scopus 로고
    • Role of adenosine in the ethanol-induced potentiation of the effects of general anesthetics in rats
    • Campisi P., Carmichael F. J., Crawford M., Orrego H. and Khanna J. M. (1997) Role of adenosine in the ethanol-induced potentiation of the effects of general anesthetics in rats. Eur. J. Pharmacol. 325, 165-172.
    • (1997) Eur. J. Pharmacol. , vol.325 , pp. 165-172
    • Campisi, P.1    Carmichael, F.J.2    Crawford, M.3    Orrego, H.4    Khanna, J.M.5
  • 6
    • 0028966538 scopus 로고
    • Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase
    • Cesar M. and Hamprecht B. (1995) Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase. J. Neurochem. 64, 2312-2318.
    • (1995) J. Neurochem. , vol.64 , pp. 2312-2318
    • Cesar, M.1    Hamprecht, B.2
  • 8
    • 0020445584 scopus 로고
    • The effects of convulsant and anticonvulsant drugs on the release of radiolabeled GABA, glutamate, noradrenaline, serotonine and acetylcholine from rat cortical slices
    • De Boer T., Stoof J. C. and van Duijn H. (1982) The effects of convulsant and anticonvulsant drugs on the release of radiolabeled GABA, glutamate, noradrenaline, serotonine and acetylcholine from rat cortical slices. Brain Res. 253, 153-160.
    • (1982) Brain Res. , vol.253 , pp. 153-160
    • De Boer, T.1    Stoof, J.C.2    Van Duijn, H.3
  • 9
    • 0024595518 scopus 로고
    • Effects of antiepileptic drugs on GABA responses and on reduction of GABA responses by PTZ and DMCM on mouse neurons in cell culture
    • De Deyn P. P. and Macdonald R. L. (1989) Effects of antiepileptic drugs on GABA responses and on reduction of GABA responses by PTZ and DMCM on mouse neurons in cell culture. Epilepsia 30, 17-25.
    • (1989) Epilepsia , vol.30 , pp. 17-25
    • De Deyn, P.P.1    Macdonald, R.L.2
  • 10
    • 0017137011 scopus 로고
    • Release of amino acids from the maturing cobalt-induced epileptic focus
    • Dodd P. R. and Bradford H. F. (1976) Release of amino acids from the maturing cobalt-induced epileptic focus. Brain Res. 111, 377-388.
    • (1976) Brain Res. , vol.111 , pp. 377-388
    • Dodd, P.R.1    Bradford, H.F.2
  • 12
    • 0035089452 scopus 로고    scopus 로고
    • Altered activities of rat brain metabolic enzymes in electroconvulsive shock-induced seizures
    • Erakovic V., Zupan G., Varljen J., Laginja J. and Simonic A. (2001a) Altered activities of rat brain metabolic enzymes in electroconvulsive shock-induced seizures. Epilepsia 42, 181-189.
    • (2001) Epilepsia , vol.42 , pp. 181-189
    • Erakovic, V.1    Zupan, G.2    Varljen, J.3    Laginja, J.4    Simonic, A.5
  • 13
    • 0035151148 scopus 로고    scopus 로고
    • Altered activities of rat brain metabolic enzymes caused by pentylenetetrazol kindling and pentylenetetrazol-induced seizures
    • Erakovic V., Zupan G., Varljen J., Laginja J. and Simonic A. (2001b) Altered activities of rat brain metabolic enzymes caused by pentylenetetrazol kindling and pentylenetetrazol-induced seizures. Epilepsy Res. 43, 165-173.
    • (2001) Epilepsy Res. , vol.43 , pp. 165-173
    • Erakovic, V.1    Zupan, G.2    Varljen, J.3    Laginja, J.4    Simonic, A.5
  • 14
    • 0024449997 scopus 로고
    • Animal models of the epilepsies
    • Fisher R. S. (1989) Animal models of the epilepsies. Brain Res. 14, 245-278.
    • (1989) Brain Res. , vol.14 , pp. 245-278
    • Fisher, R.S.1
  • 15
    • 0021330769 scopus 로고
    • Glutamate: A neurotransmitter in mammalian brain
    • Fonnum F. (1984) Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 42, 1-11.
    • (1984) J. Neurochem. , vol.42 , pp. 1-11
    • Fonnum, F.1
  • 16
    • 0021339969 scopus 로고
    • Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and γ-aminobuttyric acid
    • Geddes J. W. and Wood J. D. (1984) Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and γ-aminobuttyric acid. J. Neurochem. 42, 16-24.
    • (1984) J. Neurochem. , vol.42 , pp. 16-24
    • Geddes, J.W.1    Wood, J.D.2
  • 17
    • 0032529722 scopus 로고    scopus 로고
    • Synaptic vesicular localization and exocytosis of 1-aspartate in excitatory nerve terminals: A quantitative immunogold analysis in rat hippocampus
    • Gundersen V., Chaudhry F. A., Bjaalie J. G., Fonnum F., Ottersen O. P. and Storm-Mathisen J. (1998) Synaptic vesicular localization and exocytosis of 1-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus. J. Neurosci. 18, 6059-6070.
    • (1998) J. Neurosci. , vol.18 , pp. 6059-6070
    • Gundersen, V.1    Chaudhry, F.A.2    Bjaalie, J.G.3    Fonnum, F.4    Ottersen, O.P.5    Storm-Mathisen, J.6
  • 18
    • 0035192655 scopus 로고    scopus 로고
    • Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: A quantitative immunogold study
    • Gundersen V., Fonnum F., Ottersen O. P. and Storm-Mathisen J. (2001) Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study. J. Cereb. Blood Flow Metab. 21, 41-51.
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 41-51
    • Gundersen, V.1    Fonnum, F.2    Ottersen, O.P.3    Storm-Mathisen, J.4
  • 21
    • 0035189037 scopus 로고    scopus 로고
    • In vivo effects of adenosine A (2) receptor agonist and antagonist on neuronal and astrocytic intermediary metabolism studied with ex vivo (13)C MR spectroscopy
    • Hammer J., Qu H., Haberg A. and Sonnewald U. (2001) In vivo effects of adenosine A (2) receptor agonist and antagonist on neuronal and astrocytic intermediary metabolism studied with ex vivo (13)C MR spectroscopy. J. Neurochem. 79, 885-892.
    • (2001) J. Neurochem. , vol.79 , pp. 885-892
    • Hammer, J.1    Qu, H.2    Haberg, A.3    Sonnewald, U.4
  • 22
    • 0026603607 scopus 로고
    • Selective inhibition of glial cell metabolism in vivo by fluorocitrate
    • Hassel B., Paulsen R. E., Johnsen A. and Fonnum F. (1992) Selective inhibition of glial cell metabolism in vivo by fluorocitrate. Brain Res. 576, 120-124.
    • (1992) Brain Res. , vol.576 , pp. 120-124
    • Hassel, B.1    Paulsen, R.E.2    Johnsen, A.3    Fonnum, F.4
  • 24
    • 0030612955 scopus 로고    scopus 로고
    • Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate
    • Hassel B., Bachelard H., Fonnum F. and Sonnewald U. (1997) Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate. J. Cereb. Blood Flow Metab. 17, 1230-1238.
    • (1997) J. Cereb. Blood Flow Metab. , vol.17 , pp. 1230-1238
    • Hassel, B.1    Bachelard, H.2    Fonnum, F.3    Sonnewald, U.4
  • 25
    • 0002591234 scopus 로고
    • Neuronal-astrocytic interactions in metabolism of transmitter amino acids of the glutamate family
    • Schousboe A., Diemer N. H., Kofod H., eds. Munksgaard, Copenhagen
    • Hertz L., Peng L., Westergaard N., Yudkoff M. and Schousboe A. (1992) Neuronal-astrocytic interactions in metabolism of transmitter amino acids of the glutamate family, in Drug Research Related to Neuroactive Amino Acids (Schousboe A., Diemer N. H., Kofod H., eds), pp. 30-48. Munksgaard, Copenhagen.
    • (1992) Drug Research Related to Neuroactive Amino Acids , pp. 30-48
    • Hertz, L.1    Peng, L.2    Westergaard, N.3    Yudkoff, M.4    Schousboe, A.5
  • 26
    • 0028997385 scopus 로고
    • Models of primary generalized epilepsy
    • Hosford D. A. (1995) Models of primary generalized epilepsy. Curr. Opin. Neurol. 8, 121-125.
    • (1995) Curr. Opin. Neurol. , vol.8 , pp. 121-125
    • Hosford, D.A.1
  • 27
    • 0023757524 scopus 로고
    • Pentylenetetrazole inhibits glutamate dehydrogenase and aspartate aminotransferase, and stimulates GABA aminotransferase in homogenates from rat cerebral cortex
    • Lacoste L., Bartolucci S. and Lapointe J. (1988) Pentylenetetrazole inhibits glutamate dehydrogenase and aspartate aminotransferase, and stimulates GABA aminotransferase in homogenates from rat cerebral cortex. Can. J. Physiol. Pharmacol. 66, 1135-1138.
    • (1988) Can. J. Physiol. Pharmacol. , vol.66 , pp. 1135-1138
    • Lacoste, L.1    Bartolucci, S.2    Lapointe, J.3
  • 28
    • 0034678092 scopus 로고    scopus 로고
    • The effect of pentylenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortex of rats
    • Li Z., Yamamoto Y., Morimoto T., Ono J., Okadam S. and Yamatodani A. (2000) The effect of pentylenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortex of rats. Neurosci. Lett. 282, 117-119.
    • (2000) Neurosci. Lett. , vol.282 , pp. 117-119
    • Li, Z.1    Yamamoto, Y.2    Morimoto, T.3    Ono, J.4    Okadam, S.5    Yamatodani, A.6
  • 29
    • 0017602720 scopus 로고
    • Phenobarbital enhances GABA-mediated postsynaptic inhibition in cultured mammalian neurons
    • Macdonald R. L. and Barker J. L. (1977) Phenobarbital enhances GABA-mediated postsynaptic inhibition in cultured mammalian neurons. Trans. Am. Neurol. Assoc. 102, 139-140.
    • (1977) Trans. Am. Neurol. Assoc. , vol.102 , pp. 139-140
    • Macdonald, R.L.1    Barker, J.L.2
  • 30
    • 0018140477 scopus 로고
    • Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons
    • Macdonald R. L. and Barker J. L. (1978) Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons. Science 200, 775-777.
    • (1978) Science , vol.200 , pp. 775-777
    • Macdonald, R.L.1    Barker, J.L.2
  • 31
    • 0017579832 scopus 로고
    • Glutamine synthetase: Glial localization in brain
    • Martinez-Hernandez A., Bell K. P. and Norenberg M. D. (1977) Glutamine synthetase: glial localization in brain. Science 195, 1356-1358.
    • (1977) Science , vol.195 , pp. 1356-1358
    • Martinez-Hernandez, A.1    Bell, K.P.2    Norenberg, M.D.3
  • 32
    • 0019900917 scopus 로고
    • Pentylenetetrazole induced changes in cerebellar energy metabolism
    • McCandless D. W. and Schwartzenburg F. C. Jr (1982) Pentylenetetrazole induced changes in cerebellar energy metabolism. Neurochem. Res. 7, 811-819.
    • (1982) Neurochem. Res. , vol.7 , pp. 811-819
    • McCandless, D.W.1    Schwartzenburg F.C., Jr.2
  • 33
    • 0024410491 scopus 로고
    • GABAergic mechanisms in the pathogenesis and treatment of epilepsy
    • Meldrum B. S. (1989) GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br. J. Clin. Pharmacol. 27, 3S-11S.
    • (1989) Br. J. Clin. Pharmacol. , vol.27
    • Meldrum, B.S.1
  • 34
    • 0022505025 scopus 로고
    • Acetate and fluoroacetate as possible markers for glial metabolism in vivo
    • Muir D., Berl S. and Clarke D. D. (1986) Acetate and fluoroacetate as possible markers for glial metabolism in vivo. Brain Res. 20, 336-340.
    • (1986) Brain Res. , vol.20 , pp. 336-340
    • Muir, D.1    Berl, S.2    Clarke, D.D.3
  • 35
    • 0025052336 scopus 로고
    • The release and uptake of excitatory amino acids
    • Nicholls D. and Attwell D. (1990) The release and uptake of excitatory amino acids. Trends Pharmacol. Sci. 11, 462-468.
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 462-468
    • Nicholls, D.1    Attwell, D.2
  • 36
    • 0018382256 scopus 로고
    • Fine structural localization of glutamine synthetase in astrocytes of rat brain
    • Norenberg M. D. and Martinez-Hernandez A. (1979) Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res. 161, 303-310.
    • (1979) Brain Res. , vol.161 , pp. 303-310
    • Norenberg, M.D.1    Martinez-Hernandez, A.2
  • 37
    • 0021716227 scopus 로고
    • Glutamate-and GABA-containmg containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique
    • Ottersen O. P. and Storm-Mathisen J. (1984) Glutamate-and GABA-containmg containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique. J. Comp. Neurol. 229, 374-392.
    • (1984) J. Comp. Neurol. , vol.229 , pp. 374-392
    • Ottersen, O.P.1    Storm-Mathisen, J.2
  • 38
    • 0022369860 scopus 로고
    • Different neuronal localization of aspartate-like and glutamate-like immunoreactivities in the hippocampus of rat, guinea-pig and Senegalese baboon (Papio papio), with a note on the distribution of gamma-aminobutyrate
    • Ottersen O. P. and Storm-Mathisen J. (1985) Different neuronal localization of aspartate-like and glutamate-like immunoreactivities in the hippocampus of rat, guinea-pig and Senegalese baboon (Papio papio), with a note on the distribution of gamma-aminobutyrate. Neuroscience 16, 589-606.
    • (1985) Neuroscience , vol.16 , pp. 589-606
    • Ottersen, O.P.1    Storm-Mathisen, J.2
  • 39
    • 0024411518 scopus 로고
    • Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for release of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons
    • Palaiologos G., Hertz L. and Schousboe A. (1989) Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for release of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons. Neurochem. Res. 14, 359-366.
    • (1989) Neurochem. Res. , vol.14 , pp. 359-366
    • Palaiologos, G.1    Hertz, L.2    Schousboe, A.3
  • 40
    • 0016159619 scopus 로고
    • Regulation of pyruvate carboxylase in rat brain mitochondria: Effect of fluoropyruvate
    • Patel M. S. (1974) Regulation of pyruvate carboxylase in rat brain mitochondria: effect of fluoropyruvate. Brain Res. 76, 174-177.
    • (1974) Brain Res. , vol.76 , pp. 174-177
    • Patel, M.S.1
  • 41
    • 0027431068 scopus 로고
    • Differential regulation of N-methyl-D-aspartate receptor subunit messenger RNAs in kindling-induced epileptogenesis
    • Pratt G. D., Kokaia M., Bengzon J., Kokaia Z., Fritschy J. M., Mohler H. and Lindvall O. (1993) Differential regulation of N-methyl-D-aspartate receptor subunit messenger RNAs in kindling-induced epileptogenesis. Neuroscience 57, 307-318.
    • (1993) Neuroscience , vol.57 , pp. 307-318
    • Pratt, G.D.1    Kokaia, M.2    Bengzon, J.3    Kokaia, Z.4    Fritschy, J.M.5    Mohler, H.6    Lindvall, O.7
  • 44
    • 0037210203 scopus 로고    scopus 로고
    • Glial neuronal interactions following kainate injection in rats
    • Qu H., Eloqayli H., Müller B., Aasly J. and Sonnewald U. (2003) Glial neuronal interactions following kainate injection in rats. Neurochem. Int. 42, 101-106.
    • (2003) Neurochem. Int. , vol.42 , pp. 101-106
    • Qu, H.1    Eloqayli, H.2    Müller, B.3    Aasly, J.4    Sonnewald, U.5
  • 45
    • 0021685460 scopus 로고
    • GABA-related phenomena, models of nervous system function, and seizures
    • Roberts E. (1984) GABA-related phenomena, models of nervous system function, and seizures. Ann. Neurol. 16, S77-S89.
    • (1984) Ann. Neurol. , vol.16
    • Roberts, E.1
  • 48
    • 0021122793 scopus 로고
    • Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in brain
    • Squires R. F., Saederup E., Crawley J. N., Skolnick P. and Paul S. M. (1984) Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in brain. Life Sci. 35, 1439-1444.
    • (1984) Life Sci. , vol.35 , pp. 1439-1444
    • Squires, R.F.1    Saederup, E.2    Crawley, J.N.3    Skolnick, P.4    Paul, S.M.5
  • 49
    • 0025958468 scopus 로고
    • Glutamine synthetase in oligodendrocytes and astrocytes: New biochemical and immunocytochemical evidence
    • Tansey F. A., Farooq M. and Cammer W. (1991) Glutamine synthetase in oligodendrocytes and astrocytes: new biochemical and immunocytochemical evidence. J. Neurochem. 56, 266-272.
    • (1991) J. Neurochem. , vol.56 , pp. 266-272
    • Tansey, F.A.1    Farooq, M.2    Cammer, W.3
  • 51
    • 0034865645 scopus 로고    scopus 로고
    • GABAergic mechanisms in epilepsy
    • Treiman D. M. (2001) GABAergic mechanisms in epilepsy. Epilepsia 42, 8-12.
    • (2001) Epilepsia , vol.42 , pp. 8-12
    • Treiman, D.M.1
  • 52
    • 0015071185 scopus 로고
    • A stimulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain
    • Van den Berg C. J. and Garfinkel D. (1971) A stimulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain. Biochem. J. 123, 211-218.
    • (1971) Biochem. J. , vol.123 , pp. 211-218
    • Van den Berg, C.J.1    Garfinkel, D.2
  • 53
    • 0032992977 scopus 로고    scopus 로고
    • Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels, GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density
    • Walsh L. A., Li M., Zhao T. J., Chiu T. H. and Rosenberg H. C. (1999) Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels, GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J. Pharmacol. Exp. Ther. 289, 1626-1633.
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 1626-1633
    • Walsh, L.A.1    Li, M.2    Zhao, T.J.3    Chiu, T.H.4    Rosenberg, H.C.5
  • 54
    • 0032527892 scopus 로고    scopus 로고
    • Preferential utilization of acetate by astrocytes is attributable to transport
    • Waniewski R. A. and Martin D. L. (1998) Preferential utilization of acetate by astrocytes is attributable to transport. J. Neurosci. 18, 5225-5233.
    • (1998) J. Neurosci. , vol.18 , pp. 5225-5233
    • Waniewski, R.A.1    Martin, D.L.2
  • 55
    • 0021037707 scopus 로고
    • Pyruvate carboxylase activity in primary cultures of astrocytes and neurons
    • Yu A. C. H., Drejer J., Hertz L. and Schousboe A. (1983) Pyruvate carboxylase activity in primary cultures of astrocytes and neurons. J. Neurochem. 41, 1484-1487.
    • (1983) J. Neurochem. , vol.41 , pp. 1484-1487
    • Yu, A.C.H.1    Drejer, J.2    Hertz, L.3    Schousboe, A.4


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